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Histamine is a multifunctional biogenic amine with relevant roles in intercellular communication, inflammatory processes and many emergent pathologies. Histamine biosynthesis depends on the single decarboxylation of the amino acid histidine. In Gram-negative bacteria and animals, this reaction is carried out by a PLP-dependent histidine decarboxylase activity (HDC, EC 4.1.1.22), an enzyme that has...
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