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Background Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with severe persistent proteinuria. DZ2002 is a reversible S-adenosyl-l-homocysteine hydrolase (SAHH) inhibitor with potent therapeutic activity against lupus nephritis in mice. However,...
Ionic nanocomposite hydrogels cross-linked by hectorite Laponite XLS with high tensile strength and ultrahigh tensibility were successfully synthesized for the first time via in situ copolymerization of N-isopropylacrylamide (NIPAm) and sodium methacrylate (SMA). The pH and temperature response, transparency, and mechanical properties of the ionic hydrogels were investigated. The results showed that...
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