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Chronic lymphocytic leukemia (CLL) is one of the most frequent lymphoproliferative diseases. CLL is characterized by unusual heterogeneity, which probably reflects its biological and genetic lack of homogeneity. Clonal chromosome aberrations belong to the most important prognostic and predictive factors in CLL. This research was aimed at observing clonal evolution in CLL at the chromosomal level,...
Expression of microRNAs is altered in cancer. Circulating miRNA level assessed in body fluids commonly reflects their expression in tumor cells. In leukemias, however, both leukemic and nonleukemic cells compose circulating miRNA expression profile of peripheral blood. The latter contribution to extracellular miRNA pool may result in specific microenvironmental signaling, which promotes proliferation...
Alkohol etylowy może zmieniać funkcje poszczególnych organów i układów wewnętrznych a także strukturę i funkcje komórek. Organem najbardziej narażonym na toksyczne jego działanie jest wątroba. W hepatocytach 90% etanolu ulega enzymatycznemu utlenieniu do aldehydu octowego a następnie do kwasu octowego. Ostre i przewlekłe zatrucie etanolem prowadzi do nadmiernego nagromadzenia tam lipidów i do stłuszczenia...
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