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The capillary supply of a muscle fiber is thought to be determined by its type, oxidative capacity, size and metabolic surrounding. Size and oxidative capacity, however, differ between fiber types. To investigate which of these factors determines the capillary supply of a myofiber most we analysed in sections from human vastus lateralis (n = 11) and rat plantaris muscle (n = 8) the type, succinate...
We applied a theoretical model of muscle tissue O2 transport to investigate the effects of flow redistribution on rat soleus muscle oxygenation. The situation chosen was the anaerobic threshold where redistribution of flow is expected to have the largest impact. In the basic situation all capillaries received an equal proportion of the total flow through the tissue, resulting in 4.7% anoxic tissue...
Heterogeneity of capillary spacing may affect tissue oxygenation. The determinants of heterogeneity of capillary spacing are, however, unknown. To investigate whether 1) impaired angiogenesis and increased heterogeneity of capillary spacing delays development of hypertrophy during aging and 2) heterogeneity of capillary spacing is determined by variations in fiber size we overloaded the left m. plantaris...
Image segmentation of anatomic structures is often an essential step in medical image analysis. A variety of segmentation methods have been proposed, but none provides automatic segmentation of the thigh. In magnetic resonance images of the thigh, the segmentation is complicated by factors, such as artifacts (e.g. intensity inhomogeneity and echo) and inconsistency of soft and hard tissue compositions,...
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