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Although animal models suggest that alcohol dependence (AD) is associated with elevations in the number of serotonin 1B receptors (5-HT 1B R), 5-HT 1B R levels have not been investigated in people with AD. The selective 5-HT 1B R antagonist radioligand, [ 11 C]P943, permits in vivo assessment of central 5-HT 1B R binding potential (BP ND ) with positron...
Objectives: The role of the norepinephrine transporter (NET) in cocaine dependence has never been demonstrated via in vivo imaging due to the lack of suitable NET radioligands. Here we report our preliminary studies evaluting the NET in individuals with cocaine dependence (COC) in comparison to healthy controls (HC) using (S,S)‐[11C]methylreboxetine ([11C]MRB), the most promising C‐11 labeled positron‐emission...
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