Search results for: Shuai Zhu

Items from 1 to 20 out of 49 results

article

Involvement of SIRT3‐GSK3β deacetylation pathway in the effects of maternal diabetes on oocyte meiosis

Yongan Xin, Yifei Jin, Juan Ge, Zhenyue Huang, more

Objectives It has been widely reported that maternal diabetes impairs oocyte quality. However, the responsible mechanisms remain to be explored. In the present study, we focused on whether SIRT3‐GSK3β pathway mediates the meiotic defects in oocytes from diabetic mice. Materials and methods GSK3β functions in mouse oocyte meiosis were first detected by targeted siRNA knockdown. Spindle assembly...

article

Design and Synthesis of TY‐Phos and Application in Palladium‐Catalyzed Enantioselective Fluoroarylation of gem‐Difluoroalkenes

Tao‐Yan Lin, Zhangjin Pan, Youshao Tu, Shuai Zhu, more

Angewandte Chemie > 132 > 51 > 23157 - 23162

The first example of highly enantioselective fluoroarylation of gem‐difluoroalkenes with aryl halides is presented by using a new chiral sulfinamide phosphine (Sadphos) type ligand TY‐Phos. N‐Me‐TY‐Phos can be easily synthesized on a gram scale from readily available starting materials in three steps. Salient features of this work including readily available starting materials, good yields, high enantioselectivities...

article

Design and Synthesis of TY‐Phos and Application in Palladium‐Catalyzed Enantioselective Fluoroarylation of gem‐Difluoroalkenes

Tao‐Yan Lin, Zhangjin Pan, Youshao Tu, Shuai Zhu, more

Angewandte Chemie International Edition > 59 > 51 > 22957 - 22962

article

Meiotic block with roscovitine improves competence of porcine oocytes by fine‐tuning activities of different cyclin‐dependent kinases

Shuai Zhu, Ying‐Jun Jia, Liu‐Zhu Pan, Shuai Gong, more

Journal of Cellular Physiology > 235 > 10 > 7530 - 7540

Successful use of oocytes from small follicles (SFs) is of great importance for animal embryo production and human in vitro fertilization with reduced hormone‐related side effects. How in vitro meiotic arrest maintenance (MAM) increases the competence of oocytes is not clear. In this study, pig oocytes recovered from SF of 1–2 mm and medium‐follicles (MF) of 3–6 mm in diameter from abattoir ovaries...

article

Inhibition of microRNA‐199a‐5p ameliorates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 neurons by targeting Brg1 to activate Nrf2/HO‐1 signalling

Feng Li, Jing Liang, Hua Tong, Shuai Zhu, more

Clinical and Experimental Pharmacology and Physiology > 47 > 6 > 1020 - 1029

MicroRNAs (miRNAs) have emerged as critical regulators of neuronal survival during cerebral ischaemia/reperfusion injury. Accumulating evidence has shown that miR‐199a‐5p plays a crucial role in regulating apoptosis and survival in various cell types. However, whether miR‐199a is involved in regulating neuronal survival during cerebral ischaemia/reperfusion injury remains unknown. In this study, we...

article

Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review and meta-analysis

Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, more

Frontiers of Environmental Science & Engineering > 2020 > 14 > 1 > 1-12

The bacterial antibiotic resistome (BAR) is one of the most serious contemporary medical challenges. The BAR problem in drinking water is receiving growing attention. In this study, we focused on the distribution, changes, and health risks of the BAR throughout the drinking water treatment system. We extracted the antibiotic resistance gene (ARG) data from recent publications and analyzed ARG profiles...

article

Copper‐Catalyzed C–C Bond Cleavage/Double Cyclization of α‐Ketoamides with o‐Phenylene Diamines: Synthesis of Benzimidazo[1,2‐c]quinazolin‐6‐ones

Liang‐Hua Zou, Cheng Yan, Kai Shi, Liang Su, more

European Journal of Organic Chemistry > 2019 > 47 > 7725 - 7729

A highly regioselective C–C bond cleavage/double cyclization of α‐ketoamides with o‐phenylene diamines has been developed for the synthesis of benzimidazo[1,2‐c]quinazolin‐6‐ones. Two new C–N and one new C=N bonds are simultaneously formed in the reaction, providing the gateway to access these fused heterocyclic scaffolds via copper catalysis under air atmosphere. This new protocol provides a novel...

article

CFD-PBM Simulation and PIV Measurement of Liquid–Liquid Flow in a Continuous Stirring Settler

Xu-huan Guo, Ting-an Zhang, Qiu-yue Zhao, Zi-mu Zhang, more

JOM > 2019 > 71 > 12 > 4500-4508

The mixer settler is widely employed in the extraction and recycling of battery materials. The improvement of the separation efficiency is one of the most important issues. In order to investigate the effect of agitating speed on the flow characteristics and settling performance, both computational fluid dynamics coupled population balance model simulations and experiments with particle image velocimetry...

article

Simulation and experimental analysis of autoclave co-curing CFRP hat-stiffened panels with silicone airbag mandrels

Pingping Xie, Shuai Zhu, Yiyu Shao, Wenfei Peng, more

Iranian Polymer Journal > 2019 > 28 > 6 > 505-514

The inflatable mandrel is easy to be broken and wrinkled during the co-curing process of the hat-stiffened wall panels. The metal mandrel is difficult to demold, the water-soluble mandrel is easy to be broken, and the pressure transmission uniformity of the silicone mandrel with preformed apertures is difficult to ensure during the manufacturing process. To solve these problems, a new process for...

article

Recent Advances in Direct Functionalization of Quinones

Yijun Wang, Shuai Zhu, Liang‐Hua Zou

European Journal of Organic Chemistry > 2019 > 12 > 2179 - 2201

Developing methods for the direct functionalization of quinones for assembly of highly functionalized quinones or bioactive natural products is an essential topic in the field of direct C–H functionalization. Quinone units are key motifs in many bioactive compounds and materials, and many innovative methods have been elaborated for the generation of these units. A major part of the established synthetic...

article

Liquid–Liquid Flow in a Continuous Stirring Settler: CFD-PBM Simulation and Experimental Verification

Xu-huan Guo, Qiu-yue Zhao, Ting-an Zhang, Zi-mu Zhang, more

JOM > 2019 > 71 > 5 > 1650-1659

Mixer-settlers have been widely employed in the rare earth element separation industry. Presently, reducing the loss of reagents and occupied areas and achieving a highly efficient separation in the settler are challenging issues. In this work, we report numerical simulations of the liquid–liquid flow in a stirring settler and thereafter describe the experimental validation. A computational fluid...

article

Pd‐Catalyzed Regioselective Direct Double C–H Arylation of 6,7‐Benzindoles

Ping‐Gui Li, Youqing Yang, Shuai Zhu, Hong‐Xi Li, more

European Journal of Organic Chemistry > 2019 > 1 > 73 - 76

A palladium‐catalyzed protocol for the first direct diarylation of 6,7‐benzindoles with aryl iodides at the C4 and C5 positions was developed. The key to this strategy was the employment of pivaloyl as the directing group at the C3 position and the blocking effect at the C6 and C7 positions. The reaction proceeded very well, providing a series of diarylated 6,7‐benzindoles without prefunctionalization...

article

Evaluation of Wind Retrieval from Co-Polarization Gaofen-3 SAR Imagery Around China Seas

Weizeng Shao, Shuai Zhu, Jian Sun, Xinzhe Yuan, more

Journal of Ocean University of China > 2019 > 18 > 1 > 80-92

Gaofen-3 (GF-3) is the first Chinese space-borne satellite to carry the C-band multi-polarization synthetic aperture radar (SAR). Marine applications, i.e., winds and waves retrieved from GF-3 SAR images, have been operational since January 2017. In this study, we have collected more than 1000 quad-polarization (vertical-vertical (VV); horizontal-horizontal (HH); vertical- horizontal (VH); horizontal-vertical...

article

The Late Carboniferous Khuhu Davaa ophiolite in northeastern Mongolia: Implications for the tectonic evolution of the Mongol–Okhotsk Ocean

Ming‐Shuai Zhu, Fochin Zhang, Lai‐Cheng Miao, Munkhtsengel Baatar, more

Geological Journal > 53 > 4 > 1263 - 1278

The newly discovered Khuhu Davaa ophiolite is located in the Adaatsag suture zone, which marks the closure of the Mongol–Okhotsk Ocean in northeastern Mongolia. In this paper, we present new geochemical and SIMS zircon U–Pb data for the ophiolite to provide some constraints on the tectonic evolution of the Mongol–Okhotsk orogenic belt. Metagabbro and plagiogranite samples from the ophiolite yielded...

article

Soliton molecules in a fiber laser based on optic evanescent field interaction with WS₂

Bowen Liu, Yang Xiang, Yiyang Luo, Shuai Zhu, more

Applied Physics B > 2018 > 124 > 7 > 1-6

Passively mode-locked fiber laser serves as an ideal playground for exploring the dynamics of dissipative solitons. Recently, two-dimensional materials have attracted growing interests for their excellent optical properties in the research field of ultrafast optics. Here, we report an observation of soliton molecules in a passively mode-locked fiber laser based on optic evanescent field interaction...

article

Feature preserving multiresolution subdivision and simplification of point clouds: A conformal geometric algebra approach

Shuai Yuan, Shuai Zhu, Dong‐Shuang Li, Wen Luo, more

Mathematical Methods in the Applied Sciences > 41 > 11 > 4074 - 4087

Due to the huge volume and complex structure, simplification of point clouds is an important technique in practical applications. However, the traditional algorithms often lose geometric information and have no dynamic expanding structure. In this paper, a new simplification algorithm is proposed based on conformal geometric algebra. First of all, a multiresolution subdivision is constructed by the...

article

Multisource multisink optimal evacuation routing with dynamic network changes: A geometric algebra approach

Zhaoyuan Yu, Dongshuang Li, Shuai Zhu, Wen Luo, more

Mathematical Methods in the Applied Sciences > 41 > 11 > 4179 - 4194

In this paper, we introduced geometric algebra to develop a new multisource multisink optimal evacuation route planning method. A dynamically updatable data structure and a matrix‐based greedy searching algorithm were developed to support the dynamic evacuation route searching for multiple evacuees. Unlike most existing methods, which iteratively search the optimal path for each evacuee, our method...

article

Reciprocal loop of hypoxia‐inducible factor‐1α (HIF‐1α) and metastasis‐associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E‐cadherin transcription

Shuai Zhu, Shijiang Deng, Chi He, Mingliang Liu, more

The Journal of Pathology > 245 > 3 > 349 - 360

Metastasis‐associated protein 2 (MTA2) is overexpressed in certain malignancies, and plays important roles in tumour metastasis and progression. The present study highlights the function of MTA2 in pancreatic carcinoma through its role as a deacetylator of hypoxia‐inducible factor‐1α (HIF‐1α) and a cotranscriptional factor for E‐cadherin expression. We found that overexpression of MTA2 promoted, and...

article

Validation of significant wave height retrieval from co-polarization Chinese Gaofen-3 SAR imagery using an improved algorithm

Yexin Sheng, Weizeng Shao, Shuai Zhu, Jian Sun, more

Acta Oceanologica Sinica > 2018 > 37 > 6 > 1-10

Chinese Gaofen-3 (GF-3) is the first civilian satellite to carry C-band (5.3 GHz) synthetic aperture radar (SAR). During the period of August 2016 to December 2017, 1 523 GF-3 SAR images acquired in quad-polarization (vertical-vertical (VV), horizontal-horizontal (HH), vertical-horizontal (VH), and horizontal-vertical (HV)) mode were recorded, mostly around China’s seas. In our previous study, the...

article

Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference

Hong‐Li Xie, Shuai Zhu, Jie Zhang, Jing Wen, more

Journal of Cellular Physiology > 233 > 9 > 6952 - 6964

In previous studies on glucose metabolism during in vitro maturation, intact cumulus‐oocyte complexes (COCs) were treated with enzyme inhibitors/activators. Because inhibitors/activators may have non‐specificity and/or toxicity, and culture of COCs cannot differentiate whether glucose metabolism of cumulus cells (CCs) or that of the oocyte supports oocyte maturation, results from the previous studies...

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INFONA - science communication portal

Search results for: Shuai Zhu

Involvement of SIRT3‐GSK3β deacetylation pathway in the effects of maternal diabetes on oocyte meiosis

Design and Synthesis of TY‐Phos and Application in Palladium‐Catalyzed Enantioselective Fluoroarylation of gem‐Difluoroalkenes

Design and Synthesis of TY‐Phos and Application in Palladium‐Catalyzed Enantioselective Fluoroarylation of gem‐Difluoroalkenes

Meiotic block with roscovitine improves competence of porcine oocytes by fine‐tuning activities of different cyclin‐dependent kinases

Inhibition of microRNA‐199a‐5p ameliorates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 neurons by targeting Brg1 to activate Nrf2/HO‐1 signalling

Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review and meta-analysis

Copper‐Catalyzed C–C Bond Cleavage/Double Cyclization of α‐Ketoamides with o‐Phenylene Diamines: Synthesis of Benzimidazo[1,2‐c]quinazolin‐6‐ones

CFD-PBM Simulation and PIV Measurement of Liquid–Liquid Flow in a Continuous Stirring Settler

Simulation and experimental analysis of autoclave co-curing CFRP hat-stiffened panels with silicone airbag mandrels

Recent Advances in Direct Functionalization of Quinones

Liquid–Liquid Flow in a Continuous Stirring Settler: CFD-PBM Simulation and Experimental Verification

Pd‐Catalyzed Regioselective Direct Double C–H Arylation of 6,7‐Benzindoles

Evaluation of Wind Retrieval from Co-Polarization Gaofen-3 SAR Imagery Around China Seas

The Late Carboniferous Khuhu Davaa ophiolite in northeastern Mongolia: Implications for the tectonic evolution of the Mongol–Okhotsk Ocean

Soliton molecules in a fiber laser based on optic evanescent field interaction with WS₂

Feature preserving multiresolution subdivision and simplification of point clouds: A conformal geometric algebra approach

Multisource multisink optimal evacuation routing with dynamic network changes: A geometric algebra approach

Reciprocal loop of hypoxia‐inducible factor‐1α (HIF‐1α) and metastasis‐associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E‐cadherin transcription

Validation of significant wave height retrieval from co-polarization Chinese Gaofen-3 SAR imagery using an improved algorithm

Glucose metabolism during in vitro maturation of mouse oocytes: An study using RNA interference

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