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Plasmids containing the origin of bidirectional replication (oriβ) of the Chinese hamster dihydrofolate reductase-encoding gene (DHFR) were tested for autonomous replication in vivo and in vitro. The results show that plasmids pX24 and pneoS13, that contain a 4.8- and a 11.5-kb fragment, respectively, spanning the oriβ region, are able to replicate autonomously in human cells and in a cell-free system...