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Rapid antimicrobial susceptibility tests (ASTs) are essential tool for proper treatment of patients infected by Yersinia pestis (Y. pestis), the causative agent of plague, or for post-exposure prophylaxis of a population exposed to a naturally acquired or deliberately prepared resistant variant. The standard AST of Y. pestis is based on bacterial growth and requires 24–48 h of incubation in addition...
Antibiotics are considered as an effective treatment against Francisella tularensis (FT), the causative agent of Tularemia. In this study we compared the efficacy of two types of antibiotics: the bacteriostatic doxycycline and the bactericidic ciprofloxacin, for protection against intranasal FT-LVS in a mouse infection model. Antibiotic treatments were initiated 24–72 h post- bacterial infection,...
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