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AimChymase plays a role in the augmentation of angiotensin II formation, which is involved in liver fibrosis. The therapeutic effects of a chymase inhibitor, TY‐51469, on established hepatic steatosis and fibrosis were investigated in a model of developed non‐alcoholic steatohepatitis.
MethodsHamsters were fed a normal diet or methionine‐ and choline‐deficient (MCD) diet for 12 weeks. Then, treatment...
Aim: Mast cells may be involved in the pathogenesis of nonalcoholic steatohepatitis (NASH). The mast cell protease chymase contributes to the formation of angiotensin II and matrix metalloproteinase (MMP)‐9, both of which are intimately involved in liver fibrosis. Therefore, we hypothesized that chymase plays an important role in the development of NASH.
Methods: Hamsters were fed a methionine‐...
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