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MyoD is a master regulator of myogenesis. Chromatin modifications required to trigger MyoD expression are still poorly described. Here, we demonstrate that the histone demethylase LSD1/KDM1a is recruited on the MyoD core enhancer upon muscle differentiation. Depletion of Lsd1 in myoblasts precludes the removal of H3K9 methylation and the recruitment of RNA polymerase II on the core enhancer, thereby...
Previous work has described the cell cycle phase-specific action of nerve growth factor (NGF). In the pheochromocytoma cell line PC12, NGF ellicits an anti-mitogenic effect, i.e. inhibition of the G1 to S transition, and provokes a differentiation response in the G1 phase, while a survival effect is stimulated elsewhere in the cell cycle. The proto-oncogene c-fos is also induced in the G1 phase...
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