Search results for: William M. Carroll

Items from 1 to 20 out of 38 results

article

Approaches to Understanding COVID‐19 and its Neurological Associations

Ettore Beghi, Benedict D. Michael, Tom Solomon, Erica Westenberg, more

Annals of Neurology > 89 > 6 > 1059 - 1067

There is an accumulating volume of research into neurological manifestations of coronavirus disease 2019 (COVID‐19). However, inconsistent study designs, inadequate controls, poorly validated tests, and differing settings, interventions, and cultural norms weaken study quality and comparability, hence the understanding of the spectrum, burden, and pathophysiology of these complications. Therefore,...

article

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Alan J Thompson, Brenda L Banwell, Frederik Barkhof, William M Carroll, more

The Lancet Neurology > 2018 > 17 > 2 > 162-173

The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald...

article

The need for a Global Neurology Alliance

William M. Carroll

Journal of the Neurological Sciences > 2017 > 379 > C > 321-323

With increasing rapidity of advances in neuroscience and widening gaps in the accessibility to quality neurological care the risks of unpreparedness are growing.To summarise the potential risks to the equal provision of neurological care and the resources available to improve the ability to plan and respond to the unexpected.To describe three examples of cooperative effort involving the World Federation...

article

Revising the ICD: stroke is a brain disease

Raad Shakir, Steve Davis, Bo Norrving, Wolfgang Grisold, more

The Lancet > 2016 > 388 > 10059 > 2475-2476

article

Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment

Marzena J. Fabis-Pedrini, Wen Xu, Jason Burton, William M. Carroll, more

Journal of Clinical Neuroscience > 2016 > 25 > C > 145-147

We report a case of asymptomatic progressive multifocal leukoencephalopathy (PML) detected on regular MRI screening in a 40-year-old patient with subsequent benign course with 12months follow-up. The patient had a history of aggressive inflammatory multiple sclerosis, prior mitoxantrone therapy, Stratify John Cunningham Virus test positivity (Quest Diagnostics, Madison, NJ, USA), and 5years of natalizumab...

article

Oligodendrocyte Lineage Cells in Chronic Demyelination of Multiple Sclerosis Optic Nerve

Alison Ruth Jennings, William M. Carroll

Brain Pathology > 25 > 5 > 517 - 530

Reports that chronically demyelinated multiple sclerosis brain and spinal cord lesions contained immature oligodendrocyte lineage cells have generated major interest aimed at the potential for promotion of endogenous repair. Despite the prominence of the optic nerve as a lesion site and its importance in clinical disease assessment, no detailed studies of multiple sclerosis‐affected optic nerve exist...

article

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 3 Treatment practicalities and recommendations

Simon A. Broadley, Michael H. Barnett, Mike Boggild, Bruce J. Brew, more

Journal of Clinical Neuroscience > 2014 > 21 > 11 > 1857-1865

In this third and final part of our review of multiple sclerosis (MS) treatment we look at the practical day-to-day management issues that are likely to influence individual treatment decisions. Whilst efficacy is clearly of considerable importance, tolerability and the potential for adverse effects often play a significant role in informing individual patient decisions. Here we review the issues...

article

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 1 Historical and established therapies

Simon A. Broadley, Michael H. Barnett, Mike Boggild, Bruce J. Brew, more

Journal of Clinical Neuroscience > 2014 > 21 > 11 > 1835-1846

Multiple sclerosis (MS) is a potentially life-changing immune mediated disease of the central nervous system. Until recently, treatment has been largely confined to acute treatment of relapses, symptomatic therapies and rehabilitation. Through persistent efforts of dedicated physicians and scientists around the globe for 160years, a number of therapies that have an impact on the long term outcome...

article

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and their efficacy

Simon A. Broadley, Michael H. Barnett, Mike Boggild, Bruce J. Brew, more

Journal of Clinical Neuroscience > 2014 > 21 > 11 > 1847-1856

In Part 2 of this three part review of multiple sclerosis (MS) treatment with a particular focus on the Australian and New Zealand perspective, we review the newer therapies that have recently become available and emerging therapies that have now completed phase III clinical trial programs. We go on to compare the relative efficacies of these newer and emerging therapies alongside the existing therapies...

article

The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

Wei Qiu, Kym Pham, Ian James, David Nolan, more

Journal of Neuroimmunology > 2013 > 261 > 1-2 > 92-97

Non-Human Leukocyte Antigen (HLA) genes have concomitant, although modest, effects on multiple sclerosis (MS) susceptibility; however findings have varied in different populations. Here we present the results of an association study of 16 single nucleotide polymorphisms (SNPs) in 10 non-HLA genes (IL7R, IL2RA, CLEC-16A, TYK2, CD58, IRF5, STAT3, CTLA-4, APOE, ICAM-1) in a Western Australian cohort...

article

An implantable thermoresponsive drug delivery system based on Peltier device

Rongbing Yang, Alexander V. Gorelov, Fawaz Aldabbagh, William M. Carroll, more

International Journal of Pharmaceutics > 2013 > 447 > 1-2 > 109-114

Locally dropping the temperature in vivo is the main obstacle to the clinical use of a thermoresponsive drug delivery system. In this paper, a Peltier electronic element is incorporated with a thermoresponsive thin film based drug delivery system to form a new drug delivery device which can regulate the release of rhodamine B in a water environment at 37°C. Various current signals are used to control...

article

Thermoresponsive Substrates used for the Expansion of Human Mesenchymal Stem Cells and the Preservation of Immunophenotype

Maria E. Nash, Xingliang Fan, William M. Carroll, Alexander V. Gorelov, more

Stem Cell Reviews and Reports > 2013 > 9 > 2 > 148-157

The facile regeneration of undifferentiated human mesenchymal stem cells (hMSCs) from thermoresponsive surfaces facilitates the collection of stem cells avoiding the use of animal derived cell detachment agents commonly used in cell culture. This communication proposes a procedure to fabricate coatings from commercially available pNIPAm which is both affordable and a significant simplification on...

article

Facile synthesis of thermoresponsive block copolymers of N-isopropylacrylamide using heterogeneous controlled/living nitroxide-mediated polymerizations in supercritical carbon dioxide

Padraig O’Connor, Rongbing Yang, William M. Carroll, Yury Rochev, more

European Polymer Journal > 2012 > 48 > 7 > 1279-1288

A new protocol for preparation of thermoresponsive poly(N-isopropylacrylamide, NIPAM) containing block copolymers is described. It involves two successive heterogeneous controlled/living nitroxide-mediated polymerizations (NMPs) in supercritical carbon dioxide (scCO ₂ ) using N-tert-butyl-N-[1-diethylphosphono-(2,2-dimethylpropyl)]nitroxide (SG1), as the nitroxide. Precipitation NMPs give...

article

A mathematical model for pulsatile release: Controlled release of rhodamine B from UV-crosslinked thermoresponsive thin films

Rongbing Yang, Tuoi Vo T. N., Alexander V. Gorelov, Fawaz Aldabbagh, more

International Journal of Pharmaceutics > 2012 > 427 > 2 > 320-327

A controlled drug delivery system fabricated from a thermoresponsive polymer was designed to obtain a pulsatile release profile which was triggered by altering the temperature of the dissolution medium. Two stages of release behaviour were found: fast release for a swollen state and slow (yet significant and non-negligible) release for a collapsed state. Six cycles of pulsatile release between 4°C...

article

Straightforward, One-Step Fabrication of Ultrathin Thermoresponsive Films from Commercially Available pNIPAm for Cell Culture and Recovery

Maria E. Nash, William M. Carroll, Natalia Nikoloskya, Rongbing Yang, more

ACS Applied Materials & Interfaces > 2011 > 3 > 6 > 1980 - 1990

article

Spinal cord involvement in multiple sclerosis: A correlative MRI and high-resolution HLA-DRB1 genotyping study

Wei Qiu, Sonja Raven, Ian James, Yuebei Luo, more

Journal of the Neurological Sciences > 2011 > 300 > 1-2 > 114-119

There have been few magnetic resonance imaging (MRI) studies of the spinal cord in large multiple sclerosis (MS) patient cohorts and little is known about correlations between cord lesions and human leukocyte antigen (HLA) alleles.To investigate the spectrum of MRI changes in the spinal cord in MS and associations with the HLA-DRB1 genotype.Two hundred and fifty two consecutive MS patients from the...

article

61. Hypothalamic lesions and association with HLA-DRB1 alleles in Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO)

Wei Qiu, Sonja Raven, Jing-Shan Wu, William M. Carroll, more

Journal of Clinical Neuroscience > 2010 > 17 > 12 > 1628

article

60. HLA-DRB1 alleles are determinants of spinal cord pathology in Multiple Sclerosis (MS)

Wei Qiu, Sonja Raven, Jing-Shan Wu, Yuebei Luo, more

Journal of Clinical Neuroscience > 2010 > 17 > 12 > 1628

article

Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia

Wei Qiu, Jing-Shan Wu, Alison Castley, Ian James, more

Journal of Clinical Neuroscience > 2010 > 17 > 8 > 1009-1013

We aimed to characterize the clinical profile and human leukocyte antigen (HLA)-DRB1 genotype of patients with late onset multiple sclerosis (LOMS) in Western Australia. The clinical features, laboratory studies and HLA-DRB1 alleles were analysed in patients with multiple sclerosis (MS) with onset over 50years of age and compared with 100 patients with early onset MS (EOMS). Of a cohort of 829 patients...

chapter

Neuromyelitis Optica (NMO) or Devic's Disease

William M. Carroll

International Neurology > Demyelinating Disorders > 375 - 377

This chapter contains sections titled: Introduction Clinical and laboratory features and diagnostic criteria Pathology and pathogenesis Epidemiology and immunogenetics Relationship to other inflammatory demyelinating diseases and treatment Conclusion Further reading

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Search results for: William M. Carroll

Approaches to Understanding COVID‐19 and its Neurological Associations

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

The need for a Global Neurology Alliance

Revising the ICD: stroke is a brain disease

Asymptomatic progressive multifocal leukoencephalopathy during natalizumab therapy with treatment

Oligodendrocyte Lineage Cells in Chronic Demyelination of Multiple Sclerosis Optic Nerve

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 3 Treatment practicalities and recommendations

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 1 Historical and established therapies

Therapeutic approaches to disease modifying therapy for multiple sclerosis in adults: An Australian and New Zealand perspective Part 2 New and emerging therapies and their efficacy

The influence of non-HLA gene polymorphisms and interactions on disease risk in a Western Australian multiple sclerosis cohort

An implantable thermoresponsive drug delivery system based on Peltier device

Thermoresponsive Substrates used for the Expansion of Human Mesenchymal Stem Cells and the Preservation of Immunophenotype

Facile synthesis of thermoresponsive block copolymers of N-isopropylacrylamide using heterogeneous controlled/living nitroxide-mediated polymerizations in supercritical carbon dioxide

A mathematical model for pulsatile release: Controlled release of rhodamine B from UV-crosslinked thermoresponsive thin films

Straightforward, One-Step Fabrication of Ultrathin Thermoresponsive Films from Commercially Available pNIPAm for Cell Culture and Recovery

Spinal cord involvement in multiple sclerosis: A correlative MRI and high-resolution HLA-DRB1 genotyping study

61. Hypothalamic lesions and association with HLA-DRB1 alleles in Multiple Sclerosis (MS) and Neuromyelitis Optica (NMO)

60. HLA-DRB1 alleles are determinants of spinal cord pathology in Multiple Sclerosis (MS)

Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia

Neuromyelitis Optica (NMO) or Devic's Disease

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