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Acne vulgaris is caused and aggravated by a number of different factors, among which colonisation of sebaceous glands with Propionibacterium acnes appears to play a key role in the etiology of the disease. Prop. acnes has been shown to produce and secrete a number of lipolytic enzymes, causing enzymatic degradation of sebum and production of pro-inflammatory metabolites from polyunsaturated fatty...
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