Multicomponent DNA vaccines were used to elicit immune responses, which can impact viral challenge in three separate rhesus macaque models. Eight rhesus macaques were immunized with DNA vaccines for HIV env/rev and SIV gag/pol and were challenged intravenously with 10 animal infective doses (AID 50 ) of cell-free SHIV IIIB. Three of eight immunized rhesus macaques were protected, exhibiting...
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