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The dopaminergic system is a candidate neurotransmitter system thought to be involved in the pathogenesis of depression. This study addresses the issue whether the antidepressant efficacy of serotonin reuptake inhibition is related to changes in the cerebral dopaminergic system. Cerebral dopamine-D2receptors were characterized in 13 patients with major depression using the dopamine-D2receptor antagonist...
Tachykinins such as substance P (SP) inhibit the electrically evoked release of acetylcholine (ACh) from the guinea-pig myenteric plexus. We have characterized the release-inhibitory neurokinin (NK) receptor using selective agonists for NK 1 (SP methyl ester, SPOME) and NK2 receptors [β-Ala8-NKA (4-10)], and selective antagonists for NK1 (CP96345; CP99994) and NK2 (GR94800) receptors. Myenteric...
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