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Recently, a designed class of efficient analgesic drugs derived from an endogenous neuropeptide, kyotorphin (KTP, Tyr-Arg) combining C-terminal amidation (KTP-NH2) and N-terminal conjugation to ibuprofen (Ib), IbKTP-NH2, was developed. The Ib moiety is an enhancer of KTP-NH2 analgesic action. In the present study, we have tested the hypothesis that KTP-NH2 is an enhancer of the Ib anti-inflammatory...
Advances in biotechnology have made possible the production of a large number of new proteins important to the food, pharmaceutical, and chemical industry. The significance of aqueous two-phase systems (ATPSs) in downstream processing with commercial application has been reported for the separation of a large number of biopharmaceutical products. For both industrial- and laboratory-scale purposes...
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