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Abstract We suggest simple ways of implementing Peccei-Quinn (PQ) symmetry to solve the strong CP problem in renormalizable SUSY SO(10) models with a minimal Yukawa sector. Realistic fermion mass generation requires that a second pair of Higgs doublets survive down to the PQ scale. We show how unification of gauge couplings can be achieved in this context. Higgsino mediated proton decay rate is strongly...