Search results for: Jan Belohlavek

Items from 1 to 20 out of 31 results

article

Initiation of sacubitril/valsartan shortly after hospitalisation for acutely decompensated heart failure in patients with newly diagnosed (de novo) heart failure: a subgroup analysis of the TRANSITION study

Michele Senni, Rolf Wachter, Klaus K. Witte, Ewa Straburzynska‐Migaj, more

European Journal of Heart Failure > 22 > 2 > 303 - 312

Aims Sacubitril/valsartan has shown efficacy and tolerability in patients with heart failure (HF) and reduced ejection fraction (HFrEF) in the ambulatory setting (PARADIGM‐HF), and following stabilisation of acutely decompensated HF (ADHF) (PIONEER‐HF and TRANSITION). However, data are lacking for the initiation of sacubitril/valsartan in newly diagnosed (de novo) HFrEF. Here, we assess the tolerability...

article

Initiation of sacubitril/valsartan in haemodynamically stabilised heart failure patients in hospital or early after discharge: primary results of the randomised TRANSITION study

Rolf Wachter, Michele Senni, Jan Belohlavek, Ewa Straburzynska‐Migaj, more

European Journal of Heart Failure > 21 > 8 > 998 - 1007

Aims To assess tolerability and optimal time point for initiation of sacubitril/valsartan in patients stabilised after acute heart failure (AHF). Methods and results TRANSITION was a randomised, multicentre, open‐label study comparing two treatment initiation modalities of sacubitril/valsartan. Patients aged ≥ 18 years, hospitalised for AHF were stratified according to pre‐admission use of renin–angiotensin–aldosterone...

article

A trial to evaluate the effect of the sodium–glucose co‐transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA‐HF)

John J.V. McMurray, David L. DeMets, Silvio E. Inzucchi, Lars Køber, more

European Journal of Heart Failure > 21 > 5 > 665 - 675

Background Sodium–glucose co‐transporter 2 (SGLT2) inhibitors have been shown to reduce the risk of incident heart failure hospitalization in individuals with type 2 diabetes who have, or are at high risk of, cardiovascular disease. Most patients in these trials did not have heart failure at baseline and the effect of SGLT2 inhibitors on outcomes in individuals with established heart failure (with...

article

Validation of new marker of fluid responsiveness based on Doppler assessment of blood flow velocity in superior vena cava in mechanically ventilated pigs

Tomas Kovarnik, Miroslav Navratil, Jan Belohlavek, Mikulas Mlcek, more

Intensive Care Medicine Experimental > 2018 > 6 > 1 > 1-13

Background We studied a novel approach for the evaluation and management of volemia: minimally invasive monitoring of respiratory blood flow variations in the superior vena cava (SVC). We performed an experiment with 10 crossbred (Landrace × large white) female pigs (Sus scrofa domestica). Methods Hypovolemia was induced by bleeding from a femoral artery, in six stages. This was followed by blood...

article

Position paper for the organization of ECMO programs for cardiac failure in adults

Darryl Abrams, A. Reshad Garan, Akram Abdelbary, Matthew Bacchetta, more

Intensive Care Medicine > 2018 > 44 > 6 > 717-729

Extracorporeal membrane oxygenation (ECMO) has been used increasingly for both respiratory and cardiac failure in adult patients. Indications for ECMO use in cardiac failure include severe refractory cardiogenic shock, refractory ventricular arrhythmia, active cardiopulmonary resuscitation for cardiac arrest, and acute or decompensated right heart failure. Evidence is emerging to guide the use of...

article

Surgical Revascularisation in the Early Phase of ST-Segment Elevation Myocardial Infarction: Haemodynamic Status is More Important Than the Timing of the Operation

Vilem Rohn, Tomas Grus, Jan Belohlavek, Jan Horak

Heart, Lung and Circulation > 2017 > 26 > 12 > 1323-1329

Surgical revascularisation in patients with acute myocardial infarction with ST-Segment Elevation (STEMI) is usually considered as a second choice when direct angioplasty/stent fails. However, improvements in surgical technique and postoperative care may justify coronary artery bypass grafting (CABG) in STEMI.This was a retrospective analysis of prospectively gathered data of 135 patients with acute...

article

Effect of a 6-month pedometer-based walking intervention on functional capacity in patients with chronic heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction: study protocol for two multicenter randomized controlled trials

Tomas Vetrovsky, Michal Siranec, Jiri Parenica, Martin Griva, more

Journal of Translational Medicine > 2017 > 15 > 1 > 1-10

Background Regular physical activity is recommended for patients with chronic heart failure to improve their functional capacity, and walking is a popular, effective, and safe form of physical activity. Pedometers have shown potential to increase the amount of walking across a range of chronic diseases, but it is unknown whether a pedometer-based intervention improves functional capacity and neurohumoral...

article

Psychosocial sequelae following cardiac arrest

Veronika Dostálová, Kamil Sedláček, Jan Bělohlávek, Radovan Turek, more

Cor et Vasa > 2017 > 59 > 3 > e222-e228

Cardiac arrest (CA) leads to cerebral hypoxia resulting in multifactorial brain injury. Cognitive impairment and a higher degree of depressive symptoms are the most frequently described mental health problems after CA. The aim of the present study is to characterize psychosocial sequelae of CA.The study population included 113 subjects. 62 patients after CA were matched to 51 healthy controls according...

article

Cost-effectiveness of hospital treatment and outcomes of acute methanol poisoning during the Czech Republic mass poisoning outbreak

Jan Rulisek, Martin Balik, Ferdinand Polak, Petr Waldauf, more

Journal of Critical Care > 2017 > 39 > C > 190-198

During an outbreak of mass methanol poisoning in the Czech Republic in 2012–2014, we compared the total hospital costs and one-year medical costs in the patients treated with different antidotes (fomepizole versus ethanol) and modalities of hemodialysis (intermittent hemodialysis, IHD, versus continuous renal replacement therapy, CRRT).Cross-sectional study in 106 patients with confirmed diagnosis...

article

A rationale for early extracorporeal membrane oxygenation in patients with postinfarction ventricular septal rupture complicated by cardiogenic shock

Daniel Rob, Rudolf Špunda, Jaroslav Lindner, Vilém Rohn, more

European Journal of Heart Failure > 19 > S2 > 97 - 103

Aims Ventricular septal rupture (VSR) became a rare mechanical complication of myocardial infarction in the era of percutaneous coronary interventions but is associated with extreme mortality in patients who present with cardiogenic shock (CS). Promising outcomes have been reported with the use of circulatory support allowing haemodynamic stabilization, followed by delayed repair. Therefore, we analysed...

article

Extra corporeal membrane oxygenation in the therapy of cardiogenic shock (ECMO‐CS): rationale and design of the multicenter randomized trial

Petr Ostadal, Richard Rokyta, Andreas Kruger, Dagmar Vondrakova, more

European Journal of Heart Failure > 19 > S2 > 124 - 127

Aims Extracorporeal membrane oxygenation (ECMO) in veno‐arterial configuration represents an increasingly used method for circulatory support. ECMO in cardiogenic shock offers rapid improvement of circulatory status and significant increase in tissue perfusion. Current evidence on the use of ECMO in cardiogenic shock remains insufficient. The aim of the ECMO‐CS trial is to compare two recognized...

article

Multiple thrombophilia mutations as a possible cause of premature myocardial infarction

Gabriela Dostálová, Jan Bělohlávek, Zuzana Hlubocká, Kristýna Bayerová, more

Wiener klinische Wochenschrift > 2017 > 129 > 13-14 > 503-508

Summary The incidence of acute myocardial infarction (AMI) increases with clustering of predisposing risk factors. In younger subjects with a positive family history of AMI occurring in relatives under the age of 60 years without obvious risk factors for atherosclerosis, there is a potential for strong inherited traits contributing to the risk of coronary disease. Among them there is increasing evidence...

article

Cardiac Arrest Centers

Petr Ošťádal, Richard Rokyta, Martin Balík, Jan Bělohlávek, more

Cor et Vasa > 2017 > 59 > 2 > e196-e199

article

Hyperinvasive approach prolongs the time window for favorable outcomes in refractory out-of-hospital cardiac arrest: A preliminary analysis of the “Prague OHCA Study”

Jan Belohlavek, Ondrej Smid, Ondrej Franek, Petr Kolouch

Resuscitation > 2016 > 106 > S1 > e18

article

Ethical aspects of enrolling cardiac arrest victims into a research project

Tereza Sudova, Ilona Lalova, Jan Belohlavek

Resuscitation > 2016 > 106 > S1 > e72

article

Time to start of cardiopulmonary resuscitation and the effect of target temperature management at 33°C and 36°C

Josef Dankiewicz, Hans Friberg, Jan Bělohlávek, Andrew Walden, more

Resuscitation > 2016 > 99 > C > 44-49

The optimal temperature during targeted temperature management (TTM) for comatose patients resuscitated from out-of-hospital cardiac arrest is unknown. It has been hypothesized that patients with long no-flow times, for example those without bystander CPR would have the most to gain from temperature management at lower temperatures.We analysed data from an international clinical trial randomizing...

article

Microcirculatory blood flow during cardiac arrest and cardiopulmonary resuscitation does not correlate with global hemodynamics: an experimental study

Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, more

Journal of Translational Medicine > 2016 > 14 > 1 > 1-9

Background Current research highlights the role of microcirculatory disorders in post-cardiac arrest patients. Affected microcirculation shows not only dissociation from systemic hemodynamics but also strong connection to outcome of these patients. However, only few studies evaluated microcirculation directly during cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). The aim of our experimental...

article

Mechanical chest compressions in the coronary catheterization laboratory – do not hesitate to go step further!

Jan Bělohlávek, Tomáš Kovárník

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine > 2016 > 24 > 1 > 1-2

Authors Wagner et al. in your journal demonstrated effectiveness of mechanical chest compressions in the coronary catheterization laboratory to facilitate coronary intervention and survival in patients requiring prolonged resuscitation efforts. We dare to comment on this article and advocate to use mechanical chest compressions only as a bridge to extracorporeal membrane oxygenation to completely...

article

AHEAD score — Long-term risk classification in acute heart failure

Jindrich Spinar, Jiri Jarkovsky, Lenka Spinarova, Alexandre Mebazaa, more

International Journal of Cardiology > 2016 > 202 > C > 21-26

The role of co-morbidities in the prognosis of patients hospitalized for AHF was examined using the AHEAD (A — atrial fibrillation, H — haemoglobin<130g/l for men and 120g/l for women (anaemia), E — elderly (age>70years), A — abnormal renal parameters (creatinine>130μmol/l), D — diabetes mellitus) scoring system.AHEAD — multicentre prospective Czech registry of AHF patients; GREAT registry...

article

Inducibility of ventricular fibrillation during mild therapeutic hypothermia: electrophysiological study in a swine model

Jaroslav Kudlicka, Mikulas Mlcek, Jan Belohlavek, Pavel Hala, more

Journal of Translational Medicine > 2015 > 13 > 1 > 1-8

Introduction Mild therapeutic hypothermia (MTH) is being used after cardiac arrest for its expected improvement in neurological outcome. Safety of MTH concerning inducibility of malignant arrhythmias has not been satisfactorily demonstrated. This study compares inducibility of ventricular fibrillation (VF) before and after induction of MTH in a whole body swine model and evaluates possible interaction...

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INFONA - science communication portal

Search results for: Jan Belohlavek

Initiation of sacubitril/valsartan shortly after hospitalisation for acutely decompensated heart failure in patients with newly diagnosed (de novo) heart failure: a subgroup analysis of the TRANSITION study

Initiation of sacubitril/valsartan in haemodynamically stabilised heart failure patients in hospital or early after discharge: primary results of the randomised TRANSITION study

A trial to evaluate the effect of the sodium–glucose co‐transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA‐HF)

Validation of new marker of fluid responsiveness based on Doppler assessment of blood flow velocity in superior vena cava in mechanically ventilated pigs

Position paper for the organization of ECMO programs for cardiac failure in adults

Surgical Revascularisation in the Early Phase of ST-Segment Elevation Myocardial Infarction: Haemodynamic Status is More Important Than the Timing of the Operation

Effect of a 6-month pedometer-based walking intervention on functional capacity in patients with chronic heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction: study protocol for two multicenter randomized controlled trials

Psychosocial sequelae following cardiac arrest

Cost-effectiveness of hospital treatment and outcomes of acute methanol poisoning during the Czech Republic mass poisoning outbreak

A rationale for early extracorporeal membrane oxygenation in patients with postinfarction ventricular septal rupture complicated by cardiogenic shock

Extra corporeal membrane oxygenation in the therapy of cardiogenic shock (ECMO‐CS): rationale and design of the multicenter randomized trial

Multiple thrombophilia mutations as a possible cause of premature myocardial infarction

Cardiac Arrest Centers

Hyperinvasive approach prolongs the time window for favorable outcomes in refractory out-of-hospital cardiac arrest: A preliminary analysis of the “Prague OHCA Study”

Ethical aspects of enrolling cardiac arrest victims into a research project

Time to start of cardiopulmonary resuscitation and the effect of target temperature management at 33°C and 36°C

Microcirculatory blood flow during cardiac arrest and cardiopulmonary resuscitation does not correlate with global hemodynamics: an experimental study

Mechanical chest compressions in the coronary catheterization laboratory – do not hesitate to go step further!

AHEAD score — Long-term risk classification in acute heart failure

Inducibility of ventricular fibrillation during mild therapeutic hypothermia: electrophysiological study in a swine model

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