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Work in the past 10 years has greatly expanded our understanding of Alzheimer's disease (AD) genetics, with more than 20 susceptibility genetic loci discovered in large genome-wide association and sequencing studies. The NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) is funded by National Institute on Aging to serve as a one-stop portal for the community to access research data and...
Background RNA molecules fold into complex three-dimensional shapes, guided by the pattern of hydrogen bonding between nucleotides. This pattern of base pairing, known as RNA secondary structure, is critical to their cellular function. Recently several diverse methods have been developed to assay RNA secondary structure on a transcriptome-wide scale using high-throughput sequencing. Each approach...
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