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In vivo Magnetic Resonance Spectroscopy (MRS) is the only technique that can non-invasely detect metabolites at arbitrary locations inside humans and animals. Because metabolites serve as markers of disease, estimation of their in vivo concentrations (quantitation) is important. Metabolite quantitation suffers when the model function of the in vivo MRS signal is only partially known. The present work...
Metabolites can serve as biomarkers. Estimation of metabolite concentrations from an in vivo MRS signal often uses a reference signal from water for correction of the spectral lineshape. When no reference signal is available, other methods must be applied. The present work concerns semi-parametric estimation of the perturbed line-shape from simulated signals of the metabolites themselves. Errors are...
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