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Background
Modern disease staging systems have restructured human papillomavirus (HPV)‐negative (HPV−) and HPV‐positive (HPV+) oropharyngeal carcinoma (OPC) into distinct pathologic nodal systems. Given that quantitative lymph node (LN) burden is the dominant prognostic factor in most head and neck cancers, we investigated whether HPV− and HPV+ OPC warrant divergent pathologic nodal classification...
BACKGROUND
Multidisciplinary management of head and neck cancer (HNC) must reconcile increasingly sophisticated subspecialty care with timeliness of care. Prior studies examined the individual effects of delays in diagnosis‐to‐treatment interval, postoperative interval, and radiation interval but did not consider them collectively. The objective of the current study was to investigate the combined...
BACKGROUND
Current lymph node (LN) staging for salivary gland cancer (SGC) is extrapolated from mucosal head and neck squamous cell carcinoma. However, given its unique biology and clinical behavior, it is possible that a SGC‐specific LN staging system would be more accurate.
METHODS
Patients from the National Cancer Data Base with nonmetastatic SGC of the head and neck who were diagnosed from...
BACKGROUND
There is increasing evidence that primary tumor ablation can improve survival for some cancer patients with distant metastases. This may be particularly applicable to head and neck squamous cell carcinoma (HNSCC) because of its tropism for locoregional progression.
METHODS
This study included patients with metastatic HNSCC undergoing systemic therapy identified in the National Cancer...
BACKGROUND
The treatment of head and neck cancers is complex and associated with significant morbidity, requiring multidisciplinary care and physician expertise. Thus, facility characteristics, such as clinical volume and academic status, may influence outcomes.
METHODS
The current study included 46,567 patients taken from the National Cancer Data Base who were diagnosed with locally advanced invasive...
BACKGROUND
Single‐modality radiotherapy is considered a standard‐of‐care option for certain stage III, T1‐2N1 head and neck squamous cell carcinomas (HNSCCs). The role of concomitant chemoradiation is not well established because there have been no studies comparing chemoradiation with radiation alone in this population.
METHODS
This study analyzed patients in the National Cancer Data Base with...
BACKGROUNDIn considering treatment allocation for patients with early esophageal adenocarcinoma, the incidence of lymph node metastasis is a critical determinant; however, this has not been well defined or stratified by the relevant clinical predictors of lymph node spread.
METHODSData from the Surveillance, Epidemiology, and End Results database of the National Cancer Institute were abstracted from...
BACKGROUNDThe discovery of oncogenic drivers has ushered in a new era for lung cancer, but the role of these mutations in different racial/ethnic minorities has been understudied. The Lung Cancer Mutation Consortium 1 (LCMC1) database was investigated to evaluate the frequency and impact of oncogenic drivers in lung adenocarcinomas in the racial/ethnic minority patient population.
METHODSPatients...
BACKGROUNDThe last 3 decades have witnessed limited therapeutic advances in small cell lung cancer (SCLC) management. This study evaluated real‐world trends in the use of systemic therapies and the impact on patient outcomes in the United States.
METHODSThe Surveillance, Epidemiology, and End Results–Medicare database was used to find patients diagnosed with SCLC between 1985 and 2005. The 1985‐1990...
BACKGROUNDAlthough heregulin and human epidermal growth factor receptor 3 (HER3) are frequently expressed at high levels in patients with head and neck cancer, their prognostic value remains unclear. The authors explored the prognostic significance of heregulin/HER3 expression in patients with oropharyngeal squamous cell carcinoma (OPSCC), taking into account other HER family members as well as p16...
BACKGROUNDMalignant bowel obstruction affects an estimated 3% to 15% of patients with cancer, with a mean survival of <4 weeks reported in patients with inoperable malignant bowel obstruction. In the current study, the authors assessed predictors of survival and the influence of treatment modality in US patients with cancer who were hospitalized for malignant bowel obstruction.
METHODSAll the...
BACKGROUNDThe categories of the International Myeloma Working Group (IMWG) response criteria for multiple myeloma are based on the magnitude of the change in paraprotein and the normalization of the free light chain ratio (rFLC). However, the relationship between the response by these biomarkers and clinical outcomes has not been validated with novel compounds in the phase 1 setting. Early response...
BACKGROUNDTo understand the mechanism of frequent and early lymph node metastasis in high‐risk human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC), this study investigated whether β‐catenin is regulated by the HPV oncoprotein and contributes to OPSCC metastasis.
METHODSExpression levels of p16, β‐catenin, and epidermal growth factor receptor (EGFR) were examined in...
BACKGROUNDThe current study was conducted to develop a multifactorial statistical model to predict the specific head and neck (H&N) tumor site origin in cases of squamous cell carcinoma confined to the cervical lymph nodes (“unknown primaries”).
METHODSThe Surveillance, Epidemiology, and End Results (SEER) database was analyzed for patients with an H&N tumor site who were diagnosed between...
BACKGROUNDProphylactic cranial irradiation (PCI) improves survival in patients with limited‐stage small cell lung cancer (SCLC) who have a complete response to chemotherapy and radiotherapy, yet to the best of the authors' knowledge, data specific to the elderly population are lacking.
METHODSUsing the Surveillance, Epidemiology, and End Results (SEER) database, the authors identified 1926 patients...
BACKGROUND:Reliable predictive biomarkers are required to address the challenge of disease recurrence after thyroid cancer surgery. For this study, the authors assessed the association of cellular‐based and serum‐based immunologic mediators with thyroid cancer recurrence.
METHODS:Leukocyte subset counts and immune regulatory cytokine levels were determined in peripheral blood samples using multiparameter...
BACKGROUND:The use of radiation therapy (RT) “cone‐down” boost to reduce high‐dose treatment volumes according to tumor response to induction chemotherapy in patients with pediatric rhabdomyosarcoma (RMS) may reduce treatment morbidity, yet the impact on tumor control is unknown.
METHODS:Fifty‐five children, including 18 (33%) with parameningeal (PM) RMS and 37 (67%) with non‐PM RMS, who received...
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