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Background
Rare coding mutations underlying deficiencies of antithrombin and proteins C and S contribute to familial venous thromboembolism (VTE). It is uncertain whether rare variants play a role in the etiology of VTE in the general population.
Objectives
We conducted a deep whole‐exome sequencing (WES) study to investigate the associations between rare coding variants and the risk of VTE in...
Protein C is an endogenous anticoagulant protein with anti‐inflammatory properties. Single‐nucleotide polymorphisms (SNPs) affect the levels of circulating protein C in European Americans. We performed a genome‐wide association (GWA) scan of plasma protein C concentration with approximately 2.5 million SNPs in 2,701 African Americans in the Atherosclerosis Risk in Communities Study. Seventy‐nine SNPs...
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