Search results for: Massimo Filippi

Items from 1 to 20 out of 382 results

article

Discovering functional connectivity features characterizing multiple sclerosis phenotypes using explainable artificial intelligence

Muhammad Abubakar Yamin, Paola Valsasina, Jacopo Tessadori, Massimo Filippi, more

Human Brain Mapping > 44 > 6 > 2294 - 2306

Multiple sclerosis (MS) is a neurological condition characterized by severe structural brain damage and by functional reorganization of the main brain networks that try to limit the clinical consequences of structural burden. Resting‐state (RS) functional connectivity (FC) abnormalities found in this condition were shown to be variable across different MS phases, according to the severity of clinical...

article

Prediction of the information processing speed performance in multiple sclerosis using a machine learning approach in a large multicenter magnetic resonance imaging data set

Chiara Marzi, Alessandro d'Ambrosio, Stefano Diciotti, Alvino Bisecco, more

Human Brain Mapping > 44 > 1 > 186 - 202

Many patients with multiple sclerosis (MS) experience information processing speed (IPS) deficits, and the Symbol Digit Modalities Test (SDMT) has been recommended as a valid screening test. Magnetic resonance imaging (MRI) has markedly improved the understanding of the mechanisms associated with cognitive deficits in MS. However, which structural MRI markers are the most closely related to cognitive...

article

Maintenance of response and predictive factors of 1‐year GalcanezumAb treatment in real‐life migraine patients in Italy: The multicenter prospective cohort GARLIT study

Fabrizio Vernieri, Nicoletta Brunelli, Marilena Marcosano, Cinzia Aurilia, more

European Journal of Neurology > 30 > 1 > 224 - 234

Background and Purpose To evaluate the 1‐year effectiveness and tolerability of galcanezumab in real life and the prognostic indicators of persistent response. Methods High‐frequency episodic migraine (HFEM) and chronic migraine (CM) patients treated with galcanezumab who completed a 1‐year observation were enrolled. The primary outcomes assessed during the 12 months (V1–V12) were the change in...

article

Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double‐blind, placebo‐controlled trial

Ettore Beghi, Elisabetta Pupillo, Elisa Bianchi, Valentina Bonetto, more

European Journal of Neurology > 30 > 1 > 69 - 86

Background and purpose Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods This...

article

Signs and symptoms of COVID‐19 in patients with multiple sclerosis

Irene Schiavetti, Luca Carmisciano, Marta Ponzano, Cinzia Cordioli, more

European Journal of Neurology > 29 > 12 > 3728 - 3736

Background and purpose Clinical outcomes of multiple sclerosis (MS) patients affected by coronavirus disease 2019 (COVID‐19) have been thoroughly investigated, but a further analysis on main signs and symptoms and their risk factors still needs attention. The objective of this study was to group together and describe based on similarity the most common signs and symptoms of COVID‐19 in MS patients...

article

Guillain‐Barré syndrome and COVID‐19: A 1‐year observational multicenter study

Massimiliano Filosto, Stefano Cotti Piccinelli, Stefano Gazzina, Camillo Foresti, more

European Journal of Neurology > 29 > 11 > 3358 - 3367

Background and purpose Many single cases and small series of Guillain–Barré syndrome (GBS) associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection were reported during the coronavirus disease 19 (COVID‐19) outbreak worldwide. However, the debate regarding the possible role of infection in causing GBS is still ongoing. This multicenter study aimed to evaluate epidemiological...

article

Magnetic Resonance Imaging Evaluation of Perivascular Space Abnormalities in Neuromyelitis Optica

Laura Cacciaguerra, Antonio Carotenuto, Elisabetta Pagani, Damiano Mistri, more

Annals of Neurology > 92 > 2 > 173 - 183

Objective Astrocytes outline the perivascular space (PVS) and regulate fluid exchange through the aquaporin‐4 water channel. As neuromyelitis optica is an autoimmune astrocytopathy targeting aquaporin‐4, we hypothesized that it could be associatied with PVS abnormalities. Methods A total of 34 patients, and 46 age‐ and sex‐matched healthy controls from two independent cohorts (exploratory and validation...

article

Neuroimaging in Glucocerebrosidase‐Associated Parkinsonism: A Systematic Review

Massimo Filippi, Roberta Balestrino, Silvia Basaia, Federica Agosta

Movement Disorders > 37 > 7 > 1375 - 1393

Background Mutations in the GBA gene cause Gaucher's disease (GD) and constitute the most frequent genetic risk factor for idiopathic Parkinson's disease (iPD). Nonmanifesting carriers of GBA mutations/variants (GBA‐NMC) constitute a potential PD preclinical population, whereas PD patients carrying some GBA mutations/variants (GBA‐PD) have a higher risk of a more aggressive disease course. Different...

article

Mapping brain structure and function in professional fencers: A model to study training effects on central nervous system plasticity

Claudio Cordani, Paolo Preziosa, Roberto Gatti, Carlotta Castellani, more

Human Brain Mapping > 43 > 11 > 3375 - 3385

Brain magnetic resonance imaging (MRI) studies have shown different patterns of structural and functional reorganization in high‐level athletes compared with controls, but little is known about their relationship with interlimb coordination mechanisms. To this aim, we investigated brain structural and functional differences in high‐level fencers compared with nonathlete controls and the MRI substrates...

article

Editorial for “Amide Proton Transfer MRI Could Be Used to Evaluate the Pathophysiological Status of White Matter Hyperintensities”

Raffaello Bonacchi, Maria A. Rocca, Massimo Filippi

Journal of Magnetic Resonance Imaging > 56 > 1 > 310 - 311

article

Integrated evaluation of a panel of neurochemical biomarkers to optimize diagnosis and prognosis in amyotrophic lateral sclerosis

Yuri Matteo Falzone, Teuta Domi, Alessandra Mandelli, Laura Pozzi, more

European Journal of Neurology > 29 > 7 > 1930 - 1939

Background and purpose This study was undertaken to determine the diagnostic and prognostic value of a panel of serum biomarkers and to correlate their concentrations with several clinical parameters in a large cohort of patients with amyotrophic lateral sclerosis (ALS). Methods One hundred forty‐three consecutive patients with ALS and a control cohort consisting of 70 patients with other neurodegenerative...

article

Relation of sensorimotor and cognitive cerebellum functional connectivity with brain structural damage in patients with multiple sclerosis and no disability

Silvia Tommasin, Viktoriia Iakovleva, Maria Assunta Rocca, Costanza Giannì, more

European Journal of Neurology > 29 > 7 > 2036 - 2046

Background and purpose To investigate the relationship between the functional connectivity (FC) of the sensorimotor and cognitive cerebellum and measures of structural damage in patients with multiple sclerosis (MS) and no physical disability. Methods We selected 144 relapsing–remitting MS patients with an Expanded Disability Status Scale score of ≤1.5 and 98 healthy controls from the Italian Neuroimaging...

article

Spinal Cord Atrophy Is a Preclinical Marker of Progressive MS

Burcu Zeydan, Maria A. Rocca, Orhun H. Kantarci, Massimo Filippi

Annals of Neurology > 91 > 5 > 734 - 735

article

Improved Assessment of Longitudinal Spinal Cord Atrophy in Multiple Sclerosis Using a Registration‐Based Approach: Relevance for Clinical Studies

Paola Valsasina, Mark A. Horsfield, Alessandro Meani, Claudio Gobbi, more

Journal of Magnetic Resonance Imaging > 55 > 5 > 1559 - 1568

Background Reliable measurements of cervical cord atrophy progression may be useful for monitoring neurodegeneration in multiple sclerosis (MS). Purpose To compare a new, registration‐based (Reg) method with two existing methods (active surface [AS] and propagation segmentation [PropSeg]) to measure cord atrophy changes over time in MS. Study Type Retrospective. Subjects Cohort I: Eight healthy...

article

MAPT Q336H mutation: Intrafamilial phenotypic heterogeneity in a new Italian family

Cristina Villa, Giacomina Rossi, Ilaria Bizzozero, Sara Prioni, more

European Journal of Neurology > 29 > 5 > 1529 - 1533

Background and purpose Q336H is a rare MAPT mutation, previously found in a single patient with behavioral variant frontotemporal dementia and tau pathology (Pick bodies). Here, we describe the clinical characteristics of two members of a new family carrying the Q336H MAPT mutation. Methods Clinical, genetic, and neuroradiological assessment and follow‐up of the proband were made. Results At...

article

Comparing Natural History of Early and Late Onset Pediatric Multiple Sclerosis

Ermelinda De Meo, Massimo Filippi, Maria Trojano, Giancarlo Comi, more

Annals of Neurology > 91 > 4 > 483 - 495

Objective This study was undertaken to describe and compare disease course and prognosis of early (ie, disease onset before age 11 years) and late (ie, disease onset after age 11 years) onset pediatric multiple sclerosis. Methods Prospectively collected clinical information from Italian Multiple Sclerosis Register of 1993 pediatric multiple sclerosis patients, of whom 172 had early onset, was analyzed...

article

Rapid response to galcanezumab and predictive factors in chronic migraine patients: A 3‐month observational, longitudinal, cohort, multicenter, Italian real‐life study

Fabrizio Vernieri, Claudia Altamura, Nicoletta Brunelli, Carmelina Maria Costa, more

European Journal of Neurology > 29 > 4 > 1198 - 1208

Background and purpose A rapid response to preventive therapy is of pivotal importance in severely disabled patients with chronic migraine (CM) and diverse preventive treatment failures. This prospective, observational, multicenter real‐life study aimed at investigating the effectiveness of galcanezumab in the first 3 months of treatment of CM patients at 14 Italian headache centers. Methods All...

article

Editorial for “Utility of Advanced DWI in the Detection of Spinal Cord Microstructural Alterations and Assessment of Neurologic Function in Cervical Spondylotic Myelopathy Patients”

Raffaello Bonacchi, Maria A. Rocca, Massimo Filippi

Journal of Magnetic Resonance Imaging > 55 > 3 > 941 - 942

article

Longitudinal White Matter Damage Evolution in Parkinson's Disease

Pietro Giuseppe Scamarcia, Federica Agosta, Edoardo Gioele Spinelli, Silvia Basaia, more

Movement Disorders > 37 > 2 > 315 - 324

Background White matter hyperintensities (WMHs) have a role in cognitive impairment in normal brain aging, while the effect on Parkinson's disease (PD) progression is still controversial. Objective To investigate the longitudinal evolution of micro‐ and macrostructural damage of cerebral white matter (WM) and its relationship with the clinical picture in PD. Methods A total of 154 PD patients...

article

The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

Roberto Bergamaschi, Marta Ponzano, Irene Schiavetti, Luca Carmisciano, more

European Journal of Neurology > 29 > 2 > 535 - 542

Background and purpose Some studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m³ (PM2.5), may contribute to severe COVID‐19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID‐19 has never been explored specifically amongst patients with MS (PwMS). This retrospective...

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INFONA - science communication portal

Search results for: Massimo Filippi

Discovering functional connectivity features characterizing multiple sclerosis phenotypes using explainable artificial intelligence

Prediction of the information processing speed performance in multiple sclerosis using a machine learning approach in a large multicenter magnetic resonance imaging data set

Maintenance of response and predictive factors of 1‐year GalcanezumAb treatment in real‐life migraine patients in Italy: The multicenter prospective cohort GARLIT study

Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double‐blind, placebo‐controlled trial

Signs and symptoms of COVID‐19 in patients with multiple sclerosis

Guillain‐Barré syndrome and COVID‐19: A 1‐year observational multicenter study

Magnetic Resonance Imaging Evaluation of Perivascular Space Abnormalities in Neuromyelitis Optica

Neuroimaging in Glucocerebrosidase‐Associated Parkinsonism: A Systematic Review

Mapping brain structure and function in professional fencers: A model to study training effects on central nervous system plasticity

Editorial for “Amide Proton Transfer MRI Could Be Used to Evaluate the Pathophysiological Status of White Matter Hyperintensities”

Integrated evaluation of a panel of neurochemical biomarkers to optimize diagnosis and prognosis in amyotrophic lateral sclerosis

Relation of sensorimotor and cognitive cerebellum functional connectivity with brain structural damage in patients with multiple sclerosis and no disability

Spinal Cord Atrophy Is a Preclinical Marker of Progressive MS

Improved Assessment of Longitudinal Spinal Cord Atrophy in Multiple Sclerosis Using a Registration‐Based Approach: Relevance for Clinical Studies

MAPT Q336H mutation: Intrafamilial phenotypic heterogeneity in a new Italian family

Comparing Natural History of Early and Late Onset Pediatric Multiple Sclerosis

Rapid response to galcanezumab and predictive factors in chronic migraine patients: A 3‐month observational, longitudinal, cohort, multicenter, Italian real‐life study

Editorial for “Utility of Advanced DWI in the Detection of Spinal Cord Microstructural Alterations and Assessment of Neurologic Function in Cervical Spondylotic Myelopathy Patients”

Longitudinal White Matter Damage Evolution in Parkinson's Disease

The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

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