Search results for: Sam Norton

Items from 1 to 20 out of 54 results

article

Dysregulation of immune cell and cytokine signalling correlates with clinical outcomes in myelodysplastic syndrome (MDS)

Lynette Chee, David Ritchie, Mandy Ludford‐Menting, Jane Ripley, more

European Journal of Haematology > 108 > 4 > 342 - 353

Objectives Myelodysplastic syndromes (MDS) are characterised by ineffective haematopoiesis. Although hypomethylating agents (HMA) have improved survival in higher‐risk MDS, most patients eventually succumb to progressive disease. Utilising samples collected prospectively from three MDS clinical trials, we analysed genetic and immunological biomarkers and correlated them with clinical outcomes. ...

article

SARS‐CoV‐2 infection and venous thromboembolism after surgery: an international prospective cohort study

COVIDSurg Collaborative, GlobalSurg Collaborative, Dmitri Nepogodiev, Joana FF Simoes, more

Anaesthesia > 77 > 1 > 28 - 39

SARS‐CoV‐2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri‐operative or prior SARS‐CoV‐2 were at further increased risk of venous thromboembolism. We conducted a planned sub‐study and analysis from...

article

Trajectories of alcohol misuse among the UK Armed Forces over a 12‐year period

Laura Palmer, Sam Norton, Margaret Jones, Roberto J. Rona, more

Addiction > 117 > 1 > 57 - 67

Aim To identify the main trajectories of alcohol misuse among UK military personnel from 12 years after the start of the Iraq war (2003) and the factors associated with each trajectory. Design Longitudinal cohort study with three phases of data collection (2004–06, 2007–09 and 2014–16). Setting United Kingdom. Participants Serving and ex‐serving personnel of the UK Armed Forces (n = 7111) participating...

article

Effects of pre‐operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

COVIDSurg Collaborative, GlobalSurg Collaborative, Dmitri Nepogodiev, Joana FF Simoes, more

Anaesthesia > 76 > 11 > 1454 - 1464

We aimed to determine the impact of pre‐operative isolation on postoperative pulmonary complications after elective surgery during the global SARS‐CoV‐2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors...

article

Nonserious Infections in Patients With Rheumatoid Arthritis: Results From the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Katie Bechman, Kapil Halai, Mark Yates, Sam Norton, more

Arthritis & Rheumatology > 73 > 10 > 1800 - 1809

Objective To describe the frequency and predictors of nonserious infections (NSI) and compare incidence across biologic agents within the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR‐RA). Methods The BSRBR‐RA is a prospective observational cohort study. An NSI was defined as an infection that did not require hospitalization or intravenous therapy. Infections...

article

Infant feeding practices among macrosomic infants: A prospective cohort study

Philippa Davie, Debra Bick, Dharmintra Pasupathy, Sam Norton, more

Maternal & Child Nutrition > 17 > 4 > n/a - n/a

The health benefits of breastfeeding are well recognised, but breastfeeding rates worldwide remain suboptimal. Breastfeeding outcomes have yet to be explored among women who give birth to macrosomic (birthweight ≥4000 g) infants, a cohort for whom the benefits of breastfeeding may be particularly valuable, offering protection against later‐life morbidity associated with macrosomia. This longitudinal...

article

Experiences of completed and withdrawn unspecified kidney donor candidates in the United Kingdom: An inductive thematic analysis from the BOUnD study

Mira Zuchowski, Nizam Mamode, Heather Draper, Peter Gogalniceanu, more

British Journal of Health Psychology > 26 > 3 > 958 - 976

Objectives This study sheds light on some controversial aspects of unspecified kidney donation (UKD) as well as the ways in which potential donors are screened and prepared for the donation experience and its aftermath. The aim of this study was to qualitatively investigate the experiences of individuals involved in the United Kingdom (UK) UKD scheme, including those who complete the donation, are...

article

Feasibility randomized‐controlled trial of online acceptance and commitment therapy for painful peripheral neuropathy in people living with HIV: The OPEN study

Whitney Scott, Beth J. Guildford, James Badenoch, Elizabeth Driscoll, more

European Journal of Pain > 25 > 7 > 1493 - 1507

Background Neuropathic pain negatively affects quality of life among people living with HIV (PLWH). This study examined the feasibility of conducting a full‐scale randomized‐controlled trial of online acceptance and commitment therapy (“ACT OPEN”) for neuropathic pain in PLWH. Methods Using a parallel‐groups design, thirty‐eight participants were randomized to ACT OPEN or a waitlist control (2:1)...

article

Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study

COVIDSurg Collaborative, GlobalSurg Collaborative, Dmitri Nepogodiev, Joana FF Simoes, more

Anaesthesia > 76 > 6 > 748 - 758

Peri‐operative SARS‐CoV‐2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS‐CoV‐2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre‐operative SARS‐CoV‐2 infection...

article

Venous Thromboembolism Risk With JAK Inhibitors: A Meta‐Analysis

Mark Yates, Amanda Mootoo, Maryam Adas, Katie Bechman, more

Arthritis & Rheumatology > 73 > 5 > 779 - 788

Objective JAK inhibitor therapies are effective treatment options for immune‐mediated inflammatory diseases (IMIDs), but their use has been limited by venous thromboembolism (VTE) risk warnings from licensing authorities. We undertook this study to evaluate the VTE risk of JAK inhibitors in patients with IMIDs. Methods Systematic searches of Medline and Embase databases from inception to September...

article

Poor outcome and prolonged persistence of SARS‐CoV‐2 RNA in COVID‐19 patients with haematological malignancies; King's College Hospital experience

Vallari Shah, Thinzar Ko Ko, Mark Zuckerman, Jennifer Vidler, more

British Journal of Haematology > 190 > 5 > e279 - e282

article

Childhood Maltreatment, Gender Nonconformity, and Adolescent Sexual Orientation: A Prospective Birth Cohort Study

Yin Xu, Sam Norton, Qazi Rahman

Child Development > 91 > 4 > e984 - e994

This study tested whether associations between childhood maltreatment and adolescent sexual orientation were accounted for by childhood gender nonconforming behavior (GNCB) in a prospective birth cohort (N = 5,007). Childhood parental maltreatment (physical and emotional) and GNCB were assessed on multiple occasions up to age 6 years, and sexual orientation at 15.5 years. Boys with a history of maltreatment...

article

Facial photoprotection in xeroderma pigmentosum (XP) patients: Validation of a new self‐reported questionnaire of adherence

Martha Canfield, Sam Norton, Jessica Walburn, Natalie Morrison‐Bowen, more

Photodermatology, Photoimmunology & Photomedicine > 36 > 2 > 118 - 125

Background/Purpose Adherence to photoprotection is the only way to prevent skin cancers and eye disease in xeroderma pigmentosum (XP). No validated self‐report questionnaire exists for assessing adherence to photoprotection practices in individuals with XP. We sought to validate a self‐reported measure of adherence to face photoprotection in this population. Methods Sixty six XP patients recruited...

article

A prospective study of fatigue trajectories among in‐centre haemodialysis patients

Federica Picariello, Sam Norton, Rona Moss‐Morris, Iain C Macdougall, more

British Journal of Health Psychology > 25 > 1 > 61 - 88

Objectives Fatigue is common and debilitating among dialysis patients. The aim of this study was to understand the longitudinal trajectory of fatigue and consider sociodemographic, clinical, and psychological factors that are related to variation in fatigue levels over time. Design A prospective study of fatigue with yearly assessments over 3 years among prevalent in‐centre haemodialysis (HD) patients...

article

A longitudinal birth cohort study of early life conditions, psychosocial factors, and emerging adolescent sexual orientation

Yin Xu, Sam Norton, Qazi Rahman

Developmental Psychobiology > 62 > 1 > 5 - 20

This study tested whether previously reported associations between early life factors and later adolescent sexual orientation could be replicated in another prospective birth cohort, the UK Millennium Cohort Study (MCS). We used data on 9,795 youth from the MCS. Emerging sexual orientation was assessed using measures of sexual attraction to males and females in separate items at 14 years. Factors...

article

Psychological correlates of adherence to photoprotection in a rare disease: International survey of people with Xeroderma Pigmentosum

Jessica Walburn, Martha Canfield, Sam Norton, Kirby Sainsbury, more

British Journal of Health Psychology > 24 > 3 > 668 - 686

Objectives Xeroderma pigmentosum (XP) is an extremely rare genetic disorder (approximately 100 known cases in the United Kingdom), where DNA damage caused by ultraviolet radiation in daylight cannot be repaired. Adherence to photoprotection is essential to prevent skin cancer. We investigated psychological correlates of photoprotection in the XP population of Western Europe and the United States...

article

Development and validation of the Health Visual Information Preference Scale

Annie S. K. Jones, Maria Kleinstäuber, Leslie R. Martin, Sam Norton, more

British Journal of Health Psychology > 24 > 3 > 593 - 609

Objective Patients are likely to have individual preferences for learning about health, which may influence their comprehension and utilization of health information. Some patients may prefer visual health information, which can make complex health information easier to understand. Aligning health information presentation with preferences may increase understanding and improve health outcomes, yet...

article

Acceptance and commitment therapy for chronic pain: protocol of a systematic review and individual participant data meta-analysis

Jiaxi Lin, Whitney Scott, Lewis Carpenter, Sam Norton, more

Systematic Reviews > 2019 > 8 > 1 > 1-10

Background Acceptance and commitment therapy (ACT) can be effective in treating chronic pain. Despite evidence supporting the effectiveness of ACT, uncertainties remain regarding which subgroups in the chronic pain population are likely to benefit most and least. This protocol describes the application for two meta-analytic approaches, one at the level of individual participant data and the other...

article

Reply

Faith Matcham, Matthew Hotopf, Emmert Roberts, James Galloway, more

Arthritis & Rheumatology > 71 > 6 > 1025 - 1026

article

Validation of methods for converting the original Disease Activity Score (DAS) to the DAS28

Lewis Carpenter, Sam Norton, Elena Nikiphorou, Patrick Kiely, more

Rheumatology International > 2018 > 38 > 12 > 2297-2305

The Disease Activity Score (DAS) is integral in tailoring the clinical management of rheumatoid arthritis (RA) patients and is an important measure in clinical research. Different versions have been developed over the years to improve reliability and ease of use. Combining the original DAS and the newer DAS28 data in both contemporary and historical studies is important for both primary and secondary...

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INFONA - science communication portal

Search results for: Sam Norton

Dysregulation of immune cell and cytokine signalling correlates with clinical outcomes in myelodysplastic syndrome (MDS)

SARS‐CoV‐2 infection and venous thromboembolism after surgery: an international prospective cohort study

Trajectories of alcohol misuse among the UK Armed Forces over a 12‐year period

Effects of pre‐operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

Nonserious Infections in Patients With Rheumatoid Arthritis: Results From the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis

Infant feeding practices among macrosomic infants: A prospective cohort study

Experiences of completed and withdrawn unspecified kidney donor candidates in the United Kingdom: An inductive thematic analysis from the BOUnD study

Feasibility randomized‐controlled trial of online acceptance and commitment therapy for painful peripheral neuropathy in people living with HIV: The OPEN study

Timing of surgery following SARS‐CoV‐2 infection: an international prospective cohort study

Venous Thromboembolism Risk With JAK Inhibitors: A Meta‐Analysis

Poor outcome and prolonged persistence of SARS‐CoV‐2 RNA in COVID‐19 patients with haematological malignancies; King's College Hospital experience

Childhood Maltreatment, Gender Nonconformity, and Adolescent Sexual Orientation: A Prospective Birth Cohort Study

Facial photoprotection in xeroderma pigmentosum (XP) patients: Validation of a new self‐reported questionnaire of adherence

A prospective study of fatigue trajectories among in‐centre haemodialysis patients

A longitudinal birth cohort study of early life conditions, psychosocial factors, and emerging adolescent sexual orientation

Psychological correlates of adherence to photoprotection in a rare disease: International survey of people with Xeroderma Pigmentosum

Development and validation of the Health Visual Information Preference Scale

Acceptance and commitment therapy for chronic pain: protocol of a systematic review and individual participant data meta-analysis

Reply

Validation of methods for converting the original Disease Activity Score (DAS) to the DAS28

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