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Background/Aims: Studies from Japan showed that HCV-1b isolates with at least four amino acid changes within NS5A 2209-2248 compared with the prototype sequence HCV-J are more sensitive to interferon than isolates with a prototype sequence. However, the data were not unequivocally confirmed in studies from other geographical areas. These discrepancies...
Background/Aims: The combination of ribavirin and interferon alfa has potent synergistic effects in the treatment of chronic hepatitis C. The antiviral mechanism of ribavirin is unknown. We investigated whether a transient initial antiviral effect of ribavirin was sufficient to improve the response to interferon.Methods: Fifteen HCV-infected patients (ten male, five female; mean age 45.4+/-11.0 years)...
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