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Background: Rfx winged‐helix transcription factors, best known as key regulators of core ciliogenesis, also play ciliogenesis‐independent roles during neural development. Mammalian Rfx4 controls neural tube morphogenesis via both mechanisms. Results: We set out to identify conserved aspects of rfx4 gene function during vertebrate development and to establish a new genetic model in which to analyze...
The vertebrate retina develops in close proximity to the forebrain and neural crest-derived cartilages of the face and jaw. Coloboma, a congenital eye malformation, is associated with aberrant forebrain development (holoprosencephaly) and with craniofacial defects (frontonasal dysplasia) in humans, suggesting a critical role for cross-lineage interactions during retinal morphogenesis. ZIC2, a zinc-finger...
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