Search results for: Anton Golovnin

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article

Interactions between BTB domain of CP190 and two adjacent regions in Su(Hw) are required for the insulator complex formation

Larisa Melnikova, Margarita Kostyuchenko, Varvara Molodina, Alexander Parshikov, more

Chromosoma > 2018 > 127 > 1 > 59-71

The best-studied Drosophila insulator complex consists of two BTB-containing proteins, the Mod(mdg4)-67.2 isoform and CP190, which are recruited cooperatively to chromatin through interactions with the DNA-binding architectural protein Su(Hw). While Mod(mdg4)-67.2 interacts only with Su(Hw), CP190 interacts with many other architectural proteins. In spite of the fact that CP190 is critical for the...

article

EAST affects the activity of Su(Hw) insulators by two different mechanisms in Drosophila melanogaster

Larisa Melnikova, Igor Shapovalov, Margarita Kostyuchenko, Pavel Georgiev, more

Chromosoma > 2017 > 126 > 2 > 299-311

Recent data suggest that insulators organize chromatin architecture in the nucleus. The best characterized Drosophila insulator, found in the gypsy retrotransposon, contains 12 binding sites for the Su(Hw) protein. Enhancer blocking, along with Su(Hw), requires BTB/POZ domain proteins, Mod(mdg4)-67.2 and CP190. Inactivation of Mod(mdg4)-67.2 leads to a direct repression of the yellow gene promoter...

article

Interaction between a pair of gypsy insulators or between heterologous gypsy and Wari insulators modulates Flp site-specific recombination in Drosophila melanogaster

Margarita Krivega, Ekaterina Savitskaya, Ivan Krivega, Marina Karakozova, more

Chromosoma > 2010 > 119 > 4 > 425-434

Chromatin insulators block the action of transcriptional enhancers when interposed between an enhancer and a promoter. An Flp technology was used to examine interactions between Drosophila gypsy and Wari insulators in somatic and germ cells. The gypsy insulator consists of 12 binding sites for the Su(Hw) protein, while the endogenous Wari insulator, located on the 3′ side of the white gene, is independent...

article

Evolutionarily Conserved E(y)2/Sus1 Protein Is Essential for the Barrier Activity of Su(Hw)-Dependent Insulators in Drosophila

Maria Kurshakova, Oksana Maksimenko, Anton Golovnin, Maria Pulina, more

Molecular Cell > 2007 > 27 > 2 > 332-338

Chromatin insulators affect interactions between promoters and enhancers/silencers and function as barriers for spreading of repressive chromatin. The Su(Hw) protein is responsible for activity of the best-studied Drosophila insulators. Here we demonstrate that an evolutionarily conserved protein, E(y)2/Sus1, is recruited to the Su(Hw) insulators via binding to the zinc-finger domain of Su(Hw). Partial...

article

P element-mediated duplications of genomic regions in Drosophila melanogaster

Anton Golovnin, Sofia Georgieva, Hayk Hovhannisyan, Karine Barseguyan, more

Chromosoma > 2002 > 111 > 2 > 126-138

Abstract. Previously we have described highly unstable yellow mutations induced by chimeric elements that consist of genomic sequences originating from different regions of the X chromosome flanked by identical copies of an internally deleted 1.2kb P element. To study further the origin and the mechanism of formation of chimeric mobile elements, we analyzed complex y-sc mutations, induced by inversions...

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Search results for: Anton Golovnin

Interactions between BTB domain of CP190 and two adjacent regions in Su(Hw) are required for the insulator complex formation

EAST affects the activity of Su(Hw) insulators by two different mechanisms in Drosophila melanogaster

Interaction between a pair of gypsy insulators or between heterologous gypsy and Wari insulators modulates Flp site-specific recombination in Drosophila melanogaster

Evolutionarily Conserved E(y)2/Sus1 Protein Is Essential for the Barrier Activity of Su(Hw)-Dependent Insulators in Drosophila

P element-mediated duplications of genomic regions in Drosophila melanogaster

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INFONA - science communication portal

Search results for: Anton Golovnin

Interactions between BTB domain of CP190 and two adjacent regions in Su(Hw) are required for the insulator complex formation

EAST affects the activity of Su(Hw) insulators by two different mechanisms in Drosophila melanogaster

Interaction between a pair of gypsy insulators or between heterologous gypsy and Wari insulators modulates Flp site-specific recombination in Drosophila melanogaster

Evolutionarily Conserved E(y)2/Sus1 Protein Is Essential for the Barrier Activity of Su(Hw)-Dependent Insulators in Drosophila

P element-mediated duplications of genomic regions in Drosophila melanogaster

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