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Cell‐mediated immunity directed against human papillomavirus 16 (HPV‐16) antigens was studied in 16 patients affected with classic vulvar intra‐epithelial neoplasia (VIN), also known as bowenoid papulosis (BP). Ten patients had blood lymphocyte proliferative T cell responses directed against E6/2 (14–34) and/or E6/4 (45–68) peptides, which were identified in the present study as immunodominant among...