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Missense substitutions and processivity errors in the translation of heterologous proteins are expected to occur at higher frequencies than the corresponding errors of normal translation. The resulting error-containing products may overload chaperone systems. Likewise, there may be a risk of an immunogenic response to heterologous proteins introduced into vertebrates. Recent work has been carried...
We studied the influence of an error-prone isoacceptor (tRNA Leu4 ), as well as an intermediate (tRNA Leu2 ) and a weak (tRNA Val ) competitor of tRNA Phe on the poly(Phe) synthesis rate. Even at very high excess concentrations of these noncognate ternary complexes there was no significant effect on the translation rate...
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