Search results for: Jakub Fichna

Items from 1 to 20 out of 90 results

article

Assessment of dietary habits in inflammatory bowel disease patients: A cross‐sectional study from Poland

Michał Sienkiewicz, Patrycja Szymańska, Oliwia Maciejewska, Justyna Niewiadomska, more

Inflammatory bowel disease (IBD) has a negative impact on patients’ quality of life and affects their dietary habits. In this cross‐sectional study, we focused on the overall variety of food products consumed by IBD patients compared to a group of age‐ and sex‐matched controls; we also investigated the self‐reported, most frequently consumed and most avoided foods in relation to anticipated aggravation...

article

Brain‐derived neurotrophic factor is elevated in the blood serum of Crohn's disease patients, but is not influenced by anti‐TNF‐α treatment—A pilot study

Marcin Sochal, Ewa Małecka‐Panas, Agata Gabryelska, Jakub Fichna, more

Neurogastroenterology & Motility > 33 > 6 > n/a - n/a

Background Brain‐derived neurotrophic factor (BDNF) is associated with depression, pain, or sleep disorders, factors that are thought to be involved in the pathogenesis and clinical course of Crohn's disease (CD). Therefore, the study aimed at assessing the BDNF serum level in patients with CD and evaluates the effect of anti‐TNF‐α therapy on the BDNF level and its impact on sleep, mood, and pain...

article

Novel selective agonist of GPR18, PSB‐KK‐1415 exerts potent anti‐inflammatory and anti‐nociceptive activities in animal models of intestinal inflammation and inflammatory pain

Adam Fabisiak, Natalia Fabisiak, Anna Mokrowiecka, Ewa Malecka‐Panas, more

Neurogastroenterology & Motility > 33 > 3 > n/a - n/a

Background GPR18 is a recently deorphanized receptor which was reported to act with several endogenous cannabinoid ligands. Here, we aimed to describe the role of GPR18 in intestinal inflammation and inflammatory pain. Methods The anti‐inflammatory activity of selective GPR18 agonist, PSB‐KK‐1415, and antagonist, PSB‐CB5, was characterized in semi‐chronic and chronic mouse models of colitis induced...

article

Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies

Paula Mosińska, Marta Martín‐Ruiz, Antonio González, Visitación López‐Miranda, more

Neurogastroenterology & Motility > 31 > 9 > n/a - n/a

Background Food and diet are central issues for proper functioning of the cardiovascular (CV) system and gastrointestinal (GI) tract. We hypothesize that different types of dietary FAs affect CV parameters as well as GI motor function and visceral sensitivity. Methods Male Wistar rats were fed with control diet (CTRL), diet supplemented with 7% soybean oil (SOY), SOY + 3.5% virgin coconut oil (COCO),...

article

Role of glucagon-like peptides in inflammatory bowel diseases—current knowledge and future perspectives

Hubert Zatorski, Maciej Sałaga, Jakub Fichna

Naunyn-Schmiedeberg's Archives of Pharmacology > 2019 > 392 > 11 > 1321-1330

Inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are chronic, relapsing, intestinal inflammatory disorders with complex and yet unrevealed pathogenesis in which genetic, immunological, and environmental factors play a role. Nowadays, a higher proportion of elderly IBD patients with coexisting conditions, such as cardiovascular disease and/or diabetes is...

article

1-Substituted sialorphin analogues—synthesis, molecular modelling and in vitro effect on enkephalins degradation by NEP

Małgorzata Sobocińska, Artur Giełdoń, Jakub Fichna, Elżbieta Kamysz

Amino Acids > 2019 > 51 > 8 > 1201-1207

Rat sialorphin (Gln-His-Asn-Pro-Arg) is a natural blocker of neprilysin (NEP) that belongs to the family of endogenous opioid peptide-degrading enzymes. Studies have confirmed the efficiency of sialorphin in blocking the activity of NEP, both in vitro and in vivo. It has been demonstrated that this inhibitor has a strong analgesic, anti-inflammatory, immunological and metabolic effect either directly...

article

Enkephalinase inhibitors, potential therapeutics for the future treatment of diarrhea predominant functional gastrointestinal disorders

Agata Szymaszkiewicz, Martin Storr, Jakub Fichna, Marta Zielinska

Neurogastroenterology & Motility > 31 > 4 > n/a - n/a

The endogenous opioid system (EOS) is considered being a crucial element involved in the pathophysiology of irritable bowel syndrome (IBS) as it regulates gastrointestinal (GI) homeostasis through modulation of motility and water and ion secretion/absorption. Along with opioid receptors (ORs), the following components of EOS can be distinguished: 1. endogenous opioid peptides (EOPs), namely enkephalins,...

article

Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron

Marta Martín‐Ruíz, José A. Uranga, Paula Mosinska, Jakub Fichna, more

Neurogastroenterology & Motility > 31 > 3 > n/a - n/a

Background Cisplatin is a highly emetogenic antineoplastic drug and induces peripheral neuropathy when given in cycles. Granisetron, a 5‐HT₃ antagonist, is clinically used to prevent chemotherapy‐induced nausea/emesis and abdominal pain in irritable bowel syndrome. The effects of cisplatin on visceral sensitivity and those of granisetron in the context of cancer chemotherapy are not well known. ...

article

Focus on current and future management possibilities in inflammatory bowel disease-related chronic pain

Anna Zielińska, Maciej Sałaga, Marcin Włodarczyk, Jakub Fichna

International Journal of Colorectal Disease > 2019 > 34 > 2 > 217-227

Introduction Visceral pain is a symptom reported by over 70% of inflammatory bowel disease (IBD) sufferers. So far, a single, specific cause of this debilitating state has not been established. Chronic pain is one of the most important factors decreasing the quality of life in IBD course. Concurrently, management of pain is the most challenging issue encountered by clinicians in IBD treatment. Areas...

article

Bile acids and FXR in functional gastrointestinal disorders

Paula Mosińska, Adrian Szczepaniak, Jakub Fichna

Digestive and Liver Disease > 2018 > 50 > 8 > 795-803

Functional gastrointestinal disorders (FGIDs), such as irritable bowel syndrome (IBS) and chronic constipation (CC), are commonly diagnosed conditions in clinical practice which create a substantial global burden. Since the farnesoid X receptor (FXR) and bile acids (BAs) are responsible for maintaining homeostasis in the GI tract, any disturbances in the expression of FXR or the composition of BAs...

article

Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders

Aleksandra Tarasiuk, Paula Mosińska, Jakub Fichna

Chinese Medicine > 2018 > 13 > 1 > 1-11

Background Ayurvedic medicine is based on natural healing methods that use herbal medicine to cleanse the body of toxins and to attain physical and mental regeneration. Triphala (TLP) is one of the most important ayurvedic supplements and is believed to have a beneficial effect on the entire gastrointestinal (GI) tract. Purpose We aim to summarize available literature focused on the components of...

article

Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension—proof‐of‐concept

Adam Fabisiak, Małgorzata Sobocińska, Elżbieta Kamysz, Jakub Fichna, more

Chemical Biology & Drug Design > 92 > 1 > 1387 - 1392

Irritable bowel syndrome (IBS) is a chronic disease characterized by abdominal pain and changes in bowel habits. Patients with IBS comprise a significant portion of attendants at the outpatient clinics. Targeting intestinal opioid receptors was found successful in alleviating pain and diarrhea—two major symptoms of IBS. In this study, we aimed to evaluate a novel potential pharmacological option:...

article

Alanine scan of sialorphin and its hybrids with opiorphin: synthesis, molecular modelling and effect on enkephalins degradation

Małgorzata Sobocińska, Artur Giełdoń, Jakub Fichna, Elżbieta Kamysz

Amino Acids > 2018 > 50 > 8 > 1083-1088

Enkephalins are involved in a number of physiological processes. However, these peptides are quickly degraded by peptidases, e.g. the neutral endopeptidase (NEP). Inhibition of the enzymatic degradation of enkephalins is one of the possible approaches to prolong their activity. Selective inhibitor of NEP, sialorphin, is the attractive lead compound for enkephalins degradation studies. In this work,...

article

Tu1786 - Increased Degradation of Glugagon-Like Peptide 1 in Response to Colonic Inflammation Contributes to Impaired Glucose Metabolism in Mouse Model of Colitis

Hubert Zatorski, Maciej Salaga, Marta Zielinska, Anna Mokrowiecka, more

Gastroenterology > 2018 > 154 > 6(S1) > S-1018-S-1019

article

Novel derivatives of 1,2,3-triazole, cannabinoid-1 receptor ligands modulate gastrointestinal motility in mice

Agata Szymaszkiewicz, Marta Zielinska, Kun Li, Mani Ramanathan, more

Naunyn-Schmiedeberg's Archives of Pharmacology > 2018 > 391 > 4 > 435-444

Cannabinoid-1 (CB1) receptors are broadly distributed in the central and peripheral nervous systems; among others, they are located in the enteric nervous system. In the gastrointestinal (GI) system, they participate in regulation of intestinal motility or ion transport. The aim of our study was to assess the effect of 1,2,3-triazole derivatives (compound 1: 2-[4,5-bis(2,4-dichlorophenyl)-2H-1,2,3-triazol-2-yl]-...

article

Eliminating side effects of pain therapies

Krzysztof Różycki, Jacek Rapacz, Jakub Fichna, Piotr Kosson

World Scientific News > 2018 > 104 > 400-410

Pain is a very serious problem associated with many types of health conditions. Unfortunately, patients suffering from intense pain often give up or cut down on taking analgesics because of side effects of such treatment. New generation drugs create an opportunity for supporting therapies effectively. Persistent constipation is one of the more acute side effects of administration of opioids. This...

article

Inhibition of nuclear factor-kappaB, cyclooxygenase-2, and metalloproteinase-9 expression by flavanols from evening primrose (Oenothera paradoxa) in human colon cancer SW-480 cells

Katarzyna Owczarek, Elżbieta Hrabec, Jakub Fichna, Dorota Sosnowska, more

Journal of Functional Foods > 2017 > 37 > C > 553-563

The present study examines the chemical composition of an evening primrose flavanol preparation (EPFP) and its chemopreventive activity in colon cancer SW-480 cells. EPFP was found to inhibit SW-480 cell viability by 67% vs. controls at 150µM catechin equivalents (CE) following 72h incubation (IC₅₀=65µM CE). EPFP decreased both NF-κB protein expression (33% vs. control at 100µM CE) and phosphorylation...

article

Serum Cyclophilin A Correlates with Increased Tissue MMP-9 in Patients with Ulcerative Colitis, but Not with Crohn’s Disease

Aleksandra Piechota-Polanczyk, Marcin Włodarczyk, Aleksandra Sobolewska-Włodarczyk, Mateusz Jonakowski, more

Digestive Diseases and Sciences > 2017 > 62 > 6 > 1511-1517

Background Cyclophilin A (CyPA) is an immunomodulatory protein, high expression of which correlates with poor outcome of patients with inflammatory diseases. However, its role in inflammatory bowel disease (IBD) has not been studied. Aim This study analyzes the correlation between cyclophilin A, matrix metalloproteinase (MMP)-9, and tissue inhibitor of MMP (TIMP)/MMP-9 complexes in the inflamed...

article

Synthesis and evaluation of anti‐inflammatory properties of silver nanoparticle suspensions in experimental colitis in mice

Krzysztof Siczek, Hubert Zatorski, Anna Chmielowiec‐Korzeniowska, Jolanta Pulit‐Prociak, more

Chemical Biology & Drug Design > 89 > 4 > 538 - 547

The aim of our study was to investigate the effect of newly developed silver nanoparticle aqueous suspensions NanoAg1 and NanoAg2 in the mouse models mimicking ulcerative colitis and Crohn's disease. NanoAg1 and NanoAg2 were synthesized in aqueous medium with the involvement of tannic acid. To elucidate their anti‐inflammatory activity, semi‐chronic mouse models of inflammation induced by dextrane...

article

Flavanols from Japanese quince (Chaenomeles japonica) fruit suppress expression of cyclooxygenase-2, metalloproteinase-9, and nuclear factor-kappaB in human colon cancer cells

Katarzyna Owczarek, Elżbieta Hrabec, Jakub Fichna, Dorota Sosnowska, more

Acta Biochimica Polonica > 2017 > 64 > 3 > 567-576

Natural polyphenols and polyphenol-rich extracts have been found to possess preventive and therapeutic potential against several types of cancers, including colorectal cancer (CRC), which is an example of an inflammation-associated cancer. This study examines the chemopreventive effect of a Japanese quince (Chaenomeles japonica) fruit flavanol preparation (JQFFP) on colon cancer SW-480 cells. JQFFP,...

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INFONA - science communication portal

Search results for: Jakub Fichna

Assessment of dietary habits in inflammatory bowel disease patients: A cross‐sectional study from Poland

Brain‐derived neurotrophic factor is elevated in the blood serum of Crohn's disease patients, but is not influenced by anti‐TNF‐α treatment—A pilot study

Novel selective agonist of GPR18, PSB‐KK‐1415 exerts potent anti‐inflammatory and anti‐nociceptive activities in animal models of intestinal inflammation and inflammatory pain

Changes in the diet composition of fatty acids and fiber affect the lower gastrointestinal motility but have no impact on cardiovascular parameters: In vivo and in vitro studies

Role of glucagon-like peptides in inflammatory bowel diseases—current knowledge and future perspectives

1-Substituted sialorphin analogues—synthesis, molecular modelling and in vitro effect on enkephalins degradation by NEP

Enkephalinase inhibitors, potential therapeutics for the future treatment of diarrhea predominant functional gastrointestinal disorders

Alterations of colonic sensitivity and gastric dysmotility after acute cisplatin and granisetron

Focus on current and future management possibilities in inflammatory bowel disease-related chronic pain

Bile acids and FXR in functional gastrointestinal disorders

Triphala: current applications and new perspectives on the treatment of functional gastrointestinal disorders

Antinociceptive potency of enkephalins and enkephalinase inhibitors in the mouse model of colorectal distension—proof‐of‐concept

Alanine scan of sialorphin and its hybrids with opiorphin: synthesis, molecular modelling and effect on enkephalins degradation

Tu1786 - Increased Degradation of Glugagon-Like Peptide 1 in Response to Colonic Inflammation Contributes to Impaired Glucose Metabolism in Mouse Model of Colitis

Novel derivatives of 1,2,3-triazole, cannabinoid-1 receptor ligands modulate gastrointestinal motility in mice

Eliminating side effects of pain therapies

Inhibition of nuclear factor-kappaB, cyclooxygenase-2, and metalloproteinase-9 expression by flavanols from evening primrose (Oenothera paradoxa) in human colon cancer SW-480 cells

Serum Cyclophilin A Correlates with Increased Tissue MMP-9 in Patients with Ulcerative Colitis, but Not with Crohn’s Disease

Synthesis and evaluation of anti‐inflammatory properties of silver nanoparticle suspensions in experimental colitis in mice

Flavanols from Japanese quince (Chaenomeles japonica) fruit suppress expression of cyclooxygenase-2, metalloproteinase-9, and nuclear factor-kappaB in human colon cancer cells

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