Hanna Piotrowska-Kempisty

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The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Malgorzata Kucinska, Helena Mieszczak, Hanna Piotrowska-Kempisty, Mariusz Kaczmarek, more

Investigational New Drugs > 2019 > 37 > 5 > 849-864

Summary It has been shown previously that molecules built on benzanilide and thiobenzanilide scaffolds possess differential biological properties including selective anticancer activity. In our previous study, we examined the cytotoxic activity and mechanism of action of the thiobenzanilide derivative N,N′-(1,2-phenylene)bis3,4,5–trifluorobenzothioamide (63 T) as a potential chemotherapeutic compound...

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Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors

Miłosz Regulski, Hanna Piotrowska-Kempisty, Wiesław Prukała, Zbigniew Dutkiewicz, more

Bioorganic & Medicinal Chemistry > 2018 > 26 > 1 > 141-151

25 new trans-stilbene and trans-stilbazole derivatives were investigated using in vitro and in silico techniques. The selectivity and potency of the compounds were assessed using commercial ELISA test. The obtained results were incorporated into 2D QSAR assay. The most promising compound 4-nitro-3′,4′,5′-trihydroxy-trans-stilbene (N1) was synthetized and its potency and selectivity were confirmed...

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Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Agnieszka Klupczynska, Anna Maria Sulej-Suchomska, Hanna Piotrowska-Kempisty, Marcin Wierzchowski, more

Journal of Chromatography B > 2017 > 1060 > C > 30-35

The synthetic resveratrol analogue DMU-212 (3,4,4′,5-tetramethoxystilbene) has been shown to possess stronger anticancer activity than resveratrol in a variety of tumour cells. To date, there has been no appropriate procedure that would ensure a reliable data about levels of metabolic products of DMU-212 in cancer cell lines. The purpose of this study was to develop a new procedure for determination...

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Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Hanna Piotrowska-Kempisty, Agnieszka Klupczyńska, Dorota Trzybulska, Katarzyna Kulcenty, more

Toxicology Letters > 2017 > 267 > C > 59-66

The role of CYP1A1 and CYP1B1 enzymes in the biotransformation and biological activity of the methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) is still elusive. Our recently published data have shown that one of the metabolites of DMU-212, 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) exerts more potent cytotoxic effects in A-2780 ovarian cancer cell line, as compared...

article

Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells

Malgorzata Kucinska, Hanna Piotrowska-Kempisty, Natalia Lisiak, Mariusz Kaczmarek, more

Toxicology in Vitro > 2016 > 37 > C > 148-161

Previously, it has been reported that molecules built on the benzanilide and thiobenzanilide scaffold are the promising groups of compounds with several biological activities including antifungal, antimycotic, antibacterial, spasmolytic, and anticancer ones. In this study the mechanism of action of one selected thiobenzanilide derivative N,N′-(1,2-phenylene)bis3,4,5–trifluorobenzothioamide (63T) with...

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Search results for: Hanna Piotrowska-Kempisty

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors

Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells

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INFONA - science communication portal

Search results for: Hanna Piotrowska-Kempisty

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors

Development and validation of HPLC–MS/MS procedure for determination of 3,4,4′,5-tetra-methoxystilbene (DMU-212) and its metabolites in ovarian cancer cells and culture medium

Role of CYP1A1 in the biological activity of methylated resveratrol analogue, 3,4,5,4′-tetramethoxystilbene (DMU-212) in ovarian cancer A-2780 and non-cancerous HOSE cells

Selective anticancer activity of the novel thiobenzanilide 63T against human lung adenocarcinoma cells

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