Search results for: Dana Kaplan

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Domestic minor sex trafficking: An emerging health crisis

Dana Kaplan, Kathleen Kemp

The Brown University Child and Adolescent Behavior Letter > 31 > 7 > 1 - 6

The commercial sexual exploitation of children (CSEC) occurs when a person induces a minor to engage in a sex act in exchange for remuneration in the form of money, food, shelter or another valued entity. Domestic minor sex trafficking (DMST) refers to the commercial sexual exploitation of children who live within U.S. borders. This term assists in differentiating these victims from those who have...

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Xenobiotic phenols in early pregnancy amniotic fluid

Stephanie M. Engel, Brynn Levy, Zhisong Liu, Dana Kaplan, more

Reproductive Toxicology > 2006 > 21 > 1 > 110-112

We found detectable levels of three phytoestrogens (enterolactone, daidzein and genistein) and bisphenol A (BPA) in 21 residual amniotic fluid specimens that were collected before 20 weeks gestation. Samples were obtained by amniocentesis from women who were referred to the Mount Sinai Medical center because of advanced maternal age. Phytoestrogens were present in higher concentrations than BPA. Enterolactone...

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Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents

Dov Barak, Arie Ordentlich, Dana Kaplan, Chanoch Kronman, more

Chemico-Biological Interactions > 2005 > 157-158 > Complete > 219-226

Determination of the 3D-structure of acetylcholinesterase (AChE) of Torpedo californica over a decade ago, and more recently that of human enzyme together with extensive targeted mutagenesis of the mammalian AChEs led to a fine mapping of the multiple functional domains within the active center of the enzyme. Many of the contributions of this active center architecture to accommodation of noncovalent...

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Functional requirements for the optimal catalytic configuration of the AChE active center

Avigdor Shafferman, Dov Barak, Dana Kaplan, Arie Ordentlich, more

Chemico-Biological Interactions > 2005 > 157-158 > Complete > 123-131

Functional analysis of the HuAChE active center architecture revealed that accommodation of structurally diverse substrates and other ligands is achieved through interactions with specific subsites such as the acyl pocket, cation binding site, hydrophobic site or the oxyanion hole. Recent studies have begun to unravel the role of this active center architecture in maintaining the optimal catalytic...

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The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers

Arie Ordentlich, Dov Barak, Gali Sod-Moriah, Dana Kaplan, more

Chemico-Biological Interactions > 2005 > 157-158 > Complete > 191-198

The reactivity of human acetylcholinesterase (HuAChE) toward the chemical warfare agent VX {O-ethyl S-[2-(diisopropylamino)ethyl] methyl-phosphonothioate} and its stereoselectivity toward the P ^S -enantiomer were investigated by examining the reactivity of HuAChE and its mutant derivatives toward purified enantiomers of VX and its noncharged isostere nc-VX [O-ethyl S-(3-isopropyl-4-methyl-pentyl)...