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T‐cell immunoglobulin and mucin domain 3 (TIM‐3) is an Ig‐superfamily member expressed on IFN‐γ‐secreting Th1 and Tc1 cells and was identified as a negative regulator of immune tolerance. TIM‐3 is expressed by a subset of activated CD4+ T cells, and anti‐CD3/anti‐CD28 stimulation increases both the level of expression and the number of TIM‐3+ T cells. In mice, TIM‐3 is constitutively expressed on...