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Bufadienolides are a type of natural steroids possessing potent antitumor activities. In this study, 4 arenobufagin structure-related bufadienolides were selected for the incubation experiments with human liver microsomes (HLMs) to investigate the structure-metabolism relationships. Arenobufagin (3) is the parent nucleus structure they shared. Both argentinogenin (1) and 4β-hydroxyl-5α-argentinogenin...
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