Search results for: Timothy J. Garrett

Items from 1 to 20 out of 38 results

article

Intensive Care Unit Delirium in Surgical Patients Is Associated with Upregulation in Tryptophan Metabolism

Stacy A. Voils, Bethany R. Shoulders, Sonal Singh, Laurence M. Solberg, more

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy > 40 > 6 > 500 - 506

Introduction In intensive care unit (ICU) patients, delirium is frequent, occurs early in ICU admission, and is associated with poor outcomes. Risk models based on clinical factors have shown variable performance in terms of predictive ability. Identification of a candidate biomarker that associates with delirium may lead to a better understanding of disease mechanism, validation biomarker studies,...

article

Exposure to recurrent hypoglycemia alters hippocampal metabolism in treated streptozotocin‐induced diabetic rats

Neelesh Dewan, Vibha Shukla, Ashish K. Rehni, Kevin B. Koronowski, more

CNS Neuroscience & Therapeutics > 26 > 1 > 126 - 135

Aims Exposure to recurrent hypoglycemia (RH) is common in diabetic patients receiving glucose‐lowering therapies and is implicated in causing cognitive impairments. Despite the significant effect of RH on hippocampal function, the underlying mechanisms are currently unknown. Our goal was to determine the effect of RH exposure on hippocampal metabolism in treated streptozotocin‐diabetic rats. Methods...

article

Impact of matrix effects and ionization efficiency in non-quantitative untargeted metabolomics

Casey A. Chamberlain, Vanessa Y. Rubio, Timothy J. Garrett

Metabolomics > 2019 > 15 > 10 > 1-9

Introduction LC–MS-based untargeted metabolomics has become increasingly popular due to the vast amount of information gained in a single analysis. Many studies utilize metabolomics to profile metabolic changes in various representative biofluids, tissues, or other sample types. Most analyses are performed measuring changes in the metabolic pool of a single biological matrix due to an altered phenotype,...

article

Software tool for internal standard based normalization of lipids, and effect of data-processing strategies on resulting values

Jeremy P. Koelmel, Jason A. Cochran, Candice Z. Ulmer, Allison J. Levy, more

BMC Bioinformatics > 2019 > 20 > 1 > 1-13

Background Lipidomics, the comprehensive measurement of lipids within a biological system or substrate, is an emerging field with significant potential for improving clinical diagnosis and our understanding of health and disease. While lipids diverse biological roles contribute to their clinical utility, the diversity of lipid structure and concentrations prove to make lipidomics analytically challenging...

article

Lipidomics for wildlife disease etiology and biomarker discovery: a case study of pansteatitis outbreak in South Africa

Jeremy P. Koelmel, Candice Z. Ulmer, Susan Fogelson, Christina M. Jones, more

Metabolomics > 2019 > 15 > 3 > 1-11

Introduction Lipidomics is an emerging field with great promise for biomarker and mechanistic studies due to lipids diverse biological roles. Clinical research applying lipidomics is drastically increasing, with research methods and tools developed for clinical applications equally promising for wildlife studies. Objectives Limited research to date has applied lipidomics, especially of the intact...

article

Metabolomic and lipidomic characterization of Oxalobacter formigenes strains HC1 and OxWR by UHPLC-HRMS

Casey A. Chamberlain, Marguerite Hatch, Timothy J. Garrett

Analytical and Bioanalytical Chemistry > 2019 > 411 > 19 > 4807-4818

Diseases of oxalate, such as nephrolithiasis and primary hyperoxaluria, affect a significant portion of the US population and have limited treatment options. Oxalobacter formigenes, an obligate oxalotrophic bacterium in the mammalian intestine, has generated great interest as a potential probiotic or therapeutic treatment for oxalate-related conditions due to its ability to degrade both exogenous...

article

Metabolomic profiles associated with bone mineral density in US Caucasian women

Qi Zhao, Hui Shen, Kuan-Jui Su, Ji-Gang Zhang, more

Nutrition & Metabolism > 2018 > 15 > 1 > 1-9

Background Individuals’ peak bone mineral density (BMD) achieved and maintained at ages 20–40 years is the most powerful predictor of low bone mass and osteoporotic fractures later in life. The aim of this study was to identify metabolomic factors associated with peak BMD variation in US Caucasian women. Methods A total of 136 women aged 20–40 years, including 65 subjects with low and 71 with high...

article

MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism

Tamaki Suganuma, Selene K. Swanson, Madelaine Gogol, Timothy J. Garrett, more

Cell Reports > 2018 > 24 > 6 > 1585-1596

Metabolic disorder has been suggested to underlie Alzheimer’s disease (AD). However, the decisive molecular linkages remain unclear. We discovered that human Molybdopterin Synthase Associating Complex, MPTAC, promotes sulfur amino acid catabolism to prevent oxidative damage from excess sulfur amino acids, which, in turn, advances fatty acid oxidation and acetyl coenzyme A (acetyl-CoA) synthesis. The...

article

Comparison of global metabolite extraction strategies for soybeans using UHPLC-HRMS

Iqbal Mahmud, Sandi Sternberg, Michael Williams, Timothy J. Garrett

Analytical and Bioanalytical Chemistry > 2017 > 409 > 26 > 6173-6180

Metabolism, downstream effectors of genomics, transcriptomics, and proteomics, can determine the potential of phenotype of an organism including plants. Profiling the global scenario of metabolism requires optimization of different solvent extraction methods. Here, we report an approach comparing three different metabolite extraction strategies, including ammonium acetate/methanol (AAM), water/methanol...

article

LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data

Jeremy P. Koelmel, Nicholas M. Kroeger, Candice Z. Ulmer, John A. Bowden, more

BMC Bioinformatics > 2017 > 18 > 1 > 1-11

Background Lipids are ubiquitous and serve numerous biological functions; thus lipids have been shown to have great potential as candidates for elucidating biomarkers and pathway perturbations associated with disease. Methods expanding coverage of the lipidome increase the likelihood of biomarker discovery and could lead to more comprehensive understanding of disease etiology. Results We introduce...

article

UHPLC-Q-Orbitrap-HRMS-based global metabolomics reveal metabolome modifications in plasma of young women after cranberry juice consumption

Haiyan Liu, Timothy J. Garrett, Zhihua Su, Christina Khoo, more

The Journal of Nutritional Biochemistry > 2017 > 45 > C > 67-76

Plasma metabolome in young women following cranberry juice consumption were investigated using a global UHPLC-Q-Orbitrap-HRMS approach. Seventeen female college students, between 21 and 29 years old, were given either cranberry juice or apple juice for three days using a cross-over design. Plasma samples were collected before and after juice consumption. Plasma metabolomes were analyzed using UHPLC-Q-Orbitrap-HRMS...

article

High Prevalence of Low Serum Biologically Active Testosterone in Older Male Veterans

Christine F. Conover, Joshua F. Yarrow, Timothy J. Garrett, Fan Ye, more

Journal of the American Medical Directors Association > 2017 > 18 > 4 > 366.e17-366.e24

Assess the prevalence of hypogonadism in older male Veterans by comparing direct measurements of total testosterone (T) and bioavailable testosterone (BioT) versus indirect BioT values derived from existing and newly developed regression analyses.Cohort study.Malcom Randall VA Medical Center, Gainesville, FL.Community-dwelling male Veterans aged 60 and older (n = 203).Total T, BioT, albumin, sex hormone–binding...

article

Expanding Lipidome Coverage Using LC-MS/MS Data-Dependent Acquisition with Automated Exclusion List Generation

Jeremy P. Koelmel, Nicholas M. Kroeger, Emily L. Gill, Candice Z. Ulmer, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 5 > 908-917

Untargeted omics analyses aim to comprehensively characterize biomolecules within a biological system. Changes in the presence or quantity of these biomolecules can indicate important biological perturbations, such as those caused by disease. With current technological advancements, the entire genome can now be sequenced; however, in the burgeoning fields of lipidomics, only a subset of lipids can...

article

Study of early stage non-small-cell lung cancer using Orbitrap-based global serum metabolomics

Agnieszka Klupczynska, Paweł Dereziński, Timothy J. Garrett, Vanessa Y. Rubio, more

Journal of Cancer Research and Clinical Oncology > 2017 > 143 > 4 > 649-659

Purpose The aim of the project was to apply ultra-high-performance liquid chromatography–quadrupole-Orbitrap-high-resolution mass spectrometry for serum metabolite profiling of non-small-cell lung cancer (NSCLC). This Orbitrap-based methodology has been applied for a study of NSCLC potential markers for the first time. Methods After extraction using protein precipitation, sera were separated on...

article

LipidPioneer : A Comprehensive User-Generated Exact Mass Template for Lipidomics

Candice Z. Ulmer, Jeremy P. Koelmel, Jared M. Ragland, Timothy J. Garrett, more

Journal of The American Society for Mass Spectrometry > 2017 > 28 > 3 > 562-565

Lipidomics, the comprehensive measurement of lipid species in a biological system, has promising potential in biomarker discovery and disease etiology elucidation. Advances in chromatographic separation, mass spectrometric techniques, and novel substrate applications continue to expand the number of lipid species observed. The total number and type of lipid species detected in a given sample are generally...

article

Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol

Liming Weng, Yan Gong, Jeffrey Culver, Stephen J. Gardell, more

Metabolomics > 2016 > 12 > 10 > 1-9

Introduction Atenolol, a commonly prescribed β blocker for hypertension, is also associated with adverse cardiometabolic effects such as hyperglycemia and dyslipidemia. Knowledge of the mechanistic underpinnings of these adverse effects of atenolol is incomplete. Objective We sought to identify biomarkers associated with risk for these untoward effects of atenolol. We measured baseline blood serum...

article

Skeletal muscle fiber analysis by atmospheric pressure scanning microprobe matrix‐assisted laser desorption/ionization mass spectrometric imaging at high mass and high spatial resolution

Yu‐Hsuan Tsai, Dhaka Ram Bhandari, Timothy J. Garrett, Christy S. Carter, more

PROTEOMICS > 16 > 11-12 > 1822 - 1824

Skeletal muscles are composed of heterogeneous muscle fibers with various fiber types. These fibers can be classified into different classes based on their different characteristics. MALDI mass spectrometric imaging (MSI) has been applied to study and visualize different metabolomics profiles of different fiber types. Here, skeletal muscles were analyzed by atmospheric pressure scanning microprobe...

article

Profiling the metabolome changes caused by cranberry procyanidins in plasma of female rats using ¹H NMR and UHPLC‐Q‐Orbitrap‐HRMS global metabolomics approaches

Haiyan Liu, Timothy J. Garrett, Fariba Tayyari, Liwei Gu

Molecular Nutrition & Food Research > 59 > 11 > 2107 - 2118

ScopeThe objective was to investigate the metabolome changes in female rats gavaged with partially purified cranberry procyanidins (PPCP) using ¹H NMR and UHPLC‐Q‐Orbitrap‐HRMS metabolomics approaches, and to identify the contributing metabolites. Methods and resultsTwenty‐four female Sprague‐Dawley rats were randomly separated into two groups and administered PPCP or partially purified apple procyanidins...

article

Comparison of blood plasma sample preparation methods for combined LC–MS lipidomics and metabolomics

Rainey E. Patterson, Antoine J. Ducrocq, Danielle J. McDougall, Timothy J. Garrett, more

Journal of Chromatography B > 2015 > 1002 > Complete > 260-266

The goal of this research was to find the most comprehensive lipid extraction of blood plasma, while also providing adequate aqueous preparation for metabolite analysis. Comparisons have been made previously of the Folch, Bligh–Dyer, and Matyash lipid extractions; furthermore, this paper provides an additional comparison of a phospholipid removal plate for analysis. This plate was used for lipid extraction...

article

Metabolomic Analysis of Oxidative and Glycolytic Skeletal Muscles by Matrix-Assisted Laser Desorption/IonizationMass Spectrometric Imaging (MALDI MSI)

Yu-Hsuan Tsai, Timothy J. Garrett, Christy S. Carter, Richard A. Yost

Journal of The American Society for Mass Spectrometry > 2015 > 26 > 6 > 915-923

Skeletal muscles are composed of heterogeneous muscle fibers that have different physiological, morphological, biochemical, and histological characteristics. In this work, skeletal muscles extensor digitorum longus, soleus, and whole gastrocnemius were analyzed by matrix-assisted laser desorption/ionization mass spectrometry to characterize small molecule metabolites of oxidative and glycolytic muscle...

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INFONA - science communication portal

Search results for: Timothy J. Garrett

Intensive Care Unit Delirium in Surgical Patients Is Associated with Upregulation in Tryptophan Metabolism

Exposure to recurrent hypoglycemia alters hippocampal metabolism in treated streptozotocin‐induced diabetic rats

Impact of matrix effects and ionization efficiency in non-quantitative untargeted metabolomics

Software tool for internal standard based normalization of lipids, and effect of data-processing strategies on resulting values

Lipidomics for wildlife disease etiology and biomarker discovery: a case study of pansteatitis outbreak in South Africa

Metabolomic and lipidomic characterization of Oxalobacter formigenes strains HC1 and OxWR by UHPLC-HRMS

Metabolomic profiles associated with bone mineral density in US Caucasian women

MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism

Comparison of global metabolite extraction strategies for soybeans using UHPLC-HRMS

LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data

UHPLC-Q-Orbitrap-HRMS-based global metabolomics reveal metabolome modifications in plasma of young women after cranberry juice consumption

High Prevalence of Low Serum Biologically Active Testosterone in Older Male Veterans

Expanding Lipidome Coverage Using LC-MS/MS Data-Dependent Acquisition with Automated Exclusion List Generation

Study of early stage non-small-cell lung cancer using Orbitrap-based global serum metabolomics

LipidPioneer : A Comprehensive User-Generated Exact Mass Template for Lipidomics

Presence of arachidonoyl-carnitine is associated with adverse cardiometabolic responses in hypertensive patients treated with atenolol

Skeletal muscle fiber analysis by atmospheric pressure scanning microprobe matrix‐assisted laser desorption/ionization mass spectrometric imaging at high mass and high spatial resolution

Profiling the metabolome changes caused by cranberry procyanidins in plasma of female rats using ¹H NMR and UHPLC‐Q‐Orbitrap‐HRMS global metabolomics approaches

Comparison of blood plasma sample preparation methods for combined LC–MS lipidomics and metabolomics

Metabolomic Analysis of Oxidative and Glycolytic Skeletal Muscles by Matrix-Assisted Laser Desorption/IonizationMass Spectrometric Imaging (MALDI MSI)

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