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To analyse initial tobacco-related cellular alterations in the upper aerodigestive tract, we investigated the proliferation state in paraffin embedded samples of tumour-adjacent histologically normal mucosa from head and neck squamous cell carcinoma (HNSCC) patients and normal buccal mucosa from healthy individuals. The proliferation index (PI) was assessed by indirect immunohistochemical staining...
To analyse initial tobacco-related cellular alterations in the upper aerodigestive tract, we investigated the proliferation state in paraffin embedded samples of tumour-adjacent histologically normal mucosa from head and neck squamous cell carcinoma (HNSCC) patients and normal buccal mucosa from healthy individuals. The proliferation index (PI) was assessed by indirect immunohistochemical staining...
In 86 primary breast cancer patients, we evaluated the prognostic significance of PTK (n = 81), ER (n = 83), PR (n = 83), and the mitotic activity index (n = 60). We compared the prognostic significance of these variables with classical prognosticators like; menopausal status, T-stage, N-stage, and histological grading according to Bloom and Richardson.Protein tyrosin kinases (PTK) are enzymes which...
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