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Nodal proteins are diffusible morphogens that drive pattern formation via short‐range feedback activation coupled to long‐range Lefty‐mediated inhibition. In the sea urchin embryo, specification of the secondary (oral‐aboral) axis occurs via zygotic expression of nodal, which is localized to the prospective oral ectoderm at early blastula stage. In mid‐blastula stage embryos treated with low micromolar...
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