Search results for: Géza Sáfrány

Items from 1 to 17 out of 17 results

article

Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells

Hargita Hegyesi, Nikolett Sándor, Géza Sáfrány, Virág Lovas, more

Stem Cell Research & Therapy > 2019 > 10 > 1 > 1-12

Stem cell-based therapies raise hope for cell replacement and provide opportunity for cardiac regenerative medicine and tumor therapy. Extracellular vesicles are a membrane-enclosed intercellular delivery system with the potential to improve the therapeutic efficacy of the treatment of a variety of disorders. As the incidence of breast cancer continues to rise, radiotherapy has emerged as a leading...

article

[P286] Study on semi-automatically evaluated micronucleus frequency changes in patients with prostate adenocarcinoma undergoing low and high dose rate brachytherapy

Timea Hulber, Enikő Kis, S. Zsuzsa Kocsis, Géza Sáfrány, more

Physica Medica > 2018 > 52 > S1 > 182

We compared the biological damaging effect of low and high dose rate brachytherapy (LDR and HDR) in healthy tissues of patients with prostate adenocarcinoma by following up the changes of DNA damage with cytokinesis-blocked micronucleus assay (CBMN) during and after the treatment.The CBMN assay was proven by literature to be good indicator of received dose during partial-body radiotherapy. The first...

article

The effect of ionizing radiation on regulatory T cells in health and disease

Eszter Persa, Andrea Balogh, Géza Sáfrány, Katalin Lumniczky

Cancer Letters > 2015 > 368 > 2 > 252-261

Treg cells are key elements of the immune system which are responsible for the immune suppressive phenotype of cancer patients. Interaction of Treg cells with conventional anticancer therapies might fundamentally influence cancer therapy response rates. Radiotherapy, apart from its direct tumor cell killing potential, has a contradictory effect on the antitumor immune response: it augments certain...

article

Growth Differentiation Factor-15 (GDF-15) is a potential marker of radiation response and radiation sensitivity

Nikolett Sándor, Boglárka Schilling-Tóth, Enikő Kis, Anett Benedek, more

Mutation Research/Genetic Toxicology and Environmental Mutagenesis > 2015 > 793 > C > 142-149

We have investigated the importance of GDF-15 (secreted cytokine belonging to the TGF-β superfamily) in low and high dose radiation-induced cellular responses. A telomerase immortalized human fibroblast cell line (F11hT) was used in the experiments. A lentiviral system encoding small hairpin RNAs (shRNA) was used to establish GDF-15 silenced cells. Secreted GDF-15 levels were measured in culture medium...

article

The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences

Katalin Lumniczky, Géza Sáfrány

Cancer Letters > 2015 > 356 > 1 > 114-125

The main antitumor efficacy of irradiation relies in its direct cytotoxic effect. Increasing evidence indicates a systemic effect of radiation though, mediated mainly by the immune system. In this review we wish to focus on the radiotherapy induced modifications of the soluble and cellular mediators of the antitumor immune response and summarize some of the mechanisms by which radiation driven local...

article

Role of GDF15 in radiosensitivity of breast cancer cells

Boglárka Schilling-Tóth, Nikolett Sándor, Fruzsina R. Walter, Alexandra Bocsik, more

Central European Journal of Biology > 2014 > 9 > 10 > 982-992

The Growth Differentiation Factor-15 gene (GDF15) is a member of TGF-b superfamily and this cytokine family is considered to be a promising target for cancer therapy. The purpose of this study was to investigate the effect of tumor derived GDF15 on proliferation and radiosensitivity of breast cancer cells in vitro and in vivo. A mouse breast cancer LM2 cell line with stable transfection of full-length...

article

The effect of ionizing radiation on the homeostasis and functional integrity of murine splenic regulatory T cells

Andrea Balogh, Eszter Persa, Enikő Noémi Bogdándi, Anett Benedek, more

Inflammation Research > 2013 > 62 > 2 > 201-212

Objective Radiotherapy affects antitumor immune responses; therefore, it is important to study radiation effects on various compartments of the immune system. Here we report radiation effects on the homeostasis and function of regulatory T (Treg) cells, which are important in down-regulating antitumor immune responses. Methods C57Bl/6 mice were irradiated with 2 Gy and alterations in splenic lymphocyte...

article

Structural analysis of oval‐cell–mediated liver regeneration in rats

Katalin Dezső, Veronika Papp, Edina Bugyik, Hargita Hegyesi, more

Hepatology > 56 > 4 > 1457 - 1467

We have analyzed the architectural aspects of progenitor‐cell–driven regenerative growth in rat liver by applying the 2‐acetaminofluorene/partial hepatectomy experimental model. The regeneration is initiated by the proliferation of so‐called oval cells. The oval cells at the proximal tips of the ductules have a more differentiated phenotype and higher proliferative rate. This preferential growth results...

article

Analysis of the common deletions in the mitochondrial DNA is a sensitive biomarker detecting direct and non-targeted cellular effects of low dose ionizing radiation

Boglárka Schilling-Tóth, Nikolett Sándor, Enikő Kis, Munira Kadhim, more

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2011 > 716 > 1-2 > 33-39

One of the key issues of current radiation research is the biological effect of low doses. Unfortunately, low dose science is hampered by the unavailability of easily performable, reliable and sensitive quantitative biomarkers suitable detecting low frequency alterations in irradiated cells. We applied a quantitative real time polymerase chain reaction (qRT-PCR) based protocol detecting common deletions...

article

Bcl-2 or bcl-XL gene therapy increases neural plasticity proteins nestin and c-fos expression in PC12 cells

Aniko Gal, Klara Pentelenyi, Viktoria Remenyi, Edina A. Wappler, more

Neurochemistry International > 2009 > 55 > 5 > 349-353

The anti-apoptotic gene replacements could be an option in preventing hypoxia-induced neuronal loss. In this paper we tested the effect of anti-apoptosis (bcl-2 and bcl-XL) gene transfer on cell plasticity. Nestin, synapsin-1 and c-fos genes and proteins expression were measured in PC12 cells in normal condition, and after hypoxia/re-oxygenation. Gene delivery results a significant increase in both...

article

Bcl-2 or Bcl-XL gene therapy reduces apoptosis and increases plasticity protein GAP-43 in PC12 cells

Aniko Gal, Geza Szilagyi, Edina Wappler, Geza Safrany, more

Brain Research Bulletin > 2008 > 76 > 4 > 349-353

The anti-apoptotic gene replacement could be an option in preventing hypoxia induced neuronal loss—necrosis and/or apoptosis. This intervention is however still controversial. In this paper, we tested the bcl-2 or bcl-XL anti-apoptotic gene transfers using an adenovirus vector in PC12 cells after hypoxia and re-oxygenation. Gene delivery results in a significant increase in both Bcl-2 and Bcl-XL proteins...

article

Triiodothyronine accelerates differentiation of rat liver progenitor cells into hepatocytes

Viktória László, Katalin Dezső, Kornélia Baghy, Veronika Papp, more

Histochemistry and Cell Biology > 2008 > 130 > 5 > 1005-1014

The 2-acetaminofluorene/partial hepatectomy (AAF/Phx) model is widely used to induce oval/progenitor cell proliferation in the rat liver. We have used this model to study the impact of a primary hepatocyte mitogen, triiodothyronine (T3) on the liver regenerating by the recruitment of oval/progenitor cells. Administration of T3 transiently accelerates the proliferation of the oval cells, which is followed...

article

Microarray analysis of radiation response genes in primary human fibroblasts

Enikö Kis, Tünde Szatmári, Márton Keszei, Róbert Farkas, more

International Journal of Radiation Oncology, Biology, Physics > 2006 > 66 > 5 > 1506-1514

Purpose: To identify radiation-induced early transcriptional responses in primary human fibroblasts and understand cellular pathways leading to damage correction.Methods and Materials: Primary human fibroblast cell lines were irradiated with 2 Gy γ-radiation and RNA isolated 2 h later. Radiation-induced transcriptional alterations were investigated with microarrays covering the entire human genome...

article

Induced acute erythema and late pigmentation may not be correlated: In regards to Perera et al. (Int J Radiat Oncol Biol Phys 2005;62:1283–1290)

Csaba Nemeskéri, Zsuzsa Póti, Árpád Mayer, Lajos Trón, more

International Journal of Radiation Oncology, Biology, Physics > 2006 > 65 > 1 > 309-310

article

Tumor radiosensitizers—current status of development of various approaches: Report of an International Atomic Energy Agency meeting

Michael R. Horsman, Lothar Bohm, Geoffrey P. Margison, Luka Milas, more

International Journal of Radiation Oncology, Biology, Physics > 2006 > 64 > 2 > 551-561

Purpose: The International Atomic Energy Agency (IAEA) held a Technical Meeting of Consultants to (1) discuss a selection of relatively new agents, not those well-established in clinical practice, that operated through a variety of mechanisms to sensitize tumors to radiation and (2) to compare and contrast their tumor efficacy, normal tissue toxicity, and status of development regarding clinical application...

article

Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes

Zsolt Csapo, Gergely Keszler, Geza Safrany, Tatjana Spasokoukotskaja, more

Biochemical Pharmacology > 2003 > 65 > 12 > 2031-2039

Deoxycytidine kinase (dCK) is a key enzyme in the intracellular metabolism of deoxynucleosides and their analogues, phosphorylating a wide range of drugs used in the chemotherapy of leukaemia and solid tumours. Previously, we found that activity of dCK can be enhanced by incubating primary cultures of lymphocytes with substrate analogues of the enzyme, as well as with various genotoxic agents. Here...

article

A review on radiogenic Lhermitte’s sign

Olga Ésik, Tibor Csere, Klára Stefanits, Zsolt Lengyel, more

Pathology & Oncology Research > 2003 > 9 > 2 > 115-120

Radiation myelopathy is a rare, but extremely serious side-effect of radiotherapy. Recovery from radiation-induced motor sequelae is rare, whereas, the regeneration of sensory losses is relatively frequent. Among the sensory radiogenic injuries of the spinal cord, Lhermitte’s sign (LS) is most frequent. This review describes the clinical picture and diagnostic imaging signs of radiogenic LS. There...

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International Journal of Radiation Oncology, Biology, Physics (3)
Cancer Letters (2)
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Brain Research Bulletin (1)
Central European Journal of Biology (1)
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis (1)
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