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Optineurin is a gene associated with normal tension glaucoma and primary open‐angle glaucoma, one of the major causes of irreversible bilateral blindness. Recently, mutations in the gene encoding optineurin were found in patients with amyotrophic lateral sclerosis (ALS). Immunohistochemical analysis showed aggregation of optineurin in skein‐like inclusions and round hyaline inclusions in the spinal...
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