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In this work, the computation modeling was used by the semi-empirical PM6 method that allowed to analyze the effect of temperature (308.15, 310.15 and 313.15 K, respectively) on the adsorption of metformin, glibenclamide as well as the glibenclamide/metformin complex on chitosan hydrogels crosslinked with genipin in which it was appreciated that the Gibbs free energy remained thermodynamically stable...