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ObjectivesA novel magnetic targeting anti‐tumour drug delivery system (Fe3O4/KCTS‐CHE) was designed using magnetic Fe3O4/chitosan alpha‐ketoglutaric acid (Fe3O4/KCTS) as carrier and chelerythrine (CHE) as an anti‐tumour drug model. Moreover, the anti‐tumour activities and mechanisms of Fe3O4/KCTS‐CHE were investigated.
MethodsThe preparation conditions of Fe3O4/KCTS‐CHE microspheres were optimized...
ObjectivesmiRNAs play crucial roles in human tumourigenesis. This study was performed to measure expression and function of miR‐762 in breast cancer.
Materials and methodsExpression of miR‐762 in breast tissues and cell lines (SK‐BR‐3, DA‐MB‐435s, MCF‐7 and MDA‐MB‐231, HBL‐100) was measured by using real‐time RT‐PCR. We restored expression of miR‐762 in MCF‐7 cells to measure its functional roles...
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