Search results for: Martin Bauer

Items from 1 to 20 out of 124 results

article

The effect of Tetrahydrocannabinol on optic nerve head blood flow in healthy subjects

Nikolaus Hommer, Martin Kallab, Stephan Szegedi, Stefan Puchner, more

Acta Ophthalmologica > 97 > S263 > n/a - n/a

Purpose There is ample evidence that optic nerve head blood flow (ONHBF) is impaired in patients with glaucoma. Tetrahydrocannabinol (THC) is used in the treatment for glaucoma in some countries for several years due to its intraocular pressure (IOP) lowering effect. Beside its IOP lowering potential, THC features neuroprotective effects and may improve ocular hemodynamics. The aim of the present...

article

Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography

Irene Hernández Lozano, Rudolf Karch, Martin Bauer, Matthias Blaickner, more

The AAPS Journal > 2019 > 21 > 4 > 1-14

Positron emission tomography (PET) imaging with radiolabeled drugs holds great promise to assess the influence of membrane transporters on hepatobiliary clearance of drugs. To exploit the full potential of PET, quantitative pharmacokinetic models are required. In this study, we evaluated the suitability of different compartment models to describe the hepatic disposition of [¹¹C]erlotinib as a small-molecule...

article

Axion-like particles at future colliders

Martin Bauer, Mathias Heiles, Matthias Neubert, Andrea Thamm

The European Physical Journal C > 2019 > 79 > 1 > 1-25

Axion-like particles (ALPs) are pseudo Nambu–Goldstone bosons of spontaneously broken global symmetries in high-energy extensions of the Standard Model (SM). This makes them a prime target for future experiments aiming to discover new physics which addresses some of the open questions of the SM. While future high-precision experiments can discover ALPs with masses well below the GeV scale, heavier...

article

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study

Sabine Westphal, Christian Stoppe, Matthias Gruenewald, Berthold Bein, more

BMC Cardiovascular Disorders > 2019 > 19 > 1 > 1-12

Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent...

article

Comparing curves in homogeneous spaces

Zhe Su, Eric Klassen, Martin Bauer

Differential Geometry and its Applications > 2018 > 60 > C > 9-32

Of concern is the study of the space of curves in homogeneous spaces. Motivated by applications in shape analysis we identify two curves if they only differ by their parametrization and/or a rigid motion. For curves in Euclidean space the Square-Root-Velocity-Function (SRVF) allows to define and efficiently compute a distance on this infinite dimensional quotient space. In this article we present...

article

Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats

Dorra Amor, Sébastien Goutal, Solène Marie, Fabien Caillé, more

EJNMMI Research > 2018 > 8 > 1 > 1-10

Background Erlotinib is an epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer. The wide inter-individual pharmacokinetic (PK) variability of erlotinib may impact treatment outcome and/or toxicity. Recent in vivo studies reported a nonlinear uptake transport of erlotinib into the liver, suggesting carrier-mediated system(s)...

article

Universal properties of pseudoscalar mediators in dark matter extensions of 2HDMs

Martin Bauer, Martin Klassen, Valentin Tenorth

Journal of High Energy Physics > 2018 > 2018 > 7 > 1-28

Abstract We discuss universal signals of consistent models of pseudoscalar mediators for collider searches for Dark Matter. Keeping only the degrees of freedom that can not be decoupled due to consistency conditions, we present a universality class of simplified models with pseudoscalar mediators and renormalizable couplings to Standard Model fields. We compute stability and perturbativity constraints,...

article

Hunting all the hidden photons

Martin Bauer, Patrick Foldenauer, Joerg Jaeckel

Journal of High Energy Physics > 2018 > 2018 > 7 > 1-47

Abstract We explore constraints on gauge bosons of a weakly coupled U(1)_{B − L}, U1Lμ−Le,U1Le−LτandU1Lμ−Lτ $$ \mathrm{U}{(1)}_{L_{\mu }-{L}_e},\kern0.5em \mathrm{U}{(1)}_{L_e-{L}_{\tau }}\kern0.5em \mathrm{and}\kern0.5em \mathrm{U}{(1)}_{L_{\mu }-{L}_{\tau }} $$. To do so we apply the full constraining power of experimental bounds derived for a hidden photon of a secluded U(1)_X and translate them...

article

Landscape complexity promotes hoverflies across different types of semi‐natural habitats in farmland

Jens Schirmel, Matthias Albrecht, Philipp‐Martin Bauer, Louis Sutter, more

Journal of Applied Ecology > 55 > 4 > 1747 - 1758

Semi‐natural habitats (SNH) provide essential resources for many organisms in agricultural landscapes and can increase biodiversity at the local and landscape scale. For the management of ecosystem services, it is crucial to understand how local characteristics of SNH and the surrounding landscape complexity affect beneficial species. We investigated this for hoverflies (Diptera: Syrphidae)—an...

article

Pharmacokinetics of the P-gp Inhibitor Tariquidar in Rats After Intravenous, Oral, and Intraperitoneal Administration

Peter Matzneller, Manuel Kussmann, Sabine Eberl, Alexandra Maier-Salamon, more

European Journal of Drug Metabolism and Pharmacokinetics > 2018 > 43 > 5 > 599-606

Background and objective P-glycoprotein (P-gp), a transmembrane transporter expressed at the blood–brain barrier, restricts the distribution of diverse central nervous system-targeted drugs from blood into brain, reducing their therapeutic efficacy. The third-generation P-gp inhibitor tariquidar (XR9576) was shown to enhance brain distribution of P-gp substrate drugs in humans. Oral bioavailability...

article

Longitudinal investigation of neuroinflammation and metabolite profiles in the APP_swe×PS1_Δe9 transgenic mouse model of Alzheimer's disease

Aisling Chaney, Martin Bauer, Daniela Bochicchio, Alison Smigova, more

Journal of Neurochemistry > 144 > 3 > 318 - 335

There is increasing evidence linking neuroinflammation to many neurological disorders including Alzheimer's disease (AD); however, its exact contribution to disease manifestation and/or progression is poorly understood. Therefore, there is a need to investigate neuroinflammation in both health and disease. Here, we investigate cognitive decline, neuroinflammatory and other pathophysiological changes...

article

Fractional Sobolev metrics on spaces of immersed curves

Martin Bauer, Martins Bruveris, Boris Kolev

Calculus of Variations and Partial Differential Equations > 2018 > 57 > 1 > 1-24

Motivated by applications in the field of shape analysis, we study reparametrization invariant, fractional order Sobolev-type metrics on the space of smooth regular curves $$\mathrm {Imm}(\mathrm {S}^{1},\mathbb {R}^d)$$ Imm(S1,Rd) and on its Sobolev completions $${\mathcal {I}}^{q}(\mathrm {S}^{1},{\mathbb {R}}^{d})$$ Iq(S1,Rd) . We prove local well-posedness of the geodesic equations both on the...

article

Collider probes of axion-like particles

Martin Bauer, Matthias Neubert, Andrea Thamm

Journal of High Energy Physics > 2017 > 2017 > 12 > 1-63

Abstract Axion-like particles (ALPs), which are gauge-singlets under the Standard Model (SM), appear in many well-motivated extensions of the SM. Describing the interactions of ALPs with SM fields by means of an effective Lagrangian, we discuss ALP decays into SM particles at one-loop order, including for the first time a calculation of the a → πππ decay rates for ALP masses below a few GeV. We argue...

article

Cytotoxic properties of lactate ester alkoxylates in relation to various EO/PO-alkoxylation degrees

Susann Fayyaz, Moung Sook Lee, Martin Bauer, Reinhard Kreiling

Toxicology Letters > 2017 > 280 > S1 > S279

article

Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[¹¹C]verapamil in elderly vs. young subjects

Martin Bauer, Beatrix Wulkersdorfer, Rudolf Karch, Cécile Philippe, more

British Journal of Clinical Pharmacology > 83 > 9 > 1991 - 1999

Aims The efflux transporter P‐glycoprotein (ABCB1) acts at the blood–brain barrier (BBB) to restrict the distribution of many different drugs from blood to the brain. Previous data suggest an age‐associated decrease in the expression and function of ABCB1 at the BBB. In the present study, we investigated the influence of age on the magnitude of an ABCB1‐mediated drug–drug interaction (DDI) at the...

article

On geodesic completeness for Riemannian metrics on smooth probability densities

Martin Bauer, Sarang Joshi, Klas Modin

Calculus of Variations and Partial Differential Equations > 2017 > 56 > 4 > 1-18

The geometric approach to optimal transport and information theory has triggered the interpretation of probability densities as an infinite-dimensional Riemannian manifold. The most studied Riemannian structures are the Otto metric, yielding the $$L^2$$ L 2 -Wasserstein distance of optimal mass transport, and the Fisher–Rao metric, predominant in the theory of information geometry. On the...

chapter

The Square Root Velocity Framework for Curves in a Homogeneous Space

Zhe Su, Eric Klassen, Martin Bauer

2017 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW) > 680 - 689

2017 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)

In this paper we study the shape space of curves with values in a homogeneous space M = G/K, where G is a Lie group and K is a compact Lie subgroup. We generalize the square root velocity framework to obtain a reparametrization invariant metric on the space of curves in M. By identifying curves in M with their horizontal lifts in G, geodesics then can be computed. We can also mod out by reparametrizations...

article

Towards the next generation of simplified Dark Matter models

Andreas Albert, Martin Bauer, Jim Brooke, Oliver Buchmueller, more

Physics of the Dark Universe > 2017 > 16 > C > 49-70

This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete...

article

Simplified dark matter models with two Higgs doublets: I. Pseudoscalar mediators

Martin Bauer, Ulrich Haisch, Felix Kahlhoefer

Journal of High Energy Physics > 2017 > 2017 > 5 > 1-38

Abstract We study a new class of renormalisable simplified models for dark matter searches at the LHC that are based on two Higgs doublet models with an additional pseudoscalar mediator. In contrast to the spin-0 simplified models employed in analyses of Run I data these models are self-consistent, unitary and bounds from Higgs physics typically pose no constraints. Predictions for various missing...

article

Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Walid Habre, Nicola Disma, Katalin Virag, Karin Becke, more

The Lancet Respiratory Medicine > 2017 > 5 > 5 > 412-425

Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing...

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POSITRON EMISSION TOMOGRAPHY (6)
DIFFEOMORPHISM GROUP (5)
SHAPE SPACE (4)
(R)-[11C]VERAPAMIL (3)
ASA III (3)
CHRONIC PAIN (3)
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IOT (2)
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SHEEP (2)
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SOBOLEV METRICS OF FRACTIONAL ORDER (2)
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ACTUATORS (1)
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ALTER (1)
ALZHEIMER'S DISEASE (1)
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INFONA - science communication portal

Search results for: Martin Bauer

The effect of Tetrahydrocannabinol on optic nerve head blood flow in healthy subjects

Towards Improved Pharmacokinetic Models for the Analysis of Transporter-Mediated Hepatic Disposition of Drug Molecules with Positron Emission Tomography

Axion-like particles at future colliders

Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study

Comparing curves in homogeneous spaces

Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats

Universal properties of pseudoscalar mediators in dark matter extensions of 2HDMs

Hunting all the hidden photons

Landscape complexity promotes hoverflies across different types of semi‐natural habitats in farmland

Pharmacokinetics of the P-gp Inhibitor Tariquidar in Rats After Intravenous, Oral, and Intraperitoneal Administration

Longitudinal investigation of neuroinflammation and metabolite profiles in the APP_swe×PS1_Δe9 transgenic mouse model of Alzheimer's disease

Fractional Sobolev metrics on spaces of immersed curves

Collider probes of axion-like particles

Cytotoxic properties of lactate ester alkoxylates in relation to various EO/PO-alkoxylation degrees

Effect of P‐glycoprotein inhibition at the blood–brain barrier on brain distribution of (R)‐[¹¹C]verapamil in elderly vs. young subjects

On geodesic completeness for Riemannian metrics on smooth probability densities

The Square Root Velocity Framework for Curves in a Homogeneous Space

Towards the next generation of simplified Dark Matter models

Simplified dark matter models with two Higgs doublets: I. Pseudoscalar mediators

Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

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