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The inflammatory cytokines can initiate nerve cell degeneration and enhance the plaque production typically found in Alzheimer's disease (AD). Interleukin-18 (IL-18) is an inflammatory cytokine, which can induce the expression of interferon-γ. This interleukin shares similarities with the IL-1 family of proteins. Like IL-1β, IL-18 is cleaved by caspase-1 (ICE) to an active secreted form. We examined...
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