Search results for: Nikola Kozhuharov

Items from 1 to 19 out of 19 results

article

Comprehensive vasodilatation in women with acute heart failure: Novel insights from the GALACTIC randomized controlled trial

Desiree Wussler, Maria Belkin, Micha T. Maeder, Joan Walter, more

European Journal of Heart Failure > 25 > 12 > 2218 - 2229

Aims Sex‐specific differences in acute heart failure (AHF) are both relevant and underappreciated. Therefore, it is crucial to evaluate the risk/benefit ratio and the implementation of novel AHF therapies in women and men separately. Methods and results We performed a pre‐defined sex‐specific analysis in AHF patients randomized to a strategy of early intensive and sustained vasodilatation versus...

article

Quantifying inflammation using interleukin‐6 for improved phenotyping and risk stratification in acute heart failure

Eleni Michou, Desiree Wussler, Maria Belkin, Cornelia Simmen, more

European Journal of Heart Failure > 25 > 2 > 174 - 184

Aims Systemic inflammation may be central in the pathophysiology of acute heart failure (AHF). We aimed to assess the possible role of systemic inflammation in the pathophysiology, phenotyping, and risk stratification of patients with AHF. Methods and results Using a novel Interleukin‐6 immunoassay with unprecedented sensitivity (limit of detection 0.01 ng/L), we quantified systemic inflammation...

article

Clinical effect of obesity on N‐terminal pro‐B‐type natriuretic peptide cut‐off concentrations for the diagnosis of acute heart failure

Nikola Kozhuharov, Jasmin Martin, Desiree Wussler, Pedro Lopez‐Ayala, more

European Journal of Heart Failure > 24 > 9 > 1545 - 1554

Aims Obese patients have lower natriuretic peptide concentrations. We hypothesized that adjusting the concentration of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) for obesity could further increase its clinical utility in the early diagnosis of acute heart failure (AHF). Methods and results This hypothesis was tested in a prospective diagnostic study enrolling unselected patients presenting...

article

Cardiac myosin‐binding protein C in the diagnosis and risk stratification of acute heart failure

Nikola Kozhuharov, Desiree Wussler, Thomas Kaier, Ivo Strebel, more

European Journal of Heart Failure > 23 > 5 > 716 - 725

Aims Cardiac myosin‐binding protein C (cMyC) seems to be even more sensitive in the quantification of cardiomyocyte injury vs. high‐sensitivity cardiac troponin, and may therefore have diagnostic and prognostic utility. Methods and results In a prospective multicentre diagnostic study, cMyC, high‐sensitivity cardiac troponin T (hs‐cTnT), and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP)...

article

Man vs machine: Performance of manual vs automated electrocardiogram analysis for predicting the chamber of origin of idiopathic ventricular arrhythmia

Babken Asatryan, Ramin Ebrahimi, Ivo Strebel, Peter M. Dam, more

Journal of Cardiovascular Electrophysiology > 31 > 2 > 410 - 416

Background Radiofrequency catheter ablation of idiopathic ventricular arrhythmias (VAs) is performed to eliminate symptoms and to prevent or reverse arrhythmia‐induced cardiomyopathy. Preprocedural prediction of the chamber of VA origin is critical for patient counseling, procedure planning, and guidance of invasive mapping. Objective We aimed to assess the performance of manual expert versus automated...

article

Proenkephalin and prognosis in heart failure with preserved ejection fraction: a GREAT network study

Prathap Kanagala, Iain B. Squire, Donald J. L. Jones, Thong Huy Cao, more

Zeitschrift für Kardiologie > 2019 > 108 > 8 > 940-949

Background Proenkephalin (PENK), a stable endogenous opioid biomarker related to renal function, has prognostic utility in acute and chronic heart failure. We investigated the prognostic utility of PENK in heart failure with preserved ejection fraction (HFpEF), and its relationship to renal function, Body Mass Index (BMI), and imaging measures of diastolic dysfunction. Methods In this multicentre...

article

Heart Failure

Sebastian L. Dietsche, Tobias Breidthardt, Nikola Kozhuharov, Christian E. Mueller

Journal of the American College of Cardiology > 2018 > 72 > 10 > 1180

article

Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction

Raphael Twerenbold, Johannes Tobias Neumann, Nils Arne Sörensen, Francisco Ojeda, more

Journal of the American College of Cardiology > 2018 > 72 > 6 > 620-632

The safety of the European Society of Cardiology (ESC) 0/1-h algorithm for rapid rule-out and rule-in of non–ST-segment elevation myocardial infarction (NSTEMI) using high-sensitivity cardiac troponin (hs-cTn) has been questioned.This study aimed to validate the diagnostic performance of the 0/1-h algorithm in a large multicenter study.The authors prospectively enrolled unselected patients in 6 countries...

article

How accurate is clinical assessment of neck veins in the estimation of central venous pressure in acute heart failure? Insights from a prospective study

Tobias Breidthardt, Zoraida Moreno‐Weidmann, Heiko Uthoff, Zaid Sabti, more

European Journal of Heart Failure > 20 > 7 > 1160 - 1162

article

Automatically computed ECG algorithm for the quantification of myocardial scar and the prediction of mortality

Patrick Badertscher, Ivo Strebel, Ursina Honegger, Nicolas Schaerli, more

Clinical Research in Cardiology > 2018 > 107 > 9 > 824-835

Background Myocardial scar is associated with adverse cardiac outcomes. The Selvester QRS-score was developed to estimate myocardial scar from the 12-lead ECG, but its manual calculation is difficult. An automatically computed QRS-score would allow identification of patients with myocardial scar and an increased risk of mortality. Objectives To assess the diagnostic and prognostic value of the automatically...

article

Diagnostic and prognostic value of cystatin C in acute heart failure

Tobias Breidthardt, Zaid Sabti, Ronny Ziller, Frank Rassouli, more

Clinical Biochemistry > 2017 > 50 > 18 > 1007-1013

The accurate early diagnosis of acute kidney injury (AKI) in patients with acute heart failure (AHF) is an unmet clinical need. Cystatin C might improve the early detection of AKI.207 patients presenting to the emergency department with AHF were enrolled. Cystatin C was measured in plasma in a blinded fashion at presentation and serially thereafter. The potential of Cystatin C levels to predict AKI...

article

Effect of Definition on Incidence and Prognosis of Type 2 Myocardial Infarction

Thomas Nestelberger, Jasper Boeddinghaus, Patrick Badertscher, Raphael Twerenbold, more

Journal of the American College of Cardiology > 2017 > 70 > 13 > 1558-1568

Uncertainties regarding the most appropriate definition and treatment of type 2 myocardial infarction (T2MI) due to supply-demand mismatch have contributed to inconsistent adoption in clinical practice.This study sought a better understanding of the effect of the definition of T2MI on its incidence, treatment, and event-related mortality, thereby addressing an important unmet clinical need.The final...

article

Diagnostic value of ST-segment deviations during cardiac exercise stress testing: Systematic comparison of different ECG leads and time-points

Christian Puelacher, Max Wagener, Roger Abächerli, Ursina Honegger, more

International Journal of Cardiology > 2017 > 238 > C > 166-172

Exercise ECG stress testing is the most widely available method for evaluation of patients with suspected myocardial ischemia. Its major limitation is the relatively poor accuracy of ST-segment changes regarding ischemia detection. Little is known about the optimal method to assess ST-deviations.A total of 1558 consecutive patients undergoing bicycle exercise stress myocardial perfusion imaging (MPI)...

article

Diagnostic and prognostic values of the V-index, a novel ECG marker quantifying spatial heterogeneity of ventricular repolarization, in patients with symptoms suggestive of non-ST-elevation myocardial infarction

Roger Abächerli, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, more

International Journal of Cardiology > 2017 > 236 > C > 23-29

The V-index is an ECG marker quantifying spatial heterogeneity of ventricular repolarization. We prospectively assessed the diagnostic and prognostic values of the V-index in patients with suspected non-ST-elevation myocardial infarction (NSTEMI).We prospectively enrolled 497 patients presenting with suspected NSTEMI to the emergency department (ED). Digital 12-lead ECGs of five-minute duration were...

article

Impact of haemoconcentration during acute heart failure therapy on mortality and its relationship with worsening renal function

Tobias Breidthardt, Zoraida Moreno Weidmann, Raphael Twerenbold, Claudine Gantenbein, more

European Journal of Heart Failure > 19 > 2 > 226 - 236

Aims Treatment goals in acute heart failure (AHF) are poorly defined. We aimed to characterize further the impact of in‐hospital haemoconcentration and worsening renal function (WRF) on short‐ and long‐term mortality. Methods and results Haematocrit, haemoglobin, total protein, serum creatinine, and albumin levels were measured serially in 1019 prospectively enrolled AHF patients. Haemoconcentration...

article

Early diagnosis of acute myocardial infarction in patients with mild elevations of cardiac troponin

Jasper Boeddinghaus, Tobias Reichlin, Thomas Nestelberger, Raphael Twerenbold, more

Clinical Research in Cardiology > 2017 > 106 > 6 > 457-467

Background The early diagnosis of acute myocardial infarction (AMI) in patients with mild elevations of high-sensitivity cardiac troponin (hs-cTn) is a challenge. It is unclear whether copeptin, a marker of endogenous stress, or 1h-hs-cTn changes are better suited to address this important unmet clinical need. Methods We prospectively enrolled patients presenting with symptoms suggestive of AMI...

article

Proenkephalin, Renal Dysfunction, and Prognosis in Patients With Acute Heart Failure

Leong L. Ng, Iain B. Squire, Donald J.L. Jones, Thong Huy Cao, more

Journal of the American College of Cardiology > 2017 > 69 > 1 > 56-69

Proenkephalin A (PENK) and its receptors are widely distributed. Enkephalins are cardiodepressive and difficult to measure directly. PENK is a stable surrogate analyte of labile enkephalins that is correlated inversely with renal function. Cardiorenal syndrome is common in acute heart failure (HF) and portends poor prognosis.This study assessed the prognostic value of PENK in acute HF, by identifying...

article

Gender-specific uncertainties in the diagnosis of acute coronary syndrome

Petra Hillinger, Raphael Twerenbold, Karin Wildi, Maria Rubini Gimenez, more

Clinical Research in Cardiology > 2017 > 106 > 1 > 28-37

Background It is unknown whether higher rates of delayed diagnosis and misdiagnosis of acute coronary syndrome (ACS) in women might have contributed to the poorer outcome of women. Methods In a prospective diagnostic multicenter study, we recruited patients presenting to the emergency department (ED) with any kind of chest discomfort/chest pain with onset or peak within the last 12 h. We quantified...

article

Characterization of the observe zone of the ESC 2015 high-sensitivity cardiac troponin 0h/1h-algorithm for the early diagnosis of acute myocardial infarction

Thomas Nestelberger, Karin Wildi, Jasper Boeddinghaus, Raphael Twerenbold, more

International Journal of Cardiology > 2016 > 207 > C > 238-245

The novel high-sensitivity cardiac troponin (hs-cTn) 0h/1h-algorithm substantially improves the early triage of patient's assigned “rule-out” or “rule-in” of acute myocardial infarction (AMI), while diagnostic uncertainty remains in that 25–30% of patients assigned to “observe”. We aimed to better characterize these patients.In a prospective multicenter diagnostic study, we applied the hs-cTnT 0h/1h-algorithm...

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Keywords

ACUTE HEART FAILURE (6)
DIAGNOSIS (3)
MORTALITY (3)
ACUTE KIDNEY INJURY (2)
ACUTE MYOCARDIAL INFARCTION (2)
ECG (2)
HEART FAILURE (2)
HIGH-SENSITIVITY CARDIAC TROPONIN (2)
OPIOIDS (2)
ACUTE CORONARY SYNDROME (1)
B-TYPE NATRIURETIC PEPTIDE (1)
B-TYPE NATRIURETIC PEPTIDE (1)
BICYCLE ERGOMETRY TEST (1)
CARDIAC IMAGING (1)
CARDIAC MYOSIN‐BINDING PROTEIN C (1)
CATHETER ABLATION (1)
COMPUTATIONAL PREDICTION (1)
COPEPTIN (1)
CUT‐OFFS (1)
CYSTATIN C (1)
DELAYED DIAGNOSIS (1)
DIAGNOSIS OF AMI (1)
DIAGNOSIS OF MYOCARDIAL INFARCTION (1)
DIAGNOSTIC ALGORITHM (1)
DIAGNOSTIC ALGORITHMS (1)
DIAGNOSTIC UNCERTAINTY (1)
ELECTROCARDIOGRAPHY (1)
GENDER (1)
HAEMOCONCENTRATION (1)
IDIOPATHIC VENTRICULAR ARRHYTHMIA (1)
INTERLEUKIN‐6 (1)
MESH HEADING: SENSITIVITY AND SPECIFICITY (1)
MYOCARDIAL INFARCTION (1)
MYOCARDIAL PERFUSION IMAGING (1)
MYOCARDIAL SCAR (1)
NATRIURETIC PEPTIDES (1)
NET RECLASSIFICATION IMPROVEMENT (1)
OBESITY (1)
PHARMACOTHERAPY (1)
PREDICTION (1)
PREMATURE VENTRICULAR COMPLEX (1)
PRESERVED EJECTION FRACTION (1)
PROENKEPHALIN (1)
PROGNOSIS (1)
RENAL FUNCTION (1)
RULE-IN (1)
RULE-OUT (1)
SELVESTER QRS-SCORE (1)
SEX DIFFERENCES (1)
SEX‐SPECIFIC THERAPY APPROACH (1)
ST-SEGMENT (1)
SYSTEMIC INFLAMMATION (1)
THERAPY GUIDANCE (1)
TROPONIN (1)
TYPE 2 MYOCARDIAL INFARCTION (1)
WORSENING RENAL FUNCTION (1)
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Search results for: Nikola Kozhuharov

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