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Background: Tropomodulins are actin‐capping proteins that regulate the stability of the slow‐growing, minus‐ends of actin filaments. The C. elegans tropomodulin homolog, UNC‐94, has sequence and functional similarity to vertebrate tropomodulins. We investigated the role of UNC‐94 in C. elegans intestinal morphogenesis. Results: In the embryonic C. elegans intestine, UNC‐94 localizes to the terminal...
In multicellular organisms, cell-cell junctions are involved in many aspects of tissue morphogenesis. α-catenin links the cadherin-catenin complex (CCC) to the actin cytoskeleton, stabilizing cadherin-dependent adhesions.To identify modulators of cadherin-based cell adhesion, we conducted a genome-wide RNAi screen in C. elegans and uncovered MAGI-1, a highly conserved protein scaffold. Loss of magi-1...
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