Search results for: Frederik Barkhof

Items from 1 to 20 out of 524 results

article

Advanced MR Techniques for Preoperative Glioma Characterization: Part 2

Gilbert Hangel, Bárbara Schmitz‐Abecassis, Nico Sollmann, Joana Pinto, more

Journal of Magnetic Resonance Imaging > 57 > 6 > 1676 - 1695

Preoperative clinical MRI protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques in gliomas and their possible...

article

Advanced MR Techniques for Preoperative Glioma Characterization: Part 1

Lydiane Hirschler, Nico Sollmann, Bárbara Schmitz‐Abecassis, Joana Pinto, more

Journal of Magnetic Resonance Imaging > 57 > 6 > 1655 - 1675

Preoperative clinical magnetic resonance imaging (MRI) protocols for gliomas, brain tumors with dismal outcomes due to their infiltrative properties, still rely on conventional structural MRI, which does not deliver information on tumor genotype and is limited in the delineation of diffuse gliomas. The GliMR COST action wants to raise awareness about the state of the art of advanced MRI techniques...

article

The value of arterial spin labelling perfusion MRI in brain age prediction

Mathijs B. J. Dijsselhof, Michelle Barboure, Michael Stritt, Wibeke Nordhøy, more

Human Brain Mapping > 44 > 7 > 2754 - 2766

Current structural MRI‐based brain age estimates and their difference from chronological age—the brain age gap (BAG)—are limited to late‐stage pathological brain‐tissue changes. The addition of physiological MRI features may detect early‐stage pathological brain alterations and improve brain age prediction. This study investigated the optimal combination of structural and physiological arterial spin...

article

Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging

Thomas Lindner, Divya S. Bolar, Eric Achten, Frederik Barkhof, more

Magnetic Resonance in Medicine > 89 > 5 > 2024 - 2047

This article focuses on clinical applications of arterial spin labeling (ASL) and is part of a wider effort from the International Society for Magnetic Resonance in Medicine (ISMRM) Perfusion Study Group to update and expand on the recommendations provided in the 2015 ASL consensus paper. Although the 2015 consensus paper provided general guidelines for clinical applications of ASL MRI, there was...

article

Reproducibility of 3 T APT‐CEST in Healthy Volunteers and Patients With Brain Glioma

Ivar J.H.G. Wamelink, Joost P.A. Kuijer, Beatriz E. Padrela, Yi Zhang, more

Journal of Magnetic Resonance Imaging > 57 > 1 > 206 - 215

Background Amide proton transfer (APT) imaging is a chemical exchange saturation transfer (CEST) technique offering potential clinical applications such as diagnosis, characterization, and treatment planning and monitoring in glioma patients. While APT‐CEST has demonstrated high potential, reproducibility remains underexplored. Purpose To investigate whether cerebral APT‐CEST with clinically feasible...

article

Disease progression in dementia with Lewy bodies: A longitudinal study on clinical symptoms, quality of life and functional impairment

Marleen Beek, Annemartijn Unnik, Inger Steenoven, Jessica Zande, more

International Journal of Geriatric Psychiatry > 37 > 12 > n/a - n/a

Background and Objectives Dementia with Lewy Bodies (DLB) is a heterogeneous disease, with variable signs and symptoms across multiple domains. We aimed to identify associations with rate of change in cognition, everyday functioning (IADL) and quality of life (QoL). Methods We included 121 DLB patients (69 ± 6 yrs, 14%F, MMSE: 25 ± 3) in our prospective cohort (follow‐up 2 ± 1 yrs). We described...

article

Evolution from a first clinical demyelinating event to multiple sclerosis in the REFLEX trial: Regional susceptibility in the conversion to multiple sclerosis at disease onset and its amenability to subcutaneous interferon beta‐1a

Marco Battaglini, Hugo Vrenken, Riccardo Tappa Brocci, Giordano Gentile, more

European Journal of Neurology > 29 > 7 > 2024 - 2035

Background and purpose In the REFLEX trial (ClinicalTrials.gov identifier: NCT00404352), patients with a first clinical demyelinating event (FCDE) displayed significantly delayed onset of multiple sclerosis (MS; McDonald criteria) when treated with subcutaneous interferon beta‐1a (sc IFN β‐1a) versus placebo. This post hoc analysis evaluated the effect of sc IFN β‐1a on spatio‐temporal evolution...

article

Smartphone‐derived keystroke dynamics are sensitive to relevant changes in multiple sclerosis

Ka‐Hoo Lam, James Twose, Hannah McConchie, Giovanni Licitra, more

European Journal of Neurology > 29 > 2 > 522 - 534

Background To investigate smartphone keystroke dynamics (KD), derived from regular typing, on sensitivity to relevant change in disease activity, fatigue, and clinical disability in multiple sclerosis (MS). Methods Preplanned interim analysis of a cohort study with 102 MS patients assessed at baseline and 3‐month follow‐up for gadolinium‐enhancing lesions on magnetic resonance imaging, relapses,...

article

Cerebral effects of glucagon‐like peptide‐1 receptor blockade before and after Roux‐en‐Y gastric bypass surgery in obese women: A proof‐of‐concept resting‐state functional MRI study

Eelco Duinkerken, Gabriel Bernardes, Liselotte Bloemendaal, Dick J. Veltman, more

Diabetes, Obesity and Metabolism > 23 > 2 > 415 - 424

Aim To assess the effects of Roux‐en‐Y gastric bypass surgery (RYGB)‐related changes in glucagon‐like peptide‐1 (GLP‐1) on cerebral resting‐state functioning in obese women. Materials and Methods In nine obese females aged 40‐54 years in the fasted state, we studied the effects of RYGB and GLP‐1 on five a priori selected networks implicated in food‐ and reward‐related processes as well as environment...

article

Longitudinal Assessment of Multiple Sclerosis with the Brain‐Age Paradigm

James H. Cole, Joel Raffel, Tim Friede, Arman Eshaghi, more

Annals of Neurology > 88 > 1 > 93 - 105

Objective During the natural course of multiple sclerosis (MS), the brain is exposed to aging as well as disease effects. Brain aging can be modeled statistically; the so‐called “brain‐age” paradigm. Here, we evaluated whether brain‐predicted age difference (brain‐PAD) was sensitive to the presence of MS, clinical progression, and future outcomes. Methods In a longitudinal, multicenter sample of...

article

Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression

Marleen Beek, Inger Steenoven, Jessica J. Zande, Frederik Barkhof, more

Movement Disorders > 35 > 5 > 859 - 867

Objective The objective of this study was to examine clinical characteristics, cognitive decline, and predictors for time to dementia in prodromal dementia with Lewy bodies with mild cognitive impairment (MCI‐LB) compared with prodromal Alzheimer's disease (MCI‐AD). Methods We included 73 MCI‐LB patients (12% female; 68 ± 6 years; Mini Mental State Examination, 27 ± 2) and 124 MCI‐AD patients (48%...

article

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

Anna Brugulat‐Serrat, Gemma Salvadó, Grégory Operto, Raffaele Cacciaglia, more

Human Brain Mapping > 41 > 5 > 1309 - 1322

White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship between cerebral patterns of GMv and cognition in 521 (mean age 57.7 years) cognitively unimpaired middle‐aged individuals. Episodic memory (EM) was measured with the Memory Binding...

article

Hippocampal profiling: Localized magnetic resonance imaging volumetry and T2 relaxometry for hippocampal sclerosis

Sjoerd B. Vos, Gavin P. Winston, Olivia Goodkin, Hugh G. Pemberton, more

Epilepsia > 61 > 2 > 297 - 309

Objective Hippocampal sclerosis (HS) is the most common cause of drug‐resistant temporal lobe epilepsy, and its accurate detection is important to guide epilepsy surgery. Radiological features of HS include hippocampal volume loss and increased T2 signal, which can both be quantified to help improve detection. In this work, we extend these quantitative methods to generate cross‐sectional area and...

article

A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Karen K. Chung, Daniel Altmann, Frederik Barkhof, Katherine Miszkiel, more

Annals of Neurology > 87 > 1 > 63 - 74

Objective Clinical outcomes in multiple sclerosis (MS) are highly variable. We aim to determine the long‐term clinical outcomes in MS, and to identify early prognostic features of these outcomes. Methods One hundred thirty‐two people presenting with a clinically isolated syndrome were prospectively recruited between 1984 and 1987, and followed up clinically and radiologically 1, 5, 10, 14, 20,...

article

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Marcello Moccia, Ferran Prados, Massimo Filippi, Maria A. Rocca, more

Annals of Neurology > 86 > 5 > 704 - 713

Objective Spinal cord atrophy is a clinically relevant feature of multiple sclerosis (MS), but longitudinal assessments on magnetic resonance imaging using segmentation‐based methods suffer from measurement variability, especially in multicenter studies. We compared the generalized boundary shift integral (GBSI), a registration‐based method, with a standard segmentation‐based method. Methods Baseline...

article

Association between tumor location and neurocognitive functioning using tumor localization maps

Esther J. J. Habets, Eef J. Hendriks, Martin J. B. Taphoorn, Linda Douw, more

Journal of Neuro-Oncology > 2019 > 144 > 3 > 573-582

Introduction Patients with diffuse glioma often experience neurocognitive impairment already prior to surgery. Pertinent information on whether damage to a specific brain region due to tumor activity results in neurocognitive impairment or not, is relevant in clinical decision-making, and at the same time renders unique information on brain lesion location and functioning relationships. To examine...

article

Gray matter T1‐w/T2‐w ratios are higher in Alzheimer's disease

Wiesje Pelkmans, Ellen Dicks, Frederik Barkhof, Hugo Vrenken, more

Human Brain Mapping > 40 > 13 > 3900 - 3909

Myelin determines the conduction of neuronal signals along axonal connections in networks of the brain. Loss of myelin integrity in neuronal circuits might result in cognitive decline in Alzheimer's disease (AD). Recently, the ratio of T1‐weighted by T2‐weighted MRI has been used as a proxy for myelin content in gray matter of the cortex. With this approach, we investigated whether AD dementia patients...

article

Associations between quantitative [¹⁸F]flortaucipir tau PET and atrophy across the Alzheimer’s disease spectrum

Tessa Timmers, Rik Ossenkoppele, Emma E. Wolters, Sander C. J. Verfaillie, more

Alzheimer's Research & Therapy > 2019 > 11 > 1 > 1-12

Background Neuropathological studies have linked tau aggregates to neuronal loss. To describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue, Braak staging has been used. The aim of this study was to examine in vivo associations between tau pathology, quantified with [¹⁸F]flortaucipir PET in regions corresponding to Braak stages, and atrophy across the Alzheimer’s...

article

Prognostic value of Alzheimer’s biomarkers in mild cognitive impairment: the effect of age at onset

Daniele Altomare, Clarissa Ferrari, Anna Caroli, Samantha Galluzzi, more

Journal of Neurology > 2019 > 266 > 10 > 2535-2545

Objective The aim of this study is to assess the impact of age at onset on the prognostic value of Alzheimer’s biomarkers in a large sample of patients with mild cognitive impairment (MCI). Methods We measured Aβ42, t-tau, hippocampal volume on magnetic resonance imaging (MRI) and cortical metabolism on fluorodeoxyglucose–positron emission tomography (FDG-PET) in 188 MCI patients followed for at...

article

Direct comparison of [¹¹C] choline and [¹⁸F] FET PET to detect glioma infiltration: a diagnostic accuracy study in eight patients

Niels Verburg, Thomas Koopman, Maqsood Yaqub, Otto S. Hoekstra, more

EJNMMI Research > 2019 > 9 > 1 > 1-9

Background Positron emission tomography (PET) is increasingly used to guide local treatment in glioma. The purpose of this study was a direct comparison of two potential tracers for detecting glioma infiltration, O-(2-[¹⁸F]-fluoroethyl)-l-tyrosine ([¹⁸F] FET) and [¹¹C] choline. Methods Eight consecutive patients with newly diagnosed diffuse glioma underwent dynamic [¹¹C] choline and [¹⁸F] FET PET...

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INFONA - science communication portal

Search results for: Frederik Barkhof

Advanced MR Techniques for Preoperative Glioma Characterization: Part 2

Advanced MR Techniques for Preoperative Glioma Characterization: Part 1

The value of arterial spin labelling perfusion MRI in brain age prediction

Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging

Reproducibility of 3 T APT‐CEST in Healthy Volunteers and Patients With Brain Glioma

Disease progression in dementia with Lewy bodies: A longitudinal study on clinical symptoms, quality of life and functional impairment

Evolution from a first clinical demyelinating event to multiple sclerosis in the REFLEX trial: Regional susceptibility in the conversion to multiple sclerosis at disease onset and its amenability to subcutaneous interferon beta‐1a

Smartphone‐derived keystroke dynamics are sensitive to relevant changes in multiple sclerosis

Cerebral effects of glucagon‐like peptide‐1 receptor blockade before and after Roux‐en‐Y gastric bypass surgery in obese women: A proof‐of‐concept resting‐state functional MRI study

Longitudinal Assessment of Multiple Sclerosis with the Brain‐Age Paradigm

Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants

Hippocampal profiling: Localized magnetic resonance imaging volumetry and T2 relaxometry for hippocampal sclerosis

A 30‐Year Clinical and Magnetic Resonance Imaging Observational Study of Multiple Sclerosis and Clinically Isolated Syndromes

Longitudinal spinal cord atrophy in multiple sclerosis using the generalized boundary shift integral

Association between tumor location and neurocognitive functioning using tumor localization maps

Gray matter T1‐w/T2‐w ratios are higher in Alzheimer's disease

Associations between quantitative [¹⁸F]flortaucipir tau PET and atrophy across the Alzheimer’s disease spectrum

Prognostic value of Alzheimer’s biomarkers in mild cognitive impairment: the effect of age at onset

Direct comparison of [¹¹C] choline and [¹⁸F] FET PET to detect glioma infiltration: a diagnostic accuracy study in eight patients

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