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Mortality in acute respiratory distress syndrome remains high with no effective pharmacological therapies. The syndrome is characterised by dysregulated neutrophilic inflammation and tissue damage, which leads to the release of various factors including mitochondrial formylated peptides to drive neutrophil migration to sites of inflammation. This study investigated the importance of mitochondrial...
Synergistic engagement of the B cell receptor (BCR) and Toll-like receptor 9 (TLR9) in response to DNA-containing antigens underlies the production of many autoantibodies in systemic autoimmune diseases. However, the molecular basis of this synergistic engagement is not known. Given that these receptors are spatially segregated, with the BCR on the cell surface and TLR9 in endocytic vesicles, achieving...
The neurovirulent retroviruses FrCasE and Moloney MLV-ts1 cause noninflammatory spongiform neurodegeneration in mice, manifested clinically by progressive spasticity and paralysis. Neurons have been thought to be the primary target of toxicity of these viruses. However the neurons themselves appear not to be infected, and the possible indirect mechanisms driving the neuronal toxicity have remained...
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