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The structure of the chemically synthesized C-terminal region of the human agouti related protein (AGRP) was determined by 2D 1 H NMR. Referred to as minimized agouti related protein, MARP is a 46 residue polypeptide containing 10 Cys residues involved in five disulfide bonds that retains the biological activity of full length AGRP. AGRP is a mammalian signaling molecule, involved in weight...