Search results for: Aleksandra Piotrowska

Items from 1 to 20 out of 23 results

article

Association between grade brain tumors and the interleukin‐10 receptor subunit alpha based on surface‐enhanced Raman spectroscopy and multivariate analysis

Aneta Aniela Kowalska, Marta Czaplicka, Ariadna B. Nowicka, Krzysztof Niciński, more

Journal of Raman Spectroscopy > 52 > 11 > 1788 - 1797

We present herein a label‐free method based on surface‐enhanced Raman spectroscopy (SERS) that was performed using a silicon‐based SERS platform. The differentiation between primary and secondary brain tumors SERS data was completed partial least squares (PLS) method with a very high 85% of accuracy (in only first and second factors), whereas calculated using principal component analysis (PCA) method...

article

Long‐term stiripentol administration, an anticonvulsant drug, does not impair sperm parameters in rats

Agnieszka Matuszewska, Beata Nowak, Adam Szeląg, Anna Merwid‐Ląd, more

Andrologia > 53 > 6 > n/a - n/a

In this study, we investigated the influence of long‐term administration of stiripentol on sex hormones and semen quality in young Wistar rats. Investigated animals received for 6 months either stiripentol or saline solution. After one month, stiripentol increased temporarily serum level of testosterone (p < 0.05) and FSH (p < 0.01). However, after 6 months levels of testosterone, FSH, LH, prolactin...

article

Immunohistochemical and ultrastructural analysis of sporadic inclusion body myositis: a case series

Katarzyna Haczkiewicz, Agata Sebastian, Aleksandra Piotrowska, Maria Misterska-Skóra, more

Rheumatology International > 2019 > 39 > 7 > 1291-1301

Sporadic inclusion body myositis (s-IBM) is a progressive, skeletal muscle disease with poor prognosis. However, establishing the final diagnosis is difficult because of the lack of clear biomarkers in the blood serum and very slow development of clinical symptoms. Moreover, most other organs function normally without any disturbance. Here, in patients with this untreatable disease, we have underlined...

article

Sulfatide decreases the resistance to stress-induced apoptosis and increases P-selectin-mediated adhesion: a two-edged sword in breast cancer progression

Jaroslaw Suchanski, Jedrzej Grzegrzolka, Tomasz Owczarek, Pawel Pasikowski, more

Breast Cancer Research > 2018 > 20 > 1 > 1-18

Background We have previously shown that galactosylceramide (GalCer) affects the tumourigenic and metastatic properties of breast cancer cells by acting as an anti-apoptotic molecule. Since GalCer is a precursor molecule in the synthesis of sulfatides, the present study was aimed to define the role of sulfatides in apoptosis and breast cancer progression. Methods Expression of GAL3ST1 in breast...

article

The expression of IL10RA in colorectal cancer and its correlation with the proliferation index and the clinical stage of the disease

Łukasz Zadka, Michał J. Kulus, Krzysztof Kurnol, Aleksandra Piotrowska, more

Cytokine > 2018 > 110 > C > 116-125

Despite the widely described role of IL10 in immune response regulation during carcinogenesis, there is no established model describing the role of its receptor. The aim of this study is to elucidate the relationship between the subunit alpha of IL10 receptor (IL10RA) in the pathogenesis of colorectal cancer (CRC).The study was conducted on archived paraffin blocks of 125 CRC patients, from which...

article

Bone marrow adipocytes in haematological malignancies

Ewa Frączak, Mateusz Olbromski, Aleksandra Piotrowska, Natalia Glatzel-Plucińska, more

Acta Histochemica > 2018 > 120 > 1 > 22-27

Bone marrow adipocytes (BMAs) derived from mesenchymal stem cells (MSC) are an active and significant element of the bone marrow microenvironment. They are involved in metabolic functions, complex interactions with other stromal cells, and in the development and progression of tumours. Currently, there is little data regarding the role of BMAs in haematological malignancies. Due to this, we have attempted...

article

Toxicity evaluation of selected ammonium-based ionic liquid forms with MCPP and dicamba moieties on Pseudomonas putida

Aleksandra Piotrowska, Anna Syguda, Bogdan Wyrwas, Łukasz Chrzanowski, more

Chemosphere > 2017 > 167 > C > 114-119

Combination of the hydrophilic herbicidal anion with hydrophobic, antimicrobial ammonium cation allows to obtain compounds in ionic liquid form with better properties then conventional herbicides. Both cation and anion can be modified by selection of herbicide and the length of alkyl chains in cation structure. However the knowledge of their potential toxic effects are still limited. Furthermore,...

article

Toxicity of synthetic herbicides containing 2,4-D and MCPA moieties towards Pseudomonas putida mt-2 and its response at the level of membrane fatty acid composition

Aleksandra Piotrowska, Anna Syguda, Łukasz Chrzanowski, Hermann J. Heipieper

Chemosphere > 2016 > 144 > C > 107-112

One of the attempts to create more effective herbicidal compounds includes the use of ionic liquids. Herbicidal ionic liquids have more effective biological activity, they are less volatile, more thermally stable, and exhibit superior efficiency in comparison to typically employed herbicides, allowing the reduction of the herbicide dose applied per hectare. However, studies on the environmental toxicity...

article

Cellulose-based carbon—A potential anode material for lithium-ion battery

Krzysztof Kierzek, Aleksandra Piotrowska, Jacek Machnikowski

Journal of Physics and Chemistry of Solids > 2015 > 86 > C > 215-222

A series of hard carbons was produced by the carbonization of microcrystalline cellulose powder in the temperature range of 950–1100°C. The properties of the carbons were characterized using elemental analysis, X-ray diffraction and N₂ and CO₂ adsorption. The effect of heat-treatment temperature (HTT), pyrolytic carbon (PC) coating and discharging mode on the lithium insertion/deinsertion behavior...

article

Nogo‐B expression, in arterial intima, is impeded in the early stages of atherosclerosis in humans

Katarzyna Drożdż, Irmina Grzegorek, Magdalena Chmielewska, Agnieszka Gomułkiewicz, more

APMIS > 122 > 9 > 742 - 749

Nogo‐B (Reticulon 4B) is considered to be a novel vascular marker, which may have a protective role in injury‐induced neointima formation and atherosclerosis. Nogo A/B is found to be crucial for monocyte/macrophage recruitment in acute inflammation and it is expressed in CD68 + macrophages. We hypothesize that macrophage infiltration in atherosclerosis is not dependent on Nogo‐B expression in arterial...

article

Properties and lithium insertion behavior of hard carbons produced by pyrolysis of various polymers at 1000°C

Aleksandra Piotrowska, Krzysztof Kierzek, Piotr Rutkowski, Jacek Machnikowski

Journal of Analytical and Applied Pyrolysis > 2013 > 102 > Complete > 1-6

A series of hard carbons were produced by pyrolysis at 1000°C of various easily available polymers and oxidized pitch. Elemental and X-ray diffraction analyses do not reveal any essential differences in the chemical composition and structural ordering amongst the resultant carbons, except for polyacrylonitrile-based one. In contrast, N ₂ and CO ₂ adsorption examinations, show variety...

article

Metallothionein 1F and 2A overexpression predicts poor outcome of non-small cell lung cancer patients

Bozena Werynska, Bartosz Pula, Beata Muszczynska-Bernhard, Agnieszka Gomulkiewicz, more

Experimental and Molecular Pathology > 2013 > 94 > 1 > 301-308

Metallothioneins (MT) are intracellular, low molecular weight proteins (6–7kDa) involved in binding of metal ions, scavenging of free radicals, cell proliferation and apoptosis and resistance to certain chemotherapeutics. Four basic families of MT proteins are distinguished: MT-I, MT-II, MT-III, MT-IV, within each of them different isoforms occur. The study aimed at examining the expression level...

article

Corrigendum to “Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber–CA3 pathway” [Molecular and Cellular Neuroscience 50/2 (2012) 147–159]

Grzegorz Wiera, Tomasz Wójtowicz, Katarzyna Lebida, Aleksandra Piotrowska, more

Molecular and Cellular Neuroscience > 2013 > 52 > Complete > 181-182

article

Bioavailability of hydrocarbons to bacterial consortia during Triton X-100 mediated biodegradation in aqueous media

Daria Pęziak, Aleksandra Piotrowska, Roman Marecik, Piotr Lisiecki, more

Acta Biochimica Polonica > 2013 > 60 > 4 > 789-793

The aim of our study was to investigate the effect of Triton X-100 on the biodegradation efficiency of hexadecane and phenanthrene carried out by two bacterial consortia. It was established that the tested consortia were not able to directly uptake compounds closed in micelles. It was observed that in micellar systems the nonionic synthetic surfactant was preferentially degraded (the degradation efficiency...

article

Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber — CA3 pathway

Grzegorz Wiera, Tomasz Wójtowicz, Katarzyna Lebida, Aleksandra Piotrowska, more

Molecular and Cellular Neuroscience > 2012 > 50 > 2 > 147-159

Matrix Metalloproteinases (MMPs) are a family of endopeptidases known to process extracellular proteins. In the last decade, studies carried out mainly on the Schaffer collateral — CA1 hippocampal projection have provided solid evidence that MMPs regulate synaptic plasticity and learning. Recently, our group has shown that MMP blockade disrupts LTP maintenance also in the mossy fiber-CA3 (mf-CA3)...

article

Angiotensin II Type 1 Receptor (AT-1R) Expression Correlates with VEGF-A and VEGF-D Expression in Invasive Ductal Breast Cancer

Aleksandra Jethon, Bartosz Pula, Aleksandra Piotrowska, Andrzej Wojnar, more

Pathology & Oncology Research > 2012 > 18 > 4 > 867-873

Recent studies point to the involvement of angiotensin II (Ang II) receptor type 1 (AT-1R) on processes of metastasing, stimulation of invasiveness and angiogenesis in tumours. In this study, the correlation between intensity of AT-1R expression and expression of lymph- and angiogenesis markers in invasive ductal breast cancers (IDC) was examined. Immunohistochemical studies (IHC) were performed on...

article

Podoplanin expression by cancer‐associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma

Bartosz Pula, Aleksandra Jethon, Aleksandra Piotrowska, Agnieszka Gomulkiewicz, more

Histopathology > 59 > 6 > 1249 - 1260

Pula B, Jethon A, Piotrowska A, Gomulkiewicz A, Owczarek T, Calik J, Wojnar A, Witkiewicz W, Rys J, Ugorski M, Dziegiel P & Podhorska‐Okolow M  (2011) Histopathology 59, 1249–1260  Podoplanin expression by cancer‐associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma Aims: It has recently been shown that podoplanin, a mucin‐type glycoprotein, is expressed by cancer cells...

article

Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures

Jan Magdalan, Aleksandra Piotrowska, Agnieszka GomuŁkiewicz, Tomasz Sozański, more

Experimental and Toxicologic Pathology > 2011 > 63 > 4 > 311-315

High mortality rate in Amanita phalloides (death cap) intoxications is a result of the acute liver failure following hepatocyte damage due to hepatocellular uptake of amatoxins. α-Amanitin (α-AMA), the major amatoxin, blocks a RNA polymerase II, which results in inhibition of transcription of DNA and protein synthesis processes and leads to hepatocyte death. α-AMA is also a strong apoptosis inductor...

article

Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, more

Experimental and Toxicologic Pathology > 2010 > 62 > 4 > 367-373

Fatalities due to mushroom poisonings are increasing worldwide, with high mortality rate resulting from ingestion of amanitin-producing species. Intoxications caused by amanitin-containing mushrooms represent an unresolved problem in clinical toxicology since no specific and fully efficient antidote is available. The objective of this study was a comparative evaluation of benzylpenicillin (BPCN),...

article

Comparative antidotal efficacy of benzylpenicillin, ceftazidime and rifamycin in cultured human hepatocytes intoxicated with α-amanitin

Jan Magdalan, Alina Ostrowska, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, more

Archives of Toxicology > 2009 > 83 > 12 > 1091-1096

The most often used antidote to treat poisoning caused by amanitin-containing mushrooms is benzylpenicillin (BPCN). However, a very few reports suggest that other antibiotics such as ceftazidime (CEFT) and rifamycin SV (RIFSV) show better antidote activity against amanitins than BPCN. Given this, there is an ongoing debate as which of three antidotes is optimal for treatment of such poisonings. In...

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INFONA - science communication portal

Search results for: Aleksandra Piotrowska

Association between grade brain tumors and the interleukin‐10 receptor subunit alpha based on surface‐enhanced Raman spectroscopy and multivariate analysis

Long‐term stiripentol administration, an anticonvulsant drug, does not impair sperm parameters in rats

Immunohistochemical and ultrastructural analysis of sporadic inclusion body myositis: a case series

Sulfatide decreases the resistance to stress-induced apoptosis and increases P-selectin-mediated adhesion: a two-edged sword in breast cancer progression

The expression of IL10RA in colorectal cancer and its correlation with the proliferation index and the clinical stage of the disease

Bone marrow adipocytes in haematological malignancies

Toxicity evaluation of selected ammonium-based ionic liquid forms with MCPP and dicamba moieties on Pseudomonas putida

Toxicity of synthetic herbicides containing 2,4-D and MCPA moieties towards Pseudomonas putida mt-2 and its response at the level of membrane fatty acid composition

Cellulose-based carbon—A potential anode material for lithium-ion battery

Nogo‐B expression, in arterial intima, is impeded in the early stages of atherosclerosis in humans

Properties and lithium insertion behavior of hard carbons produced by pyrolysis of various polymers at 1000°C

Metallothionein 1F and 2A overexpression predicts poor outcome of non-small cell lung cancer patients

Corrigendum to “Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber–CA3 pathway” [Molecular and Cellular Neuroscience 50/2 (2012) 147–159]

Bioavailability of hydrocarbons to bacterial consortia during Triton X-100 mediated biodegradation in aqueous media

Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber — CA3 pathway

Angiotensin II Type 1 Receptor (AT-1R) Expression Correlates with VEGF-A and VEGF-D Expression in Invasive Ductal Breast Cancer

Podoplanin expression by cancer‐associated fibroblasts predicts poor outcome in invasive ductal breast carcinoma

Benzylpenicyllin and acetylcysteine protection from α-amanitin-induced apoptosis in human hepatocyte cultures

Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with α-amanitin

Comparative antidotal efficacy of benzylpenicillin, ceftazidime and rifamycin in cultured human hepatocytes intoxicated with α-amanitin

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