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In the early 1900s, medical practitioners recognized fasting as an effective method for controlling seizures (1,2). The mechanism by which fasting suppressed seizures was initially explained as an alleviation of “intestinal intoxication,” which in turn was thought to be the cause of epilepsy (1).
In recent years, our laboratory has been using the kindling model in a search for new drugs effective against intractable epilepsy. In this chapter, I would like to discuss (1) intractable epilepsy; (2) the limbic kindling model and how it should be used in pharmacological studies related to complex partial seizures; (3) our approach to drug discovery; (4) our experiments with deoxycorticosterone...
Summary The ketogenic diet is a high-fat, low-carbohydrate diet used to treat drug-resistant seizures, especially in children. A number of possible mechanisms of action have been proposed to explain the anticonvulsant effects of the diet. Four of these hypothetical mechanisms are discussed in the present article: the pH hypothesis, the metabolic hypotheses, the amino acid hypothesis, and the ketone...
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