Search results for: Johannes Schwarz

Items from 1 to 20 out of 58 results

article

Dyskinesia in multiple system atrophy and progressive supranuclear palsy

Wolfgang H. Jost, Paul Lingor, Lars Tönges, Johannes Schwarz, more

Journal of Neural Transmission > 2019 > 126 > 7 > 925-932

In the differential diagnosis of Parkinson syndromes, the response to l-Dopa is an essential criterion for the diagnosis of idiopathic Parkinson’s syndrome (IPS), and the presence of l-Dopa-induced dyskinesia (LID) is considered a supportive criterion. This implies that in the presence of LID an atypical Parkinson-syndrome (APS) is unlikely. However, dyskinesia, and in particular LID, can also be...

article

Status Epilepticus After Subthalamic Deep Brain Stimulation Surgery in a Patient with Parkinson's Disease

Angela Jochim, Jens Gempt, Marcus Deschauer, Kathleen Bernkopf, more

World Neurosurgery > 2016 > 96 > C > 614.e1-614.e6

Subthalamic deep brain stimulation (DBS) is a well-established treatment for patients with Parkinson's disease who suffer from severe motor fluctuations. The most common surgery-related complications are temporary confusion, bleedings, infections, and seizures. Seizures have been described to occur mainly around the time of the implantation of electrodes and, at present, the best established risk...

article

A Placebo‐Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa‐Induced Dyskinesia

Claudia Trenkwalder, Daniela Berg, Olivier Rascol, Karla Eggert, more

Movement Disorders > 31 > 7 > 1049 - 1054

BackgroundThis phase 2 randomized, double‐blind, placebo‐controlled study evaluated the efficacy and safety of the nicotinic acetylcholine receptor α7 agonist AQW051 in patients with Parkinson's disease and levodopa‐induced dyskinesia. MethodsPatients with idiopathic Parkinson's disease and moderate to severe levodopa‐induced dyskinesia were randomized to AQW051 10 mg (n = 24), AQW051 50 mg (n = 24),...

chapter

Diagnostic Test for Neuroacanthocytosis: Quantitative Measurement of Red Blood Cell Morphology

Alexander Storch, Johannes Schwarz

Neuroacanthocytosis Syndromes > Clinical Context > 71-77

Acanthocytosis is defined as an increased amount of abnormally shaped red blood cells with multiple spicules, which are irregular in shape, orientation and distribution. These morphological changes occur normally because of ultrastructural abnormalities of the erythrocyte membrane due to lipid or membrane skeleton alterations. Since genetic analyses and/or specific laboratory tests are available only...

article

Neural stem cell culture model for LRRK2 function determines regulation of dopaminergic and microtubule-associated genes

Anne K. Meyer, Charanya Sampathkumar, Lars Fransecky, Martina Maisel, more

Basal Ganglia > 2015 > 5 > 4 > 71-76

Leucine-rich repeat kinase 2 (Lrrk2) is a Parkinson’s disease (PD)-related protein involved in sporadic and familial cases of the disease. Lrrk2 is a kinase and may be involved in intracellular signaling pathways. We established a neural stem cell (NSC)-based model system for Lrrk2-associated PD. We investigated its physiological and pathophysiological expression in human and mouse brain and NSCs...

article

The relevance of imaging for the diagnosis of Parkinson's disease

Johannes Schwarz, Heinz Reichmann, Peter Urban, Tobias Warnecke, more

Basal Ganglia > 2014 > 4 > 1 > 25-27

Multiple modalities for imaging the brain have become available for patients with neurodegenerative disorders. Without doubt, functional imaging has improved our understanding of the underlying pathophysiology, led to increased sensitivity and specificity of the diagnosis of idiopathic Parkinson's disease (PD). Despite these achievements, however the diagnosis of PD is still primarily based on clinical...

article

Report on the 32th Annual Meeting of the Working Group “Beneficial Arthropods and Entomopathogenic Nematodes”

Annette Herz, Ralf-Udo Ehlers, Johannes A Jehle, Eva Fritsch, more

Journal of Plant Diseases and Protection > 2014 > 121 > 2 > 96-104

article

Lack of vascular endothelial growth factor receptor-2/Flk1 signaling does not affect substantia nigra development

Andreas Hermann, Kai F. Loewenbrück, Änne Boldt, Christiane Fiedler, more

Neuroscience Letters > 2013 > 553 > Complete > 142-147

Oxygen tension is critical for proliferation of human and murine midbrain-derived neural precursor cells (mNPCs). Lack of hypoxia-inducible factor-1α (HIF1α) impairs midbrain dopaminergic neurogenesis which could be rescued by vascular endothelial growth factor (VEGF) via VEGFR-2 signaling. Here, we conditionally inactivated the VEGFR-2, encoded by the fetal liver kinase 1 (Flk1) gene, in murine NPCs...

article

Reduced LRRK2-positive neurons in the striatum of Parkinson’s disease patients hypothesize a retrograde disease mechanism?

Andreas Hermann, Camelia Monoranu, Johannes Schwarz, Susanne Petri, more

Basal Ganglia > 2012 > 2 > 2 > 67-72

One major unsolved question in leucine-rich repeat kinase 2 (LRRK2)-mediated dopaminergic degeneration in Parkinson disease (PD) is the discrepancy between the preferentially diseased neuron type (dopamine neurons within substantia nigra) and the expression pattern of LRRK2 (highest expression within dopamine neuron target areas, striatum).We investigated LRRK2 mRNA and protein expression pattern...

article

Corrigendum to “Generation and genetic modification of 3D cultures of human dopaminergic neurons derived from neural progenitor cells” [Methods 56 (2012) 452–460]

Catarina Brito, Daniel Simão, Inês Costa, Rita Malpique, more

Methods > 2012 > 57 > 1 > 138

article

Generation and genetic modification of 3D cultures of human dopaminergic neurons derived from neural progenitor cells

Catarina Brito, Daniel Simão, Inês Costa, Rita Malpique, more

Methods > 2012 > 56 > 3 > 452-460

Central nervous system (CNS) disorders remain a formidable challenge for the development of efficient therapies. Cell and gene therapy approaches are promising alternatives that can have a tremendous impact by treating the causes of the disease rather than the symptoms, providing specific targeting and prolonged duration of action. Hampering translation of gene-based therapeutic treatments of neurodegenerative...

article

The 5-HT1A-receptor agonist flibanserin reduces drug-induced dyskinesia in RGS9-deficient mice

Karl Strecker, Michael Adamaszek, Sven Ohm, Florian Wegner, more

Journal of Neural Transmission > 2012 > 119 > 11 > 1351-1359

Drug-induced dyskinesia is a major complication of dopamine replacement therapy in advanced Parkinson’s disease consisting of dystonia, chorea and athetosis. Agonists at 5-HT1A-receptors attenuate levodopa-induced motor complications in non-human primates. Mice with increased dopamine D2 receptor (DRD2) signalling due to the lack of expression of the regulator of G-protein signalling 9 (RGS9) also...

article

Analysis of the yeast nucleoporin Nup188 reveals a conserved S-like structure with similarity to karyopherins

Dirk Flemming, Damien P. Devos, Johannes Schwarz, Stefan Amlacher, more

Journal of Structural Biology > 2012 > 177 > 1 > 99-105

Nuclear pore complexes (NPCs) embedded in the double nuclear membrane mediate the entire nucleocytoplasmic transport between the nucleus and cytoplasm. Each NPC is composed of about 30 different proteins (nucleoporins or Nups), which exist in multiple (8, 16 or 32) copies within the NPC scaffold. Recently, we have identified and characterized the large structural Nups, Nup188 and Nup192, from the...

article

Population trends of birds across the iron curtain: Brain matters

Jiří Reif, Katrin Böhning-Gaese, Martin Flade, Johannes Schwarz, more

Biological Conservation > 2011 > 144 > 10 > 2524-2533

One approach to assess human impact on species’ population dynamics is to correlate ecological traits of species with their long-term population trends. Yet, few studies investigated population trends in multiple regions that differ in human impact to reveal which traits explain population trends over larger geographic areas and which only regionally. We examined the relationship between various species...

article

Neuroprotective effects of the beta-catenin stabilization in an oxygen- and glucose-deprived human neural progenitor cell culture system

Marco Skardelly, Khaled Gaber, Johannes Schwarz, Javorina Milosevic

International Journal of Developmental Neuroscience > 2011 > 29 > 5 > 543-547

β-Catenin stabilization achieved either via GSK-3β specific inhibition or involving canonical Wnt signalling pathway, contributes to neuroprotection in an oxygen–glucose deprivation (4h OGD) in vitro hypoxia model performed on human cortical neural progenitor cells previously differentiated into neurons and glia. Neuroprotection mechanisms include both acquiring tolerance to injury throughout preconditioning...

article

Deep brain stimulation and general anesthesia

Maria Braun, Dirk Winkler, Markus Wehner, Thilo Busch, more

Basal Ganglia > 2011 > 1 > 2 > 79-82

To study the effect of general anesthesia during electrode placement on the clinical outcome of Deep brain stimulation of the subthalamic nucleus (DBS-STN).DBS-STN is an effective therapy in patients with advanced Parkinson’s disease. Both, activity of subcortical neurons and intraoperative clinical testing important to control exact electrode placement are potentially obscured by analgesic or sedative...

article

Zur Schadensverteilung des durch Spannungsriss korrosion geschädigten vergüteten Spannstahls bei Brückenbauwerken

Thomas Bauer, Michael Müller, Rüdiger Patz, Tobias Wilhelm, more

Bautechnik > 88 > 3 > 151 - 159

Die Aussagekraft der rechnerischen Untersuchung zur Abschätzung des Gefährdungspotentials infolge Spannungsrisskorrosion hängt entscheidend von den Annahmen zu Schädigungsverlauf und —verteilung des Spannstahls ab. Mit systematischer Untersuchung des aus einem Bauwerk entnommenen Spannstahls konnte festgestellt werden, dass die bisher angenommene Schadenskonzentration an einer Stelle, welche zum Ausfall...

article

Preserved serotonin transporter binding in de novo Parkinson’s disease: negative correlation with the dopamine transporter

Karl Strecker, Florian Wegner, Swen Hesse, Georg-Alexander Becker, more

Journal of Neurology > 2011 > 258 > 1 > 19-26

Recent imaging and neuropathological studies indicate reduced serotonin transporter (SERT) in advanced Parkinson’s disease (PD). However, data on SERT in early PD patients are sparse. Following the hypothesis that the serotonergic system is damaged early in PD, the aim of our study was to investigate SERT availability by means of PET imaging. Since the loss of dopaminergic neurons is the pathologic...

article

Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest HIF-1 and miR-124a as important regulators

Martina Maisel, Hans-Jörg Habisch, Loïc Royer, Alexander Herr, more

Experimental Cell Research > 2010 > 316 > 17 > 2760-2778

Tissue-specific stem cells, such as bone-marrow-derived human mesenchymal stem cells (hMSCs), are thought to be lineage restricted and therefore, could only be differentiated into cell types of the tissue of origin. Several recent studies however have suggested that these types of stem cells might be able to break barriers of germ layer commitment and differentiate in vitro into cells with neuroectodermal...

article

Translation of stem cell therapy for neurological diseases

Sigrid C. Schwarz, Johannes Schwarz

Translational Research > 2010 > 156 > 3 > 155-160

“Regenerative medicine” hopefully will provide novel therapies for diseases that remain without effective therapy. This development is also true for most neurodegenerative disorders including Alzheimer’s disease, Huntington’s disease, or Parkinson’s disease. Transplantation of new neurons to the brain has been performed in Parkinson’s disease and in Huntington’s disease. The restoration of dopaminergic...

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INFONA - science communication portal

Search results for: Johannes Schwarz

Dyskinesia in multiple system atrophy and progressive supranuclear palsy

Status Epilepticus After Subthalamic Deep Brain Stimulation Surgery in a Patient with Parkinson's Disease

A Placebo‐Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa‐Induced Dyskinesia

Diagnostic Test for Neuroacanthocytosis: Quantitative Measurement of Red Blood Cell Morphology

Neural stem cell culture model for LRRK2 function determines regulation of dopaminergic and microtubule-associated genes

The relevance of imaging for the diagnosis of Parkinson's disease

Report on the 32th Annual Meeting of the Working Group “Beneficial Arthropods and Entomopathogenic Nematodes”

Lack of vascular endothelial growth factor receptor-2/Flk1 signaling does not affect substantia nigra development

Reduced LRRK2-positive neurons in the striatum of Parkinson’s disease patients hypothesize a retrograde disease mechanism?

Corrigendum to “Generation and genetic modification of 3D cultures of human dopaminergic neurons derived from neural progenitor cells” [Methods 56 (2012) 452–460]

Generation and genetic modification of 3D cultures of human dopaminergic neurons derived from neural progenitor cells

The 5-HT1A-receptor agonist flibanserin reduces drug-induced dyskinesia in RGS9-deficient mice

Analysis of the yeast nucleoporin Nup188 reveals a conserved S-like structure with similarity to karyopherins

Population trends of birds across the iron curtain: Brain matters

Neuroprotective effects of the beta-catenin stabilization in an oxygen- and glucose-deprived human neural progenitor cell culture system

Deep brain stimulation and general anesthesia

Zur Schadensverteilung des durch Spannungsriss korrosion geschädigten vergüteten Spannstahls bei Brückenbauwerken

Preserved serotonin transporter binding in de novo Parkinson’s disease: negative correlation with the dopamine transporter

Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest HIF-1 and miR-124a as important regulators

Translation of stem cell therapy for neurological diseases

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